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PMID: 22374090 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Role of phosphoinositides at the neuronal synapse.

Sub-cellular biochemistry ·Vol. 59 ·2012-00-00 ·Pages 131-75

Frere SG, Chang-Ileto B, Di Paolo G

Abstract

Synaptic transmission is amongst the most sophisticated and tightly controlled biological phenomena in higher eukaryotes. In the past few decades, tremendous progress has been made in our understanding of the molecular mechanisms underlying multiple facets of neurotransmission, both pre- and postsynaptically. Brought under the spotlight by pioneer studies in the areas of secretion and signal transduction, phosphoinositides and their metabolizing enzymes have been increasingly recognized as key protagonists in fundamental aspects of neurotransmission. Not surprisingly, dysregulation of phosphoinositide metabolism has also been implicated in synaptic malfunction associated with a variety of brain disorders. In the present chapter, we summarize current knowledge on the role of phosphoinositides at the neuronal synapse and highlight some of the outstanding questions in this research field.

MeSH Terms
Alzheimer Disease/metabolism,physiopathology Animals Biological Transport Calcium/metabolism Down Syndrome/metabolism,physiopathology Exocytosis Glutamic Acid/metabolism Humans Neurons/cytology,metabolism Phosphatidylinositols/chemistry,metabolism Receptors, AMPA/metabolism Receptors, N-Methyl-D-Aspartate/metabolism SNARE Proteins/metabolism Synapses/chemistry,metabolism Synaptic Transmission
Chemicals
Phosphatidylinositols Receptors, AMPA Receptors, N-Methyl-D-Aspartate SNARE Proteins Glutamic Acid Calcium
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Frere Samuel G
Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, 630 West 168th Street, P&S 12-420C, 10032, New York, USA.
Chang-Ileto Belle
Di Paolo Gilbert
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Article Info
Journal
Sub-cellular biochemistry
Abbr.
Subcell Biochem
ISSN
0306-0225
DOI
10.1007/978-94-007-3015-1_5
Published
2012-00-00
Pages
131-75
Language
English
Region
United States
NLM ID
0316571
PMCID
PMC3543677
Subset
IM
Grants
NIA NIH HHS · R03 AG033212 · United States
NICHD NIH HHS · R01 HD055457 · United States
NINDS NIH HHS · F31 NS058096 · United States
NICHD NIH HHS · R01 R01HD05547 · United States
NINDS NIH HHS · R01 NS056049 · United States
External Links
PubMed source DOI: 10.1007/978-94-007-3015-1_5 PMC Full Text
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