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PMID: 225541 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Cell surface expression of the env gene polyprotein of dual-tropic mink cell focus-forming murine leukemia virus.

Journal of virology ·Vol. 30 ·No. 3 ·1979-06-00 ·Pages 720-8

Famulari NG, Jelalian K

Abstract

Differences have been observed in the kinetics of processing of the env gene polyprotein of ecotropic, xenotropic, and dual-tropic mink cell focus-forming (MCF) murine leukemia virus. In pulse-chase experiments, the env gene polyprotein of the dural-tropic MCF virus exhibits a marked increase in stability relative to that of either ecotropic or xenotropic virus. A comparison of cell surface expression of env gene products of ecotropic, xenotropic, and dual-tropic MCF murine leukemia virus has been made. Only gp70 is accessible to lactoperoxidase-catalyzed radioiodination of fibroblasts infected by ecotropic or xenotropic virus, whereas both gp70 and the env gene polyprotein are expressed on the surface of dual-tropic MCF virus-infected cells.

MeSH Terms
Animals Cell Line Fibroblasts Genes, Viral Leukemia Virus, Murine/analysis,genetics,growth & development Mice Mink Peptides/analysis Viral Proteins/analysis,genetics Virus Replication
Chemicals
Peptides Viral Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Famulari N G
Jelalian K
References (31)
31 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.30.3.720-728.1979
Published
1979-06-00
Pages
720-8
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC353380
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.30.3.720-728.1979 PMC Full Text View journal details
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