Home LiteratureArticle Details
PMID: 3510979 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Strain variations in the murine cellular immune response to the phenolic glycolipid I antigen of Mycobacterium leprae.

Infection and immunity ·Vol. 51 ·No. 2 ·1986-02-00 ·Pages 495-500

Koster FT, Teuscher C, Matzner P, Umland E, Yanagihara D, Brennan PJ, Tung KS

Abstract

The cellular immune response to the Mycobacterium leprae-specific phenolic glycolipid I was examined in inbred mice immunized with M. leprae by in vivo delayed cutaneous hypersensitivity and in vitro lymphocyte proliferation. Whereas all mouse strains responded to M.leprae-induced delayed-type hypersensitivity and lymphocyte proliferation, only BALB.K was responsive in both assays to the glycolipid. Responsiveness was determined in part by non-H-2 genes, while the influence of H-2 genes was not apparent. Among congenic BALB/c mice differing only at Igh-C allotype loci, variations in responsiveness were found in both delayed-type hypersensitivity and lymphocytes proliferation assays, indicating a possible role for Igh-C loci-linked genes. Unresponsiveness in the lymphocyte proliferation assay to the glycolipid was inherited as a dominant trait in one set of responder X nonresponder F1 progeny. We conclude that after immunization with M. leprae organisms, the cell-mediated responses to the glycolipid, endowed with a single carbohydrate epitope, are under polygenic control, predominantly non-H-2-linked genes.

