Home LiteratureArticle Details
PMID: 26426971 Published · epublish English Journal Article Meta-Analysis

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.

PLoS genetics ·Vol. 11 ·No. 10 ·2015-10-00 ·Pages e1005378

Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, Czajkowski J, Esko T, Fall T, Kilpeläinen TO, Lu Y, Mägi R, Mihailov E, Pers TH, Rüeger S, Teumer A, Ehret GB, Ferreira T, Heard-Costa NL, Karjalainen J, Lagou V, Mahajan A, Neinast MD, Prokopenko I, Simino J, Teslovich TM, Jansen R, Westra HJ, White CC, Absher D, Ahluwalia TS, Ahmad S, Albrecht E, Alves AC, Bragg-Gresham JL, de Craen AJ, Bis JC, Bonnefond A, Boucher G, Cadby G, Cheng YC, Chiang CW, Delgado G, Demirkan A, Dueker N, Eklund N, Eiriksdottir G, Eriksson J, Feenstra B, Fischer K, Frau F, Galesloot TE, Geller F, Goel A, Gorski M, Grammer TB, Gustafsson S, Haitjema S, Hottenga JJ, Huffman JE, Jackson AU, Jacobs KB, Johansson Å, Kaakinen M, Kleber ME, Lahti J, Mateo Leach I, Lehne B, Liu Y, Lo KS, Lorentzon M, Luan J, Madden PA, Mangino M, McKnight B, Medina-Gomez C, Monda KL, Montasser ME, Müller G, Müller-Nurasyid M, Nolte IM, Panoutsopoulou K, Pascoe L, Paternoster L, Rayner NW, Renström F, Rizzi F, Rose LM, Ryan KA, Salo P, Sanna S, Scharnagl H, Shi J, Smith AV, Southam L, Stančáková A, Steinthorsdottir V, Strawbridge RJ, Sung YJ, Tachmazidou I, Tanaka T, Thorleifsson G, Trompet S, Pervjakova N, Tyrer JP, Vandenput L, van der Laan SW, van der Velde N, van Setten J, van Vliet-Ostaptchouk JV, Verweij N, Vlachopoulou E, Waite LL, Wang SR, Wang Z, Wild SH, Willenborg C, Wilson JF, Wong A, Yang J, Yengo L, Yerges-Armstrong LM, Yu L, Zhang W, Zhao JH, Andersson EA, Bakker SJ, Baldassarre D, Banasik K, Barcella M, Barlassina C, Bellis C, Benaglio P, Blangero J, Blüher M, Bonnet F, Bonnycastle LL, Boyd HA, Bruinenberg M, Buchman AS, Campbell H, Chen YD, Chines PS, Claudi-Boehm S, Cole J, Collins FS, de Geus EJ, de Groot LC, Dimitriou M, Duan J, Enroth S, Eury E, Farmaki AE, Forouhi NG, Friedrich N, Gejman PV, Gigante B, Glorioso N, Go AS, Gottesman O, Gräßler J, Grallert H, Grarup N, Gu YM, Broer L, Ham AC, Hansen T, Harris TB, Hartman CA, Hassinen M, Hastie N, Hattersley AT, Heath AC, Henders AK, Hernandez D, Hillege H, Holmen O, Hovingh KG, Hui J, Husemoen LL, Hutri-Kähönen N, Hysi PG, Illig T, De Jager PL, Jalilzadeh S, Jørgensen T, Jukema JW, Juonala M, Kanoni S, Karaleftheri M, Khaw KT, Kinnunen L, Kittner SJ, Koenig W, Kolcic I, Kovacs P, Krarup NT, Kratzer W, Krüger J, Kuh D, Kumari M, Kyriakou T, Langenberg C, Lannfelt L, Lanzani C, Lotay V, Launer LJ, Leander K, Lindström J, Linneberg A, Liu YP, Lobbens S, Luben R, Lyssenko V, Männistö S, Magnusson PK, McArdle WL, Menni C, Merger S, Milani L, Montgomery GW, Morris AP, Narisu N, Nelis M, Ong KK, Palotie A, Pérusse L, Pichler I, Pilia MG, Pouta A, Rheinberger M, Ribel-Madsen R, Richards M, Rice KM, Rice TK, Rivolta C, Salomaa V, Sanders AR, Sarzynski MA, Scholtens S, Scott RA, Scott WR, Sebert S, Sengupta S, Sennblad B, Seufferlein T, Silveira A, Slagboom PE, Smit JH, Sparsø TH, Stirrups K, Stolk RP, Stringham HM, Swertz MA, Swift AJ, Syvänen AC, Tan ST, Thorand B, Tönjes A, Tremblay A, Tsafantakis E, van der Most PJ, Völker U, Vohl MC, Vonk JM, Waldenberger M, Walker RW, Wennauer R, Widén E, Willemsen G, Wilsgaard T, Wright AF, Zillikens MC, van Dijk SC, van Schoor NM, Asselbergs FW, de Bakker PI, Beckmann JS, Beilby J, Bennett DA, Bergman RN, Bergmann S, Böger CA, Boehm BO, Boerwinkle E, Boomsma DI, Bornstein SR, Bottinger EP, Bouchard C, Chambers JC, Chanock SJ, Chasman DI, Cucca F, Cusi D, Dedoussis G, Erdmann J, Eriksson JG, Evans DA, de Faire U, Farrall M, Ferrucci L, Ford I, Franke L, Franks PW, Froguel P, Gansevoort RT, Gieger C, Grönberg H, Gudnason V, Gyllensten U, Hall P, Hamsten A, van der Harst P, Hayward C, Heliövaara M, Hengstenberg C, Hicks AA, Hingorani A, Hofman A, Hu F, Huikuri HV, Hveem K, James AL, Jordan JM, Jula A, Kähönen M, Kajantie E, Kathiresan S, Kiemeney LA, Kivimaki M, Knekt PB, Koistinen HA, Kooner JS, Koskinen S, Kuusisto J, Maerz W, Martin NG, Laakso M, Lakka TA, Lehtimäki T, Lettre G, Levinson DF, Lind L, Lokki ML, Mäntyselkä P, Melbye M, Metspalu A, Mitchell BD, Moll FL, Murray JC, Musk AW, Nieminen MS, Njølstad I, Ohlsson C, Oldehinkel AJ, Oostra BA, Palmer LJ, Pankow JS, Pasterkamp G, Pedersen NL, Pedersen O, Penninx BW, Perola M, Peters A, Polašek O, Pramstaller PP, Psaty BM, Qi L, Quertermous T, Raitakari OT, Rankinen T, Rauramaa R, Ridker PM, Rioux JD, Rivadeneira F, Rotter JI, Rudan I, den Ruijter HM, Saltevo J, Sattar N, Schunkert H, Schwarz PE, Shuldiner AR, Sinisalo J, Snieder H, Sørensen TI, Spector TD, Staessen JA, Stefania B, Thorsteinsdottir U, Stumvoll M, Tardif JC, Tremoli E, Tuomilehto J, Uitterlinden AG, Uusitupa M, Verbeek AL, Vermeulen SH, Viikari JS, Vitart V, Völzke H, Vollenweider P, Waeber G, Walker M, Wallaschofski H, Wareham NJ, Watkins H, Zeggini E, CHARGE Consortium, DIAGRAM Consortium, GLGC Consortium, Global-BPGen Consortium, ICBP Consortium, MAGIC Consortium, Chakravarti A, Clegg DJ, Cupples LA, Gordon-Larsen P, Jaquish CE, Rao DC, Abecasis GR, Assimes TL, Barroso I, Berndt SI, Boehnke M, Deloukas P, Fox CS, Groop LC, Hunter DJ, Ingelsson E, Kaplan RC, McCarthy MI, Mohlke KL, O'Connell JR, Schlessinger D, Strachan DP, Stefansson K, van Duijn CM, Hirschhorn JN, Lindgren CM, Heid IM, North KE, Borecki IB, Kutalik Z, Loos RJ

Abstract

Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men >50y, women ≤50y, women >50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (≥50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape.

