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PMID: 2569741 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A family of cyclin homologs that control the G1 phase in yeast.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 86 ·No. 16 ·1989-08-00 ·Pages 6255-9

Hadwiger JA, Wittenberg C, Richardson HE, de Barros Lopes M, Reed SI

Abstract

Two Saccharomyces cerevisiae genes were isolated based upon their dosage-dependent rescue of a temperature-sensitive mutation of the gene CDC28, which encodes a protein kinase involved in control of cell division. CLN1 and CLN2 encode closely related proteins that also share homology with cyclins. Cyclins, characterized by a dramatic periodicity of abundance through the cell cycle, are thought to be involved in mitotic induction in animal cells. A dominant mutation in the CLN2 gene, CLN2-1, advances the G1- to S-phase transition in cycling cells and impairs the ability of cells to arrest in G1 phase in response to external signals, suggesting that the encoded protein is involved in G1 control of the cell cycle in Saccharomyces.

MeSH Terms
Amino Acid Sequence Autoantigens/genetics DNA Transposable Elements DNA, Fungal/genetics,isolation & purification Genes Genes, Fungal Humans Interphase Molecular Sequence Data Multigene Family Mutation Nuclear Proteins/genetics Proliferating Cell Nuclear Antigen Protein Kinases/genetics Saccharomyces cerevisiae/cytology,genetics Sequence Homology, Nucleic Acid Tripeptidyl-Peptidase 1
Chemicals
Autoantigens DNA Transposable Elements DNA, Fungal Nuclear Proteins Proliferating Cell Nuclear Antigen Tripeptidyl-Peptidase 1 Protein Kinases TPP1 protein, human
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Hadwiger J A
Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, CA 92037.
Wittenberg C
Richardson H E
de Barros Lopes M
Reed S I
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.86.16.6255
Published
1989-08-00
Pages
6255-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC297816
Subset
IM
Grants
NIGMS NIH HHS · GM38328 · United States
External Links
PubMed source DOI: 10.1073/pnas.86.16.6255 PMC Full Text View journal details
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