MeSH Terms
Animals Antigens, Bacterial/immunology Female Glycolipids/immunology Hypersensitivity, Delayed Immunity, Cellular Leprosy/immunology Lymphocyte Activation Mice Mice, Inbred Strains Mycobacterium leprae/immunology Species Specificity
Chemicals
Antigens, Bacterial Glycolipids phenolic glycolipid I, Mycobacterium leprae
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Koster F T
Teuscher C
Matzner P
Umland E
Yanagihara D
Brennan P J
Tung K S
References (28)
28 references, click to expand
  1. Inbred mouse strain resistance to Mycobacterium lepraemurium follows the Ity/Lsh pattern.
    Immunology. 1982 Sep;47(1):149-56 PMID: 6749659
  2. Genetics of the antibody response to dextran in mice.
    Science. 1972 Jul 14;177(4044):178-80 PMID: 4114394
  3. Structure and antigenicity of the major specific glycolipid antigen of Mycobacterium leprae.
    J Biol Chem. 1982 Dec 25;257(24):15072-8 PMID: 6184369
  4. Functional differentiation in the genetic control of murine T lymphocyte responses to human fibrinopeptide B.
    J Immunol. 1983 Feb;130(2):637-43 PMID: 6217245
  5. HLA and susceptibility to leprosy.
    Immunol Rev. 1983;70:89-112 PMID: 6339369
  6. Role of the major histocompatibility complex in resistance and granuloma formation in response to Mycobacterium lepraemurium infection.
    Infect Immun. 1983 May;40(2):720-5 PMID: 6220974
  7. Serological activity of a characteristic phenolic glycolipid from Mycobacterium leprae in sera from patients with leprosy and tuberculosis.
    Clin Exp Immunol. 1983 May;52(2):271-9 PMID: 6407793
  8. Serological specificity of phenolic glycolipid I from Mycobacterium leprae and use in serodiagnosis of leprosy.
    Infect Immun. 1983 Sep;41(3):1077-83 PMID: 6193065
  9. Generation and characterization of monoclonal antibodies to the phenolic glycolipid of Mycobacterium leprae.
    Infect Immun. 1984 Jan;43(1):183-8 PMID: 6360894
  10. T cell proliferation in Mycobacterium lepraemurium infection. I. Lack of correlation between antigen-specific proliferation of Lyt 1 + 23- cells and resistance in lethal infections.
    Immunology. 1984 Jan;51(1):185-92 PMID: 6197359
  11. T cell alloantigens encoded by the IgT-C region of chromosome 12 in the mouse.
    Adv Immunol. 1983;34:1-38 PMID: 6416036
  12. Chemical synthesis and serology of disaccharides and trisaccharides of phenolic glycolipid antigens from the leprosy bacillus and preparation of a disaccharide protein conjugate for serodiagnosis of leprosy.
    Infect Immun. 1984 Jan;43(1):245-52 PMID: 6360898
  13. The nature of the electron-transparent zone that surrounds Mycobacterium lepraemurium inside host cells.
    J Gen Microbiol. 1973 Jul;77(1):79-87 PMID: 4579442
  14. Genetic control of the immune response: the effect of non-H-2 linked genes on antibody production.
    J Immunol. 1974 Apr;112(4):1329-36 PMID: 4360861
  15. T lymphocyte-enriched murine peritoneal exudate cells. I. A reliable assay for antigen-induced T lymphocyte proliferation.
    J Immunol. 1975 Nov;115(5):1330-8 PMID: 51890
  16. Radiation from tritiated thymidine perturbs the cell cycle progression of stimulated lymphocytes.
    Science. 1979 Mar 9;203(4384):1025-7 PMID: 424727
  17. Influence of route of Mycobacterium lepraemurium injection on susceptibility to mouse leprosy and on lymphoblastic transformation.
    Infect Immun. 1980 Jun;28(3):660-8 PMID: 6995320
  18. A novel phenolic glycolipid from Mycobacterium leprae possibly involved in immunogenicity and pathogenicity.
    J Bacteriol. 1981 Sep;147(3):728-35 PMID: 7024248
  19. Cellular immunity to Bacteroides fragilis capsular polysaccharide.
    J Exp Med. 1982 Apr 1;155(4):1188-97 PMID: 6174672
  20. Lymphocyte suppression in leprosy induced by unique M. leprae glycolipid.
    Nature. 1984 Mar 8-14;308(5955):194-6 PMID: 6366573
  21. H-2-linked genes which modify resistance of C57BL/10 mice to subcutaneous infection with Mycobacterium lepraemurium.
    Infect Immun. 1984 Dec;46(3):635-8 PMID: 6389355
  22. Phenolic glycolipid 1 of Mycobacterium leprae causes nonspecific inflammation but has no effect on cell-mediated responses in mice.
    Infect Immun. 1984 Dec;46(3):802-8 PMID: 6389362
  23. HLA-linked control of predisposition to lepromatous leprosy.
    J Infect Dis. 1985 Jan;151(1):9-14 PMID: 3880800
  24. Antibody response to phenolic glycolipid I in inbred mice immunized with Mycobacterium leprae.
    Infect Immun. 1985 May;48(2):474-9 PMID: 3921463
  25. Regulation of IgG memory responses by helper and suppressor T cells activated by the type 2 antigen, polyvinylpyrrolidone.
    J Exp Med. 1985 Jun 1;161(6):1357-67 PMID: 3159816
  26. Strain differences in the antibody plaque-forming cell responses of inbred mice to pneumococcal polysaccharide.
    Cell Immunol. 1971 Feb;2(1):73-81 PMID: 4399154
  27. Characterization of the cellular immune defect in lepromatous leprosy: a specific lack of circulating Mycobacterium leprae-reactive lymphocytes.
    Clin Exp Immunol. 1971 Dec;9(6):821-31 PMID: 4945738
  28. H-2 linkage control of resistance to subcutaneous infection with Mycobacterium lepraemurium.
    Infect Immun. 1982 Nov;38(2):434-9 PMID: 6815095
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.51.2.495-500.1986
Published
1986-02-00
Pages
495-500
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC262362
Subset
IM
Grants
NIAID NIH HHS · AI 21057 · United States
NIADDK NIH HHS · AM 33004 · United States
External Links
PubMed source DOI: 10.1128/iai.51.2.495-500.1986 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2