MeSH Terms
Adult Age Factors Aged Body Mass Index Body Size/genetics Chromosome Mapping Female Genetic Predisposition to Disease Genome-Wide Association Study Humans Male Middle Aged Polymorphism, Single Nucleotide Sex Characteristics Waist-Hip Ratio Whites
Authors & Affiliations
445 authors, click to expand affiliations / ORCID
Winkler Thomas W
Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University Regensburg, Regensburg, Germany.
Justice Anne E
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Graff Mariaelisa
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Barata Llilda
Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Feitosa Mary F
Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Chu Su
Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
Czajkowski Jacek
Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Esko Tõnu
Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States of America; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, United States of America; Estonian Genome Center, Univeristy of Tartu, Tartu, Estonia; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America.
Fall Tove
Science for Life Laboratory, Uppsala University, Uppsala, Sweden; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.
Kilpeläinen Tuomas O
Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Lu Yingchang
The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Mägi Reedik
Estonian Genome Center, Univeristy of Tartu, Tartu, Estonia; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Mihailov Evelin
Estonian Genome Center, Univeristy of Tartu, Tartu, Estonia.
Pers Tune H
Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, United States of America; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America; Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.
Rüeger Sina
Swiss Institute of Bioinformatics, Lausanne, Switzerland; Institute of Social and Preventive Medicine, University Hospital Lausanne (CHUV), Lausanne, Switzerland.
Teumer Alexander
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Ehret Georg B
Department of Specialties of Internal Medicine, Geneva University Hospital, Geneva, Switzerland; Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Ferreira Teresa
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Heard-Costa Nancy L
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America; National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts, United States of America.
Karjalainen Juha
University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.
Lagou Vasiliki
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom.
Mahajan Anubha
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Neinast Michael D
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.
Prokopenko Inga
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom; Hammersmith Hospital, London, United Kingdom; Department of Genomics of Common Diseases, School of Public Health, Imperial College London, London, United Kingdom.
Simino Jeannette
Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Teslovich Tanya M
Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
Jansen Rick
Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands.
Westra Harm-Jan
Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America; Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America; Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, United States of America.
White Charles C
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
Absher Devin
HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, United States of America.
Ahluwalia Tarunveer S
Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Steno Diabetes Center A/S, Gentofte, Denmark; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Ahmad Shafqat
Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden.
Albrecht Eva
Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Alves Alexessander Couto
Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, United Kingdom.
Bragg-Gresham Jennifer L
Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
de Craen Anton J M
Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Bis Joshua C
Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America; Department of Medicine, University of Washington, Seattle, Washington, United States of America.
Bonnefond Amélie
CNRS UMR 8199, Lille, France; European Genomic Institute for Diabetes, Lille, France; Université de Lille 2, Lille, France.
Boucher Gabrielle
Montreal Heart Institute, Montréal, Québec, Canada.
Cadby Gemma
Centre for Genetic Origins of Health and Disease, University of Western Australia, Crawley, Western Australia, Australia.
Cheng Yu-Ching
VA Maryland Health Care System, Baltimore, Maryland, United States of America; University of Maryland School of Medicine, Department of Medicine, Baltimore, Maryland, United States of America.
Chiang Charleston W K
Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, California, United States of America.
Delgado Graciela
Vth Department of Medicine, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany.
Demirkan Ayse
Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Dueker Nicole
Universiy of Maryland School of Medicine, Department of Epidemiology & Public Health, Baltimore, Maryland, United States of America.
Eklund Niina
National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland; National Institute for Health and Welfare, Public Health Genomics Unit, Helsinki, Finland; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Eiriksdottir Gudny
Icelandic Heart Association, Kopavogur, Iceland.
Eriksson Joel
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Feenstra Bjarke
Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Fischer Krista
Estonian Genome Center, Univeristy of Tartu, Tartu, Estonia.
Frau Francesca
Department of Health Sciences, University of Milan, Milan, Italy; Filarete Foundation, Genomic and Bioinformatics Unit, Milano, Italy.
Galesloot Tessel E
Radboud university medical center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, The Netherlands.
Geller Frank
Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Goel Anuj
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Gorski Mathias
Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University Regensburg, Regensburg, Germany; Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Grammer Tanja B
Vth Department of Medicine, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany.
Gustafsson Stefan
Science for Life Laboratory, Uppsala University, Uppsala, Sweden; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.
Haitjema Saskia
Experimental Cardiology and laboratory of clinical chemistry, UMCU, Utrecht, The Netherlands.
Hottenga Jouke-Jan
Department of Biological Psychology, VU University, Amsterdam, The Netherlands.
Huffman Jennifer E
National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts, United States of America; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland.
Jackson Anne U
Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
Jacobs Kevin B
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America; Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, United States of America.
Johansson Åsa
Science for Life Laboratory, Uppsala University, Uppsala, Sweden; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Kaakinen Marika
Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London, United Kingdom; Institute of Health Sciences, University of Oulu, Oulu, Finland.
Kleber Marcus E
Vth Department of Medicine, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany.
Lahti Jari
Folkhälsan Research Centre, Helsinki, Finland; Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.
Mateo Leach Irene
University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, Netherlands.
Lehne Benjamin
Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom.
Liu Youfang
Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chaper Hill, North Carolina, United States of America.
Lo Ken Sin
Montreal Heart Institute, Montréal, Québec, Canada.
Lorentzon Mattias
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Luan Jian'an
MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Madden Pamela A F
Washington University Medical School, St. Louis, Missouri, United States of America.
Mangino Massimo
Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.
McKnight Barbara
Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America; Program in Biostatistics and Biomathematics, Divison of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America; Department of Biostatistics, University of Washington, Seattle, Washington, United States of America.
Medina-Gomez Carolina
Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Monda Keri L
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America; The Center for Observational Research, Amgen Inc., Thousand Oaks, California, United States of America.
Montasser May E
Program for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes & Nutrition, Dept of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
Müller Gabriele
Center for Evidence Based Healthcare, University of Dresden, Medical Faculty Carl Gustav Carus, Dresden, Germany.
Müller-Nurasyid Martina
Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany; DZHK (German Centre for Cardiovascular Research), partnersite Munich Heart Alliance, Munich, Germany.
Nolte Ilja M
University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.
Panoutsopoulou Kalliope
Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom.
Pascoe Laura
Institute of Cell & Molecular Biosciences, Newcastle University, Newcastle, United Kingdom.
Paternoster Lavinia
MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
Rayner Nigel W
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom; Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom.
Renström Frida
Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden.
Rizzi Federica
Department of Health Sciences, University of Milan, Milan, Italy; Filarete Foundation, Genomic and Bioinformatics Unit, Milano, Italy.
Rose Lynda M
Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America.
Ryan Kathy A
Program for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes & Nutrition, Dept of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
Salo Perttu
National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland; National Institute for Health and Welfare, Public Health Genomics Unit, Helsinki, Finland.
Sanna Serena
Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato, Italy.
Scharnagl Hubert
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
Shi Jianxin
National Cancer Institute, Bethesda, Maryland, United States of America.
Smith Albert Vernon
Icelandic Heart Association, Kopavogur, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Southam Lorraine
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom.
Stančáková Alena
Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Steinthorsdottir Valgerdur
deCODE Genetics, Amgen inc., Reykjavik, Iceland.
Strawbridge Rona J
Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Sung Yun Ju
Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Tachmazidou Ioanna
Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom.
Tanaka Toshiko
Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, United States of America.
Thorleifsson Gudmar
deCODE Genetics, Amgen inc., Reykjavik, Iceland.
Trompet Stella
Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Pervjakova Natalia
Estonian Genome Center, Univeristy of Tartu, Tartu, Estonia; National Institute for Health and Welfare, Public Health Genomics Unit, Helsinki, Finland; Institute of Cell and Molecular Biology, Department of Biotechnology, University of Tartu, Tartu, Estonia; University of Helsinki, Helsinki, Finland.
Tyrer Jonathan P
Department of Oncology, University of Cambridge, Cambridge, United Kingdom.
Vandenput Liesbeth
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
van der Laan Sander W
Experimental Cardiology and laboratory of clinical chemistry, UMCU, Utrecht, The Netherlands.
van der Velde Nathalie
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Internal Medicine, Section of Geriatric Medicine, Academic Medical Center, Amsterdam, The Netherlands.
van Setten Jessica
Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands.
van Vliet-Ostaptchouk Jana V
University of Groningen, University Medical Center Groningen, Department of Endocrinology, Groningen, The Netherlands.
