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PMID: 22505937 Published · ppublish English Journal Article

IQGAP Family Members in Yeast, Dictyostelium, and Mammalian Cells.

International journal of cell biology ·Vol. 2012 ·2012-00-00 ·Pages 894817

Shannon KB

Abstract

IQGAPs are a family of scaffolding proteins with multiple domains, named for the IQ motifs and GTPase activating protein (GAP) related domains. Despite their GAP homology, IQGAP proteins act as effectors for GTP-bound GTPases of the Ras superfamily and do not stimulate GTP hydrolysis. IQGAPs are found in eukaryotic cells from yeast to human, and localize to actin-containing structures such as lamellipodia, membrane ruffles, cell-cell adhesions, phagocytic cups, and the actomyosin ring formed during cytokinesis. Mammalian IQGAPs also act as scaffolds for signaling pathways. IQGAPs perform their myriad functions through association with a large number of proteins including filamentous actin (F-actin), GTPases, calcium-binding proteins, microtubule binding proteins, kinases, and receptors. The focus of this paper is on recent studies describing new binding partners, mechanisms of regulation, and biochemical and physiological functions of IQGAPs in yeast, amoeba, and mammalian cells.

Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Shannon Katie B
Department of Biological Sciences, Missouri University of Science and Technology, Rolla, MO 65409, USA.
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Article Info
Journal
International journal of cell biology
Abbr.
Int J Cell Biol
ISSN
1687-8884
DOI
10.1155/2012/894817
Published
2012-00-00
Epub
2012-00-21
Pages
894817
Language
English
Region
United States
NLM ID
101517861
PMCID
PMC3296274
External Links
PubMed source DOI: 10.1155/2012/894817 PMC Full Text
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