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PMID: 23168566 Published · epublish English Journal Article

Estimation of genetic effects on BMI during adolescence in an ethnically diverse cohort: The National Longitudinal Study of Adolescent Health.

Nutrition & diabetes ·Vol. 2 ·2012-09-24 ·Pages e47

Graff M, North KE, Mohlke KL, Lange LA, Luo J, Harris KM, Young KL, Richardson AS, Lange EM, Gordon-Larsen P

Abstract

The contribution of genetic variants to body mass index (BMI) during adolescence across multiethnic samples is largely unknown. We selected genetic loci associated with BMI or obesity in European-descent samples and examined them in a multiethnic adolescent sample. In 5103 European American (EA), 1748 African American (AfA), 1304 Hispanic American (HA) and 439 Asian American (AsA) participants of the National Longitudinal Study of Adolescent Health (Add Health; ages 12-21 years, 47.5% male), we assessed the association between 41 established obesity-related single-nucleotide polymorphisms (SNPs) with BMI using additive genetic models, stratified by race/ethnicity, and in a pooled meta-analysis sample. We also compared the magnitude of effect for BMI-SNP associations in EA and AfA adolescents to comparable effect estimates from 11 861 EA and AfA adults in the Atherosclerosis Risk in Communities study (ages 45-64 years, 43.2% male). Thirty-five of 41 BMI-SNP associations were directionally consistent with published studies in European populations, 18 achieved nominal significance (P<0.05; effect sizes from 0.19 to 0.71 kg m(-2) increase in BMI per effect allele), while 4 (FTO, TMEM18, TFAP2B, MC4R) remained significant after Bonferroni correction (P<0.0015). Of 41 BMI-SNP associations in AfA, HA and AsA adolescents, nine, three and five, respectively, were directionally consistent and nominally significant. In the pooled meta-analysis, 36 of 41 effect estimates were directionally consistent and 21 of 36 were nominally significant. In EA adolescents, BMI effect estimates were larger (P<0.05) for variants near TMEM18, PTER and MC4R and smaller for variants near MTIF3 and NRXN3 compared with EA adults. Our findings suggest that obesity susceptibility loci may have a comparatively stronger role during adolescence than during adulthood, with variation across race/ethnic subpopulation.

Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Graff M
1] Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA [2] Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA.
North K E
Mohlke K L
Lange L A
Luo J
Harris K M
Young K L
Richardson A S
Lange E M
Gordon-Larsen P
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Article Info
Journal
Nutrition & diabetes
Abbr.
Nutr Diabetes
ISSN
2044-4052
DOI
10.1038/nutd.2012.20
Published
2012-09-24
Epub
2012-00-24
Pages
e47
Language
English
Region
England
NLM ID
101566341
PMCID
PMC3461356
Grants
NHLBI NIH HHS · HHSN268201100012C · United States
NHLBI NIH HHS · HHSN268201100009I · United States
NICHD NIH HHS · P01 HD031921 · United States
NHLBI NIH HHS · HHSN268201100010C · United States
NHLBI NIH HHS · R01 HL059367 · United States
NHLBI NIH HHS · HHSN268201100007C · United States
NHGRI NIH HHS · U01 HG004402 · United States
NHLBI NIH HHS · HHSN268201100006C · United States
NHLBI NIH HHS · HHSN268201100005I · United States
NCRR NIH HHS · UL1 RR025005 · United States
NHLBI NIH HHS · HHSN268201100008C · United States
NHLBI NIH HHS · HHSN268201100005G · United States
NHLBI NIH HHS · HHSN268201100008I · United States
NICHD NIH HHS · R01 HD073342 · United States
NHLBI NIH HHS · HHSN268201100011I · United States
NHLBI NIH HHS · HHSN268201100011C · United States
NHLBI NIH HHS · R01 HL086694 · United States
NCI NIH HHS · P30 CA016086 · United States
NHLBI NIH HHS · HHSN268201100009C · United States
NHLBI NIH HHS · HHSN268201100005C · United States
NHLBI NIH HHS · HHSN268201100007I · United States
NICHD NIH HHS · R01 HD057194 · United States
NICHD NIH HHS · R24 HD050924 · United States
NHLBI NIH HHS · R01 HL087641 · United States
External Links
PubMed source DOI: 10.1038/nutd.2012.20 PMC Full Text View journal details
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