Verweij Niek
University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, Netherlands.
Vlachopoulou Efthymia
Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland.
Waite Lindsay L
HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, United States of America.
Wang Sophie R
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America; Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America; Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts, United States of America; Divisions of Genetics and Endocrinology and Program in Genomics, Boston's Children's Hospital, Boston, Massachusetts, United States of America.
Wang Zhaoming
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America; Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, United States of America.
Wild Sarah H
Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland.
Willenborg Christina
DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Lübeck, Germany; Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Lübeck, Germany.
Wilson James F
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland.
Wong Andrew
MRC Unit for Lifelong Health & Ageing at UCL, London, United Kingdom.
Yang Jian
Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
Yengo Loïc
CNRS UMR 8199, Lille, France; European Genomic Institute for Diabetes, Lille, France; Université de Lille 2, Lille, France.
Yerges-Armstrong Laura M
Program for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes & Nutrition, Dept of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
Yu Lei
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America.
Zhang Weihua
Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom; Ealing Hospital NHS Trust, Middlesex, United Kingdom.
Zhao Jing Hua
MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Andersson Ehm A
Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Bakker Stephan J L
University of Groningen, University Medical Center Groningen, Department of Medicine, Groningen, Netherlands.
Baldassarre Damiano
Centro Cardiologico Monzino, IRCCS, Milan, Italy; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy.
Banasik Karina
Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Barcella Matteo
Department of Health Sciences, University of Milan, Milan, Italy.
Barlassina Cristina
Department of Health Sciences, University of Milan, Milan, Italy.
Bellis Claire
Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, United States of America; Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
Benaglio Paola
Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America; Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.
Blangero John
Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, United States of America.
Blüher Matthias
University of Leipzig, IFB Adiposity Diseases, Leipzig, Germany; University of Leipzig, Department of Medicine, Leipzig, Germany.
Bonnet Fabrice
University Rennes 1, Rennes, France.
Bonnycastle Lori L
Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America.
Boyd Heather A
Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Bruinenberg Marcel
University of Groningen, University Medical Center Groningen, The LifeLines Cohort Study, Groningen, The Netherlands.
Buchman Aron S
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America.
Campbell Harry
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland.
Chen Yii-Der Ida
Los Angeles BioMedical Resesarch Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America.
Chines Peter S
Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America.
Claudi-Boehm Simone
Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany.
Cole John
VA Maryland Health Care System, Baltimore, Maryland, United States of America; Universiy of Maryland School of Medicine, Department of Neurology, Baltimore, Maryland, United States of America.
Collins Francis S
Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America.
de Geus Eco J C
Department of Biological Psychology, VU University, Amsterdam, The Netherlands; EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands.
de Groot Lisette C P G M
Department of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
Dimitriou Maria
Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom; Department of Dietetics-Nutrition, Harokopio University, Athens, Greece.
Duan Jubao
NorthShore University HealthSystem, Evanston, Illinois, United States of America; University of Chicago, Chicago, Illinois, United States of America.
Enroth Stefan
Science for Life Laboratory, Uppsala University, Uppsala, Sweden; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Eury Elodie
CNRS UMR 8199, Lille, France; European Genomic Institute for Diabetes, Lille, France; Université de Lille 2, Lille, France.
Farmaki Aliki-Eleni
Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Forouhi Nita G
MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Friedrich Nele
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
Gejman Pablo V
NorthShore University HealthSystem, Evanston, Illinois, United States of America; University of Chicago, Chicago, Illinois, United States of America.
Gigante Bruna
Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Glorioso Nicola
Hypertension and Related Disease Centre, AOU-University of Sassari, Sassari, Italy.
Go Alan S
Kaiser Permanente, Division of Research, Oakland, California, United States of America.
Gottesman Omri
The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Department of Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Gräßler Jürgen
Department of Medicine III, Pathobiochemistry, University of Dresden, Dresden, Germany.
Grallert Harald
Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany.
Grarup Niels
Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Gu Yu-Mei
Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium.
Broer Linda
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Ham Annelies C
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Hansen Torben
Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
Harris Tamara B
Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland, United States of America; National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America.
Hartman Catharina A
University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, The Netherlands.
Hassinen Maija
Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Hastie Nicholas
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland.
Hattersley Andrew T
Institue of Biomedical & Clinical Science, University of Exeter, Exeter, United Kingdom.
Heath Andrew C
Washington University Medical School, St. Louis, Missouri, United States of America.
Henders Anjali K
QIMR Bergofer Medical Research Institute, Brisbane, Queensland, Australia.
Hernandez Dena
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America.
Hillege Hans
University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, Netherlands.
Holmen Oddgeir
Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway.
Hovingh Kees G
Department Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.
Hui Jennie
Pathwest Laboratory Medicine of Western Australia, Nedlands, Western Australia,Australia; School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Western Australia, Australia; School of Population Health, University of Western Australia, Nedlands, Western Australia, Australia.
Husemoen Lise L
Research Centre for Prevention and Health, Glostrup Hospital, Glostrup, Denmark.
Hutri-Kähönen Nina
Department of Pediatrics, University of Tampere School of Medicine, Tampere, Finland; Department of Pediatrics,Tampere University Hospital, Tampere, Finland.
Hysi Pirro G
Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.
Illig Thomas
Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Hannover Unified Biobank, Hannover Medical School, Hannover, Germany; Institute of Human Genetics, Hannover Medical School, Hanover, Germany.
De Jager Philip L
Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America; Harvard Medical School, Boston, Massachusetts,United States of America; Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts,United States of America.
Jalilzadeh Shapour
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Jørgensen Torben
Research Centre for Prevention and Health, Glostrup Hospital, Glostrup, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Faculty of Medicine, University of Aalborg, Aalborg, Denmark.
Jukema J Wouter
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands; Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands.
Juonala Markus
Division of Medicine, Turku University Hospital, Turku, Finland; Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Medicine, University of Turku, Turku, Finland.
Kanoni Stavroula
Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Karaleftheri Maria
Echinos Medical Centre, Echinos, Greece.
Khaw Kay Tee
Clinical Gerontology Unit, Addenbrooke's Hospital, Cambridge, United Kingdom.
Kinnunen Leena
Department of Health, National Institute for Health and Welfare, Helsinki, Finland.
Kittner Steven J
VA Maryland Health Care System, Baltimore, Maryland, United States of America; Universiy of Maryland School of Medicine, Department of Neurology, Baltimore, Maryland, United States of America.
Koenig Wolfgang
Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm, Germany.
Kolcic Ivana
Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia.
Kovacs Peter
University of Leipzig, IFB Adiposity Diseases, Leipzig, Germany.
Krarup Nikolaj T
Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Kratzer Wolfgang
Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany.
Krüger Janine
Department of Medicine A, University Medicine Greifswald, Greifswald, Germany.
Kuh Diana
MRC Unit for Lifelong Health & Ageing at UCL, London, United Kingdom.
Kumari Meena
Department of Epidemiology and Public Health, UCL, London, United Kingdom.
Kyriakou Theodosios
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Langenberg Claudia
MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom; Department of Epidemiology and Public Health, UCL, London, United Kingdom.
Lannfelt Lars
Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden.
Lanzani Chiara
Chair of Nephrology, Università Vita Salute San Raffaele, Segrate (Milan), Italy; Genomics of Renal Disease and Hypertension Unit, IRCCS San Raffaele Scientific Institute, Segrate (Milan), Italy.
Lotay Vaneet
Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada.
Launer Lenore J
National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America.
Leander Karin
Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Lindström Jaana
Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.
Linneberg Allan
Research Centre for Prevention and Health, Glostrup Hospital, Glostrup, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Experimental Research, Rigshospitalet, Glostrup, Denmark.
Liu Yan-Ping
Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium.
Lobbens Stéphane
CNRS UMR 8199, Lille, France; European Genomic Institute for Diabetes, Lille, France; Université de Lille 2, Lille, France.
Luben Robert
Strangeways Research Laboratory Wort's Causeway, Cambridge, United Kingdom.
Lyssenko Valeriya
Steno Diabetes Center A/S, Gentofte, Denmark; Lund University Diabetes Centre and Department of Clinical Science, Diabetes & Endocrinology Unit, Lund University, Malmö, Sweden.
