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PMID: 23489878 Published · ppublish English Journal Article Research Support, N.I.H., Intramural Review

Inositol lipid regulation of lipid transfer in specialized membrane domains.

Trends in cell biology ·Vol. 23 ·No. 6 ·2013-06-00 ·Pages 270-8

Kim YJ, Hernandez ML, Balla T

Abstract

The highly dynamic membranous network of eukaryotic cells allows spatial organization of biochemical reactions to suit the complex metabolic needs of the cell. The unique lipid composition of organelle membranes in the face of dynamic membrane activities assumes that lipid gradients are constantly generated and maintained. Important advances have been made in identifying specialized membrane compartments and lipid transfer mechanisms that are critical for generating and maintaining lipid gradients. Remarkably, one class of minor phospholipids--the phosphoinositides--is emerging as important regulators of these processes. Here, we summarize several lines of research that have led to our current understanding of the connection between phosphoinositides and the transport of structural lipids and offer some thoughts on general principles possibly governing these processes.

MeSH Terms
Animals Biological Transport Carrier Proteins/chemistry,metabolism Cell Membrane/metabolism Humans Inositol/metabolism Membrane Lipids/metabolism Membrane Microdomains/metabolism Phosphatidylinositols/chemistry,metabolism
Chemicals
Carrier Proteins Membrane Lipids Phosphatidylinositols lipid transfer protein Inositol
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kim Yeun Ju
Section on Molecular Signal Transduction, Program for Developmental Neuroscience, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Hernandez Maria-Luisa Guzman
Balla Tamas
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Article Info
Journal
Trends in cell biology
Abbr.
Trends Cell Biol
ISSN
1879-3088
DOI
10.1016/j.tcb.2013.01.009
Published
2013-06-00
Epub
2013-00-13
Pages
270-8
Language
English
Region
England
NLM ID
9200566
PMCID
PMC3665726
Subset
IM
Grants
Intramural NIH HHS · Z99 HD999999 · United States
Intramural NIH HHS · ZIA HD000196-12 · United States
External Links
PubMed source DOI: 10.1016/j.tcb.2013.01.009 PMC Full Text View journal details
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