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PMID: 2447487 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Augmented mitogenic responsiveness to epidermal growth factor in murine fibroblasts that overexpress pp60c-src.

Molecular and cellular biology ·Vol. 8 ·No. 1 ·1988-01-00 ·Pages 497-501

Luttrell DK, Luttrell LM, Parsons SJ

Abstract

C3H10T1/2 murine fibroblasts overexpressing chicken pp60c-src showed a two- to fivefold enhanced incorporation of [3H]thymidine into DNA in response to epidermal growth factor (EGF) relative to that of the parent line. No difference in growth characteristics, number and affinity of EGF receptors, or hormone potency was attributable to c-src overexpression. These results suggest that pp60c-src may interact with the mitogenic signal transduction pathway of EGF in some event distal to hormone binding.

MeSH Terms
Animals Cell Cycle/drug effects Cell Line DNA/biosynthesis Dose-Response Relationship, Drug Epidermal Growth Factor/pharmacology ErbB Receptors/metabolism Mice Mitosis/drug effects Proto-Oncogene Proteins/physiology Proto-Oncogene Proteins pp60(c-src)
Chemicals
Proto-Oncogene Proteins Epidermal Growth Factor DNA ErbB Receptors Proto-Oncogene Proteins pp60(c-src)
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Luttrell D K
Department of Microbiology, School of Medicine, University of Virginia, Charlottesville 22908.
Luttrell L M
Parsons S J
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.8.1.497-501.1988
Published
1988-01-00
Pages
497-501
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC363160
Subset
IM
Grants
NCI NIH HHS · CA29243 · United States
NCI NIH HHS · CA39438 · United States
External Links
PubMed source DOI: 10.1128/mcb.8.1.497-501.1988 PMC Full Text View journal details
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