Männistö Satu
National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland.
Magnusson Patrik K
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
McArdle Wendy L
School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
Menni Cristina
Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.
Merger Sigrun
Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany.
Milani Lili
Estonian Genome Center, Univeristy of Tartu, Tartu, Estonia.
Montgomery Grant W
QIMR Bergofer Medical Research Institute, Brisbane, Queensland, Australia.
Morris Andrew P
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom.
Narisu Narisu
Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America.
Nelis Mari
Estonian Genome Center, Univeristy of Tartu, Tartu, Estonia.
Ong Ken K
MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom; MRC Unit for Lifelong Health & Ageing at UCL, London, United Kingdom; Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom.
Palotie Aarno
Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland; Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom; Massachusetts General Hospital, Center for Human Genetic Research, Psychiatric and Neurodevelopmental Genetics Unit, Boston, Massachusetts, United States of America.
Pérusse Louis
Department of Kinesiology, Laval University, Québec City, Québec, Canada; Institute of Nutrition and Functional Foods, Laval University, Québec City, Québec, Canada.
Pichler Irene
Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Affiliated Institute of the University of Lübeck, Lübeck, Germany.
Pilia Maria G
Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato, Italy.
Pouta Anneli
Department of Children, Young People and Families, National Institute for Health and Welfare, Helsinki, Finland; Department of Obstetrics and Gynecology, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
Rheinberger Myriam
Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Ribel-Madsen Rasmus
Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Richards Marcus
MRC Unit for Lifelong Health & Ageing at UCL, London, United Kingdom.
Rice Kenneth M
Department of Biostatistics, University of Washington, Seattle, Washington, United States of America.
Rice Treva K
Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Rivolta Carlo
Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.
Salomaa Veikko
National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland.
Sanders Alan R
NorthShore University HealthSystem, Evanston, Illinois, United States of America; University of Chicago, Chicago, Illinois, United States of America.
Sarzynski Mark A
Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.
Scholtens Salome
University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.
Scott Robert A
MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Scott William R
Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom; Ealing Hospital NHS Trust, Middlesex, United Kingdom.
Sebert Sylvain
Institute of Health Sciences, University of Oulu, Oulu, Finland.
Sengupta Sebanti
Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
Sennblad Bengt
Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden; Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.
Seufferlein Thomas
Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany.
Silveira Angela
Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Slagboom P Eline
Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Smit Jan H
Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands.
Sparsø Thomas H
Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Stirrups Kathleen
Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Stolk Ronald P
University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.
Stringham Heather M
Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
Swertz Morris A
University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.
Swift Amy J
Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, United States of America.
Syvänen Ann-Christine
Science for Life Laboratory, Uppsala University, Uppsala, Sweden; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Tan Sian-Tsung
Ealing Hospital NHS Trust, Middlesex, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Thorand Barbara
Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany.
Tönjes Anke
University of Leipzig, Department of Medicine, Leipzig, Germany.
Tremblay Angelo
Department of Kinesiology, Laval University, Québec City, Québec, Canada.
Tsafantakis Emmanouil
Anogia Medical Centre, Anogia, Greece.
van der Most Peter J
University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.
Völker Uwe
Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Vohl Marie-Claude
Institute of Nutrition and Functional Foods, Laval University, Québec City, Québec, Canada; School of Nutrition, Laval University, Québec City, Québec,Canada.
Vonk Judith M
University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.
Waldenberger Melanie
DZHK (German Centre for Cardiovascular Research), partnersite Munich Heart Alliance, Munich, Germany; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Walker Ryan W
The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Wennauer Roman
Department of Clinical Chemistry, Ulm University Medical Centre, Ulm, Germany.
Widén Elisabeth
Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Willemsen Gonneke
Department of Biological Psychology, VU University, Amsterdam, The Netherlands.
Wilsgaard Tom
Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.
Wright Alan F
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland.
Zillikens M Carola
Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), The Netherlands; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
van Dijk Suzanne C
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
van Schoor Natasja M
EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands; VUMC, Department of Epidemiology and Biostatistics, Amsterdam, The Netherlands.
Asselbergs Folkert W
Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands; Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute, Utrecht, The Netherlands; Institute of Cardiovascular Science, University College London, London, United Kingdom.
de Bakker Paul I W
Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands; Department of Epidemiology, University Medical Center, Utrecht, The Netherlands.
Beckmann Jacques S
Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Beilby John
Pathwest Laboratory Medicine of Western Australia, Nedlands, Western Australia,Australia; School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Western Australia, Australia.
Bennett David A
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America.
Bergman Richard N
Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
Bergmann Sven
Swiss Institute of Bioinformatics, Lausanne, Switzerland; Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.
Böger Carsten A
Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.
Boehm Bernhard O
Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany; Imperial College London, London, United Kingdom; Lee Kong Chian School of Medicine, Singapore, Singapore; Nanyang Technological University, Singapore, Singapore.
Boerwinkle Eric
Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas, United States of America.
Boomsma Dorret I
Department of Biological Psychology, VU University, Amsterdam, The Netherlands.
Bornstein Stefan R
Department of Medicine III, University of Dresden, Medical Faculty Carl Gustav Carus, Dresden, Germany.
Bottinger Erwin P
The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Department of Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Bouchard Claude
Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.
Chambers John C
Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom; Ealing Hospital NHS Trust, Middlesex, United Kingdom; Imperial College Healthcare NHS Trust, London, United Kingdom.
Chanock Stephen J
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America; Program in Biostatistics and Biomathematics, Divison of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Chasman Daniel I
Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America; Harvard Medical School, Boston, Massachusetts,United States of America.
Cucca Francesco
Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato, Italy; University of Sassari, Sassari, Italy.
Cusi Daniele
Department of Health Sciences, University of Milan, Milan, Italy; Institute of Biomedical Technologies, National Institute of Research, Segrate-Milano, Italy.
Dedoussis George
Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Erdmann Jeanette
DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Lübeck, Germany; Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Lübeck, Germany.
Eriksson Johan G
National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland; Folkhälsan Research Centre, Helsinki, Finland; Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland.
Evans Denis A
Rush Institute for Healthy Aging and Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, United States of America.
de Faire Ulf
Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Farrall Martin
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom; Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands.
Ferrucci Luigi
Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, United States of America.
Ford Ian
Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom.
Franke Lude
University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, Netherlands.
Franks Paul W
Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden; Department of Public Health & Clinical Medicine, Umeå University Hospital, Umeå, Sweden, Umeå, Sweden; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America.
Froguel Philippe
CNRS UMR 8199, Lille, France; European Genomic Institute for Diabetes, Lille, France; Université de Lille 2, Lille, France.
Gansevoort Ron T
University of Groningen, University Medical Center Groningen, Department of Medicine, Groningen, Netherlands.
Gieger Christian
Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Grönberg Henrik
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Gudnason Vilmundur
Icelandic Heart Association, Kopavogur, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Gyllensten Ulf
Science for Life Laboratory, Uppsala University, Uppsala, Sweden; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Hall Per
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Hamsten Anders
Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
van der Harst Pim
University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, Netherlands; Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute, Utrecht, The Netherlands.
Hayward Caroline
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland.
Heliövaara Markku
Department of Health, National Institute for Health and Welfare, Helsinki, Finland.
Hengstenberg Christian
DZHK (German Centre for Cardiovascular Research), partnersite Munich Heart Alliance, Munich, Germany; Deutsches Herzzentrum München, Technische Universität München, München, Germany.
Hicks Andrew A
Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Affiliated Institute of the University of Lübeck, Lübeck, Germany.
Hingorani Aroon
Institute of Cardiovascular Science, University College London, London, United Kingdom.
Hofman Albert
Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Hu Frank
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
Huikuri Heikki V
Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, Finland.
Hveem Kristian
Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway.
James Alan L
Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
Jordan Joanne M
Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chaper Hill, North Carolina, United States of America.
Jula Antti
National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland.
Kähönen Mika
Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland; Department of Clinical Physiology, University of Tampere School of Medicine, Tampere, Finland.
Kajantie Eero
Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland; Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Kathiresan Sekar
Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America; Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America; Center for Human Genetics Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Kiemeney Lambertus A L M
Radboud university medical center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, The Netherlands; Radboud university medical center, Radboud Institute for Health Sciences, Department of Urology, Nijmegen, The Netherlands.
