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PMID: 2572559 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Inhibition of human lymphoproliferative responses by mycobacterial phenolic glycolipids.

Infection and immunity ·Vol. 57 ·No. 11 ·1989-11-00 ·Pages 3653-9

Fournie JJ, Adams E, Mullins RJ, Basten A

Abstract

The effect of mycobacterial phenolic glycolipids from Mycobacterium leprae, M. bovis BCG, and M. kansasii on in vitro proliferative responses by human blood mononuclear cells from healthy BCG vaccinees was investigated. All three phenolic glycolipids inhibited proliferation in a concentration-dependent manner. Inhibition was independent of the stimulus used and involved neither antigen-presenting cells nor antigen-specific CD8+ suppressor T cells. It was concluded that the phenomenon may be a general property of mycobacterial phenolic glycolipids, perhaps analogous to the growth-modulating properties of gangliosides. Despite the lack of specificity of inhibition in vitro, de facto specificity may occur in vivo by virtue of the localization of glycolipid in the leprosy lesions.

MeSH Terms
Antigen-Presenting Cells/immunology Antigens, Bacterial/immunology Antigens, Differentiation, T-Lymphocyte BCG Vaccine CD4-Positive T-Lymphocytes/immunology CD8 Antigens Glycolipids/immunology Humans In Vitro Techniques Lymphocyte Activation Mycobacterium/immunology Mycobacterium bovis/immunology Mycobacterium leprae/immunology Receptors, Interleukin-2/metabolism Structure-Activity Relationship T-Lymphocytes/immunology
Chemicals
Antigens, Bacterial Antigens, Differentiation, T-Lymphocyte BCG Vaccine CD8 Antigens Glycolipids Receptors, Interleukin-2
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Fournie J J
Clinical Immunology Research Centre, University of Sydney, Australia.
Adams E
Mullins R J
Basten A
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29 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.57.11.3653-3659.1989
Published
1989-11-00
Pages
3653-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC259880
Subset
IM
Corrections
ErratumIn
-
External Links
PubMed source DOI: 10.1128/iai.57.11.3653-3659.1989 PMC Full Text View journal details
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