Kivimaki Mika
Department of Epidemiology and Public Health, UCL, London, United Kingdom.
Knekt Paul B
National Institute for Health and Welfare, Helsinki, Finland.
Koistinen Heikki A
National Institute for Health and Welfare, Helsinki, Finland; University of Helsinki and Helsinki University Central Hospital, Department of Medicine and Abdominal Center: Endocrinology, Helsinki, Finland; Minerva Foundation Institute for Medical Research, Helsinki, Finland.
Kooner Jaspal S
Ealing Hospital NHS Trust, Middlesex, United Kingdom; National Heart and Lung Institute, Imperial College London, London, United Kingdom; Imperial College Healthcare NHS Trust, London, United Kingdom.
Koskinen Seppo
Department of Health, National Institute for Health and Welfare, Helsinki, Finland.
Kuusisto Johanna
Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Maerz Winfried
Vth Department of Medicine, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
Martin Nicholas G
QIMR Bergofer Medical Research Institute, Brisbane, Queensland, Australia.
Laakso Markku
Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Lakka Timo A
Kuopio Research Institute of Exercise Medicine, Kuopio, Finland; Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
Lehtimäki Terho
Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland; Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere, Finland.
Lettre Guillaume
Montreal Heart Institute, Montréal, Québec, Canada; Department of Medicine, Université de Montréal, Montréal, Québec, Canada.
Levinson Douglas F
Stanford University, Stanford, California, United States of America.
Lind Lars
Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Lokki Marja-Liisa
Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland.
Mäntyselkä Pekka
Primary Health Care Unit, Institute of Public Health and Clinical Nutrition, School of Medicine, University of Eastern Finland, Kuopio, Finland; Primary Health Care Unit, Kuopio University Hospital, Kuopio, Finland.
Melbye Mads
Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America.
Metspalu Andres
Estonian Genome Center, Univeristy of Tartu, Tartu, Estonia.
Mitchell Braxton D
University of Maryland School of Medicine, Department of Medicine, Baltimore, Maryland, United States of America; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, Maryland, United States of America.
Moll Frans L
Department of Surgery, University Medical Center Utrecht, Utrecht, Netherlands.
Murray Jeffrey C
Department of Pediatrics, University of Iowa, Iowa City, Iowa, United States of America.
Musk Arthur W
Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
Nieminen Markku S
HUCH Heart and Lung Center, Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland.
Njølstad Inger
Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.
Ohlsson Claes
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Oldehinkel Albertine J
University of Groningen, University Medical Center, Interdisciplinary Center Psychopathology and Emotion Regulation, Groningen, The Netherlands.
Oostra Ben A
Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Palmer Lyle J
School of Public Health, University of Adelaide, Adelaide, South Australia, Australia; Robinson Research Institute, University of Adelaide, Adelaide, South Australia, Australia.
Pankow James S
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America.
Pasterkamp Gerard
Experimental Cardiology and laboratory of clinical chemistry, UMCU, Utrecht, The Netherlands.
Pedersen Nancy L
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Pedersen Oluf
Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Penninx Brenda W
Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands.
Perola Markus
Estonian Genome Center, Univeristy of Tartu, Tartu, Estonia; National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland; Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Peters Annette
DZHK (German Centre for Cardiovascular Research), partnersite Munich Heart Alliance, Munich, Germany; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Polašek Ozren
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland; Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia.
Pramstaller Peter P
Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy, Affiliated Institute of the University of Lübeck, Lübeck, Germany; Department of Neurology, General Central Hospital, Bolzano, Italy.
Psaty Bruce M
Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America; Department of Medicine, University of Washington, Seattle, Washington, United States of America; Departments of Epidemiology and Health Services, University of Washington, Seattle, Washington, United States of America; Group Health Research Institute, Group Health Cooperative, Seatte, Washington, United States of America.
Qi Lu
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
Quertermous Thomas
Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America.
Raitakari Olli T
Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Rankinen Tuomo
Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.
Rauramaa Rainer
Kuopio Research Institute of Exercise Medicine, Kuopio, Finland; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.
Ridker Paul M
Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America; Harvard Medical School, Boston, Massachusetts,United States of America.
Rioux John D
Montreal Heart Institute, Montréal, Québec, Canada; Department of Medicine, Université de Montréal, Montréal, Québec, Canada.
Rivadeneira Fernando
Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Rotter Jerome I
Los Angeles BioMedical Resesarch Institute at Harbor-UCLA Medical Center, Torrance, California, United States of America.
Rudan Igor
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland.
den Ruijter Hester M
Experimental Cardiology and laboratory of clinical chemistry, UMCU, Utrecht, The Netherlands.
Saltevo Juha
Department of Medicine, Central Finland Central Hospital, Jyväskylä, Finland.
Sattar Naveed
BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom.
Schunkert Heribert
DZHK (German Centre for Cardiovascular Research), partnersite Munich Heart Alliance, Munich, Germany; Deutsches Herzzentrum München, Technische Universität München, München, Germany.
Schwarz Peter E H
Department of Medicine III, University of Dresden, Medical Faculty Carl Gustav Carus, Dresden, Germany.
Shuldiner Alan R
Program for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes & Nutrition, Dept of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America; Geriatric Research and Education Clinical Center, Vetrans Administration Medical Center, Baltimore, Maryland, United States of America.
Sinisalo Juha
HUCH Heart and Lung Center, Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland.
Snieder Harold
University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.
Sørensen Thorkild I A
Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom; Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, The Capital Region, Frederiksberg, Denmark.
Spector Tim D
Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom.
Staessen Jan A
Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium; R & D VitaK Group, Maastricht University, Maastricht, The Netherlands.
Stefania Bandinelli
Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.
Thorsteinsdottir Unnur
deCODE Genetics, Amgen inc., Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Stumvoll Michael
University of Leipzig, IFB Adiposity Diseases, Leipzig, Germany; University of Leipzig, Department of Medicine, Leipzig, Germany.
Tardif Jean-Claude
Montreal Heart Institute, Montréal, Québec, Canada; Department of Medicine, Université de Montréal, Montréal, Québec, Canada.
Tremoli Elena
Centro Cardiologico Monzino, IRCCS, Milan, Italy; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy.
Tuomilehto Jaakko
Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland; Centre for Vascular Prevention, Danube-University Krems, Krems, Austria; Instituto de Investigacion Sanitaria del Hospital Universitario La Paz (IdiPAZ), Madrid, Spain; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.
Uitterlinden André G
Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
Uusitupa Matti
Department of Public Health and Clinical Nutrition, University of Eastern Finland, Finland; Research Unit, Kuopio University Hospital, Kuopio, Finland.
Verbeek André L M
Radboud university medical center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, The Netherlands.
Vermeulen Sita H
Radboud university medical center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, The Netherlands; Department of Human Genetics, Radboud university medical center, Nijmegen, The Netherlands.
Viikari Jorma S
Department of Medicine, University of Turku, Turku, Finland.
Vitart Veronique
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland.
Völzke Henry
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Vollenweider Peter
Department of Internal Medicine, University Hospital Lausanne (CHUV) and University of Lausanne, Lausanne, Switzerland.
Waeber Gérard
Department of Internal Medicine, University Hospital Lausanne (CHUV) and University of Lausanne, Lausanne, Switzerland.
Walker Mark
Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America; Institute of Cellular Medicine, Newcastle University, Newcastle, United Kingdom.
Wallaschofski Henri
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Wareham Nicholas J
MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.
Watkins Hugh
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Zeggini Eleftheria
Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom.
CHARGE Consortium
DIAGRAM Consortium
GLGC Consortium
Global-BPGen Consortium
ICBP Consortium
MAGIC Consortium
Chakravarti Aravinda
Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Clegg Deborah J
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.
Cupples L Adrienne
National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts, United States of America; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
Gordon-Larsen Penny
Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Jaquish Cashell E
National Heart, Lung, and Blood Institute, National Institute of Health, Bethesda, Maryland, United States of America.
Rao D C
Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Abecasis Goncalo R
Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
Assimes Themistocles L
Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America.
Barroso Inês
Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom; NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science Addenbrooke's Hospital, Cambridge, United Kingdom; University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science Addenbrooke's Hospital, Cambridge, United Kingdom.
Berndt Sonja I
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America.
Boehnke Michael
Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
Deloukas Panos
Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge, United Kingdom; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia.
Fox Caroline S
National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts, United States of America; Harvard Medical School, Boston, Massachusetts,United States of America.
Groop Leif C
Lund University Diabetes Centre and Department of Clinical Science, Diabetes & Endocrinology Unit, Lund University, Malmö, Sweden; Finnish Institute for Molecular Medicine (FIMM), Helsinki University, Helsinki, Finland.
Hunter David J
Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States of America; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America.
Ingelsson Erik
Science for Life Laboratory, Uppsala University, Uppsala, Sweden; Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, United States of America.
Kaplan Robert C
Department of Epidemiology and Popualtion Health, Albert Einstein College of Medicine, Bronx, New York, United States of America.
McCarthy Mark I
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, United Kingdom; Oxford NIHR Biomedical Research Centre, Oxford, United Kingdom.
Mohlke Karen L
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America.
O'Connell Jeffrey R
Program for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes & Nutrition, Dept of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.
Schlessinger David
National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America.
Strachan David P
Population Health Research Institute, St George's, University of London, London, United Kingdom.
Stefansson Kari
deCODE Genetics, Amgen inc., Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
van Duijn Cornelia M
Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands; Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), The Netherlands; Center for Medical Systems Biology, Leiden, The Netherlands.
Hirschhorn Joel N
Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States of America; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts, United States of America; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America.
Lindgren Cecilia M
Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States of America; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Heid Iris M
Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University Regensburg, Regensburg, Germany; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
North Kari E
Carolina Center for Genome Sciences and Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
Borecki Ingrid B
Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Kutalik Zoltán
Swiss Institute of Bioinformatics, Lausanne, Switzerland; Institute of Social and Preventive Medicine, University Hospital Lausanne (CHUV), Lausanne, Switzerland; Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.
Loos Ruth J F
MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
References (91)
91 references, click to expand
  1. Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study.
    Lancet. 2005 Nov 5;366(9497):1640-9 PMID: 16271645
  2. Genomic control for association studies.
    Biometrics. 1999 Dec;55(4):997-1004 PMID: 11315092
  3. SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap.
    Bioinformatics. 2008 Dec 15;24(24):2938-9 PMID: 18974171
  4. The influence of obesity-related single nucleotide polymorphisms on BMI across the life course: the PAGE study.
    Diabetes. 2013 May;62(5):1763-7 PMID: 23300277
  5. The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits.
    PLoS Genet. 2012;8(8):e1002793 PMID: 22876189
  6. Use of self-reported height and weight biases the body mass index-mortality association.
    Int J Obes (Lond). 2011 Mar;35(3):401-8 PMID: 20680015
  7. Common variants associated with plasma triglycerides and risk for coronary artery disease.
    Nat Genet. 2013 Nov;45(11):1345-52 PMID: 24097064
  8. Methods for testing association between uncertain genotypes and quantitative traits.
    Biostatistics. 2011 Jan;12(1):1-17 PMID: 20543033
  9. Common SNPs explain a large proportion of the heritability for human height.
    Nat Genet. 2010 Jul;42(7):565-9 PMID: 20562875
  10. GenABEL: an R library for genome-wide association analysis.
    Bioinformatics. 2007 May 15;23(10):1294-6 PMID: 17384015
  11. Precedence of bone loss over changes in body composition and body fat distribution within a few years after menopause.
    Maturitas. 2003 Oct 20;46(2):133-8 PMID: 14559384
  12. Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins.
    J Biol Chem. 2000 Aug 25;275(34):26458-66 PMID: 10843999
  13. Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.
    Am J Hum Genet. 2014 Jul 3;95(1):24-38 PMID: 24954895
  14. The disease burden associated with overweight and obesity.
    JAMA. 1999 Oct 27;282(16):1523-9 PMID: 10546691
  15. Clinical review 107: Role of gonadal steroids in the sexual dimorphisms in body composition and circulating concentrations of leptin.
    J Clin Endocrinol Metab. 1999 Jun;84(6):1784-9 PMID: 10372664
  16. Genotype imputation.
    Annu Rev Genomics Hum Genet. 2009;10:387-406 PMID: 19715440
  17. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001.
    JAMA. 2003 Jan 1;289(1):76-9 PMID: 12503980
  18. Life course variations in the associations between FTO and MC4R gene variants and body size.
    Hum Mol Genet. 2010 Feb 1;19(3):545-52 PMID: 19880856
  19. Identification of a novel modulator of thyroid hormone receptor-mediated action.
    PLoS One. 2007;2(11):e1183 PMID: 18030323
  20. Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development.
    PLoS Genet. 2011 Feb;7(2):e1001307 PMID: 21379325
  21. A new multipoint method for genome-wide association studies by imputation of genotypes.
    Nat Genet. 2007 Jul;39(7):906-13 PMID: 17572673
  22. Common genetic variation and performance on standardized cognitive tests.
    Eur J Hum Genet. 2010 Jul;18(7):815-20 PMID: 20125193
  23. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
    Hum Mol Genet. 2009 Dec 1;18(23):4650-61 PMID: 19734545
  24. Factors associated with age at natural menopause in a multiethnic sample of midlife women.
    Am J Epidemiol. 2001 May 1;153(9):865-74 PMID: 11323317
  25. Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    Nature. 2010 Oct 14;467(7317):832-8 PMID: 20881960
  26. Handling marker-marker linkage disequilibrium: pedigree analysis with clustered markers.
    Am J Hum Genet. 2005 Nov;77(5):754-67 PMID: 16252236
  27. Biological, clinical and population relevance of 95 loci for blood lipids.
    Nature. 2010 Aug 5;466(7307):707-13 PMID: 20686565
  28. Growth at puberty.
    J Adolesc Health. 2002 Dec;31(6 Suppl):192-200 PMID: 12470915
  29. Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course.
    Hum Mol Genet. 2013 Sep 1;22(17):3597-607 PMID: 23669352
  30. METAL: fast and efficient meta-analysis of genomewide association scans.
    Bioinformatics. 2010 Sep 1;26(17):2190-1 PMID: 20616382
  31. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
    Nat Genet. 2010 Nov;42(11):937-48 PMID: 20935630
  32. Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
    PLoS Genet. 2013 Jun;9(6):e1003500 PMID: 23754948
  33. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
    Nat Genet. 2010 Nov;42(11):949-60 PMID: 20935629
  34. Prospective study of the determinants of age at menopause.
    Am J Epidemiol. 1997 Jan 15;145(2):124-33 PMID: 9006309
  35. The role of PPARalpha in lipid metabolism and obesity: focusing on the effects of estrogen on PPARalpha actions.
    Pharmacol Res. 2009 Sep;60(3):151-9 PMID: 19646654
  36. Novel method to estimate the phenotypic variation explained by genome-wide association studies reveals large fraction of the missing heritability.
    Genet Epidemiol. 2011 Jul;35(5):341-9 PMID: 21465548
  37. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    Nat Genet. 2010 Dec;42(12):1118-25 PMID: 21102463
  38. Candidate gene association study of BMI-related loci, weight, and adiposity in old age.
    J Gerontol A Biol Sci Med Sci. 2013 Jun;68(6):661-6 PMID: 23160366
  39. Extrinsic and intrinsic regulation of DOR/TP53INP2 expression in mice: effects of dietary fat content, tissue type and sex in adipose and muscle tissues.
    Nutr Metab (Lond). 2012 Sep 21;9(1):86 PMID: 22995226
  40. Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.
    PLoS Genet. 2011 Aug;7(8):e1002197 PMID: 21829388
  41. General and abdominal adiposity and risk of death in Europe.
    N Engl J Med. 2008 Nov 13;359(20):2105-20 PMID: 19005195
  42. ProbABEL package for genome-wide association analysis of imputed data.
    BMC Bioinformatics. 2010;11:134 PMID: 20233392
  43. Glucocorticoid-induced androgen inactivation by aldo-keto reductase 1C2 promotes adipogenesis in human preadipocytes.
    Am J Physiol Endocrinol Metab. 2012 Apr 15;302(8):E941-9 PMID: 22275760
  44. Effect of puberty on body composition.
    Curr Opin Endocrinol Diabetes Obes. 2009 Feb;16(1):10-5 PMID: 19115520
  45. Estimation of genetic effects on BMI during adolescence in an ethnically diverse cohort: The National Longitudinal Study of Adolescent Health.
    Nutr Diabetes. 2012 Sep 24;2:e47 PMID: 23168566
  46. A genome-wide association meta-analysis identifies new childhood obesity loci.
    Nat Genet. 2012 May;44(5):526-31 PMID: 22484627
  47. Self-reported weight and height.
    Am J Clin Nutr. 1990 Dec;52(6):1125-33 PMID: 2239790
  48. Factors related to age at natural menopause: longitudinal analyses from SWAN.
    Am J Epidemiol. 2013 Jul 1;178(1):70-83 PMID: 23788671
  49. A microarray analysis of sexual dimorphism of adipose tissues in high-fat-diet-induced obese mice.
    Int J Obes (Lond). 2010 Jun;34(6):989-1000 PMID: 20157318
  50. MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes.
    Genet Epidemiol. 2010 Dec;34(8):816-34 PMID: 21058334
  51. Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
    Nat Genet. 2012 Sep;44(9):991-1005 PMID: 22885924
  52. New genetic loci link adipose and insulin biology to body fat distribution.
    Nature. 2015 Feb 12;518(7538):187-96 PMID: 25673412
  53. Relation between body fat and age in 4 ethnic groups.
    Am J Clin Nutr. 1999 May;69(5):1007-13 PMID: 10232643
  54. Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes.
    J Clin Invest. 2014 May;124(5):1914-27 PMID: 24713655
  55. Heritability and genomics of gene expression in peripheral blood.
    Nat Genet. 2014 May;46(5):430-7 PMID: 24728292
  56. Cohort Profile: Estonian Biobank of the Estonian Genome Center, University of Tartu.
    Int J Epidemiol. 2015 Aug;44(4):1137-47 PMID: 24518929
  57. Quality control and conduct of genome-wide association meta-analyses.
    Nat Protoc. 2014 May;9(5):1192-212 PMID: 24762786
  58. The effect of the menopausal transition on body composition and cardiometabolic risk factors: a Montreal-Ottawa New Emerging Team group study.
    Menopause. 2012 Jul;19(7):760-7 PMID: 22395454
  59. Genome-wide association study identifies eight loci associated with blood pressure.
    Nat Genet. 2009 Jun;41(6):666-76 PMID: 19430483
  60. Annotation of functional variation in personal genomes using RegulomeDB.
    Genome Res. 2012 Sep;22(9):1790-7 PMID: 22955989
  61. A network-based analysis of systemic inflammation in humans.
    Nature. 2005 Oct 13;437(7061):1032-7 PMID: 16136080
  62. Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies.
    Diabetes. 2010 Nov;59(11):2980-8 PMID: 20724581
  63. Precedence of the shift of body-fat distribution over the change in body composition after menopause.
    J Obstet Gynaecol Res. 2006 Oct;32(5):513-6 PMID: 16984520
  64. Body fat distribution and risk of coronary heart disease in men and women in the European Prospective Investigation Into Cancer and Nutrition in Norfolk cohort: a population-based prospective study.
    Circulation. 2007 Dec 18;116(25):2933-43 PMID: 18071080
  65. Genome-wide association study of hematological and biochemical traits in a Japanese population.
    Nat Genet. 2010 Mar;42(3):210-5 PMID: 20139978
  66. Practical issues in imputation-based association mapping.
    PLoS Genet. 2008 Dec;4(12):e1000279 PMID: 19057666
  67. PLINK: a tool set for whole-genome association and population-based linkage analyses.
    Am J Hum Genet. 2007 Sep;81(3):559-75 PMID: 17701901
  68. Beyond women's health the new discipline of gender-specific medicine.
    Med Clin North Am. 2003 Sep;87(5):917-37, vii PMID: 14621324
  69. Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm.
    Nat Protoc. 2009;4(7):1073-81 PMID: 19561590
  70. Increasing the power of identifying gene x gene interactions in genome-wide association studies.
    Genet Epidemiol. 2008 Apr;32(3):255-63 PMID: 18200600
  71. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    Nature. 2011 Aug 11;476(7359):214-9 PMID: 21833088
  72. New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
    Nat Genet. 2013 Jan;45(1):76-82 PMID: 23202124
  73. FTO, type 2 diabetes, and weight gain throughout adult life: a meta-analysis of 41,504 subjects from the Scandinavian HUNT, MDC, and MPP studies.
    Diabetes. 2011 May;60(5):1637-44 PMID: 21398525
  74. New gene functions in megakaryopoiesis and platelet formation.
    Nature. 2011 Dec 8;480(7376):201-8 PMID: 22139419
  75. A map of human genome variation from population-scale sequencing.
    Nature. 2010 Oct 28;467(7319):1061-73 PMID: 20981092
  76. GCTA: a tool for genome-wide complex trait analysis.
    Am J Hum Genet. 2011 Jan 7;88(1):76-82 PMID: 21167468
  77. Genomics, type 2 diabetes, and obesity.
    N Engl J Med. 2010 Dec 9;363(24):2339-50 PMID: 21142536
  78. Genome-wide meta-analysis of joint tests for genetic and gene-environment interaction effects.
    Hum Hered. 2010;70(4):292-300 PMID: 21293137
  79. Comparison of body mass index, waist circumference, and waist/hip ratio in predicting incident diabetes: a meta-analysis.
    Epidemiol Rev. 2007;29:115-28 PMID: 17494056
  80. Genetic studies of body mass index yield new insights for obesity biology.
    Nature. 2015 Feb 12;518(7538):197-206 PMID: 25673413
  81. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
    Nat Genet. 2012 May;44(5):491-501 PMID: 22504420
  82. Sex differences in the human peripheral blood transcriptome.
    BMC Genomics. 2014;15:33 PMID: 24438232
  83. Biological interpretation of genome-wide association studies using predicted gene functions.
    Nat Commun. 2015;6:5890 PMID: 25597830
  84. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
    Nat Genet. 2012 Sep;44(9):981-90 PMID: 22885922
  85. Type 2 diabetes and obesity: genomics and the clinic.
    Hum Genet. 2011 Jul;130(1):41-58 PMID: 21647602
  86. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data.
    Nucleic Acids Res. 2010 Sep;38(16):e164 PMID: 20601685
  87. Adult obesity susceptibility variants are associated with greater childhood weight gain and a faster tempo of growth: the 1946 British Birth Cohort Study.
    Am J Clin Nutr. 2012 May;95(5):1150-6 PMID: 22456663
  88. Validity of self-reported height and weight and predictors of bias in adolescents.
    J Adolesc Health. 2005 Nov;37(5):371-5 PMID: 16227121
  89. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
    Schizophr Res. 2010 Dec;124(1-3):192-9 PMID: 20889312
  90. Sexual dimorphism of body composition.
    Best Pract Res Clin Endocrinol Metab. 2007 Sep;21(3):415-30 PMID: 17875489
  91. Age-related changes in total and regional fat distribution.
    Ageing Res Rev. 2009 Oct;8(4):339-48 PMID: 19576300
Article Info
Journal
PLoS genetics
Abbr.
PLoS Genet
ISSN
1553-7404
DOI
10.1371/journal.pgen.1005378
Published
2015-10-00
Epub
2015-00-01
Pages
e1005378
Language
English
Region
United States
NLM ID
101239074
PMCID
PMC4591371
Subset
IM
Grants
NIDDK NIH HHS · R01 DK072193 · United States
NIMH NIH HHS · RC2 MH089951 · United States
NIMH NIH HHS · R01 MH061675 · United States
NHLBI NIH HHS · U01 HL105198 · United States
NIDDK NIH HHS · R01 DK093757 · United States
NHLBI NIH HHS · N01HC55020 · United States
Medical Research Council · G1001799 · United Kingdom
NHLBI NIH HHS · R01 HL103612 · United States
Wellcome Trust · 098017 · United Kingdom
NIMH NIH HHS · R01 MH063706 · United States
NIAAA NIH HHS · R01 AA007535 · United States
British Heart Foundation · RG/13/2/30098 · United Kingdom
NINDS NIH HHS · R01 NS045012 · United States
NIAMS NIH HHS · P60 AR049465 · United States
NHGRI NIH HHS · U01 HG004438 · United States
NIA NIH HHS · N01AG12100 · United States
NIAAA NIH HHS · R01 AA014041 · United States
NIMH NIH HHS · R01 MH081802 · United States
NIA NIH HHS · RF1 AG015819 · United States
NHGRI NIH HHS · N01HG65403 · United States
NHGRI NIH HHS · U01 HG004446 · United States
Medical Research Council · MR/K002414/1 · United Kingdom
NHLBI NIH HHS · R01 HL120393 · United States
NHLBI NIH HHS · N01HC55018 · United States
NHLBI NIH HHS · R01 HL036310 · United States
NHLBI NIH HHS · R01 HL087647 · United States
NHLBI NIH HHS · U01 HL084729 · United States
Medical Research Council · G0600705 · United Kingdom
Medical Research Council · MC_UP_A100_1003 · United Kingdom
NCRR NIH HHS · UL1 RR025005 · United States
NHLBI NIH HHS · R01 HL087679 · United States
Medical Research Council · G0000934 · United Kingdom
NHLBI NIH HHS · U01 HL080295 · United States
NIMH NIH HHS · RC2 MH089995 · United States
NHLBI NIH HHS · R01 HL087676 · United States
NIAMS NIH HHS · P60 AR030701 · United States
NHGRI NIH HHS · R01 HG002651 · United States
NHLBI NIH HHS · R01 HL043851 · United States
NHLBI NIH HHS · R01 HL059367 · United States
NIMHD NIH HHS · R01 MD009164 · United States
NIA NIH HHS · R01 AG030146 · United States
NHLBI NIH HHS · HHSN268200800007C · United States
Medical Research Council · G0700931 · United Kingdom
NHLBI NIH HHS · R01 HL086694 · United States
NIMH NIH HHS · U01 MH079469 · United States
NHLBI NIH HHS · T32 HL091823 · United States
NIDDK NIH HHS · R01 DK091718 · United States
NIA NIH HHS · R01 AG008724 · United States
Medical Research Council · MC_UU_12019/1 · United Kingdom
NIAAA NIH HHS · R01 AA013326 · United States
Medical Research Council · G1000143 · United Kingdom
Versus Arthritis · 20308 · United Kingdom
NIA NIH HHS · R01 AG017917 · United States
NHGRI NIH HHS · T32 HG000040 · United States
Medical Research Council · G1002319 · United Kingdom
NIDA NIH HHS · R56 DA012854 · United States
NHLBI NIH HHS · R01 HL087652 · United States
NHGRI NIH HHS · U01 HG004402 · United States
NHLBI NIH HHS · N01HC55022 · United States
NIDDK NIH HHS · R01 DK075787 · United States
NCATS NIH HHS · UL1 TR000124 · United States
NHLBI NIH HHS · N01HC55222 · United States
NHLBI NIH HHS · N02HL64278 · United States
NIDDK NIH HHS · R01 DK075681 · United States
NHLBI NIH HHS · N01HC55015 · United States
Medical Research Council · G0601966 · United Kingdom
NHLBI NIH HHS · N01HC85086 · United States
Medical Research Council · MC_UU_12015/1 · United Kingdom
NIMH NIH HHS · R01 MH067257 · United States
NIAAA NIH HHS · R01 AA013321 · United States
NIDDK NIH HHS · R01 DK062370 · United States
NHLBI NIH HHS · R01 HL105756 · United States
Medical Research Council · MC_U106179471 · United Kingdom
NIMH NIH HHS · R01 MH060870 · United States
NIMH NIH HHS · R01 MH081800 · United States
NIA NIH HHS · R37 AG013196 · United States
NIDDK NIH HHS · P30 DK046200 · United States
NIDDK NIH HHS · U01 DK062418 · United States
NIA NIH HHS · R01 AG028555 · United States
Medical Research Council · MR/N01104X/1 · United Kingdom
NHLBI NIH HHS · U01 HL084756 · United States
NIDDK NIH HHS · P30 DK063491 · United States
NIMH NIH HHS · R01 MH059571 · United States
NHGRI NIH HHS · HHSN268200782096C · United States
NIMH NIH HHS · R01 MH059565 · United States
Medical Research Council · MC_UU_12015/2 · United Kingdom
NHLBI NIH HHS · HHSN268201200036C · United States
NIA NIH HHS · P30 AG010161 · United States
NIDDK NIH HHS · P30 DK072488 · United States
Cancer Research UK · 14136 · United Kingdom
Medical Research Council · MC_U106179472 · United Kingdom
NINDS NIH HHS · U01 NS069208 · United States
Medical Research Council · G0401527 · United Kingdom
NIMH NIH HHS · U01 MH079470 · United States
NIMH NIH HHS · R01 MH059587 · United States
Intramural NIH HHS · Z01 HG000024 · United States
NIDDK NIH HHS · P30 DK020541 · United States
NHLBI NIH HHS · N01HC55016 · United States
Medical Research Council · MC_PC_U127561128 · United Kingdom
NHLBI NIH HHS · U01 HL072515 · United States
NIMH NIH HHS · U24 MH068457 · United States
NCI NIH HHS · UM1 CA182913 · United States
NCI NIH HHS · U01 CA098233 · United States
NCRR NIH HHS · M01 RR016500 · United States
NIDA NIH HHS · R01 DA012854 · United States
Wellcome Trust · 098395 · United Kingdom
NIMH NIH HHS · R01 MH059586 · United States
Versus Arthritis · 20109 · United Kingdom
NIDDK NIH HHS · U01 DK062370 · United States
NHLBI NIH HHS · R01 HL071981 · United States
NCI NIH HHS · R01 CA047988 · United States
NIA NIH HHS · N01AG12109 · United States
NHLBI NIH HHS · N01HC55019 · United States
NHLBI NIH HHS · R01 HL080467 · United States
NHLBI NIH HHS · N01HC85082 · United States
NHGRI NIH HHS · U01 HG004436 · United States
NIDDK NIH HHS · R01 DK089256 · United States
Medical Research Council · MR/K013351/1 · United Kingdom
NIA NIH HHS · R01 AG013196 · United States
NHLBI NIH HHS · N01HC85083 · United States
NHLBI NIH HHS · N01HC25195 · United States
NIDDK NIH HHS · P30 DK020572 · United States
NIDDK NIH HHS · P60 DK020541 · United States
NIMH NIH HHS · R01 MH059566 · United States
Medical Research Council · MC_UU_12015/5 · United Kingdom
Wellcome Trust · United Kingdom
NIA NIH HHS · R01 AG011101 · United States
NIA NIH HHS · T32 AG000219 · United States
NHGRI NIH HHS · U01 HG004423 · United States
NIMH NIH HHS · RL1 MH083268 · United States
NIMH NIH HHS · R01 MH059588 · United States
NHLBI NIH HHS · N01HC85079 · United States
Wellcome Trust · 098381 · United Kingdom
NIAMS NIH HHS · F32 AR059469 · United States
NHLBI NIH HHS · R01 HL117078 · United States
NHLBI NIH HHS · N01HC55021 · United States
NIA NIH HHS · R01 AG023629 · United States
NHLBI NIH HHS · R01 HL087641 · United States
NICHD NIH HHS · P2C HD050924 · United States
NHLBI NIH HHS · T32 HL007055 · United States
NHLBI NIH HHS · N01HC85080 · United States
NIA NIH HHS · R01 AG010175 · United States
NIGMS NIH HHS · U01 GM074518 · United States
NIA NIH HHS · R56 AG023629 · United States
NCRR NIH HHS · U54 RR020278 · United States
NIA NIH HHS · R01 AG015819 · United States
NIMH NIH HHS · R01 MH060879 · United States
NIAAA NIH HHS · R01 AA013320 · United States
NHLBI NIH HHS · N01HC85081 · United States
NHLBI NIH HHS · R01 HL045670 · United States
British Heart Foundation · RG/10/12/28456 · United Kingdom
Corrections
ErratumIn
PMID: 27355579
External Links
PubMed source DOI: 10.1371/journal.pgen.1005378 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2