Home LiteratureArticle Details
PMID: 26845196 Published · ppublish English Journal Article Review Research Support, Non-U.S. Gov't

Actomyosin ring driven cytokinesis in budding yeast.

Seminars in cell & developmental biology ·Vol. 53 ·2016-00-00 ·Pages 19-27

Meitinger F, Palani S

Abstract

Cytokinesis is the final process in the cell cycle that physically divides one cell into two. In budding yeast, cytokinesis is driven by a contractile actomyosin ring (AMR) and the simultaneous formation of a primary septum, which serves as template for cell wall deposition. AMR assembly, constriction, primary septum formation and cell wall deposition are successive processes and tightly coupled to cell cycle progression to ensure the correct distribution of genetic material and cell organelles among the two rising cells prior to cell division. The role of the AMR in cytokinesis and the molecular mechanisms that drive AMR constriction and septation are the focus of current research. This review summarizes the recent progresses in our understanding of how budding yeast cells orchestrate the multitude of molecular mechanisms that control AMR driven cytokinesis in a spatio-temporal manner to achieve an error free cell division.

Keywords
Actomyosin-ring Budding yeast Cell division Cytokinesis
MeSH Terms
Actomyosin/metabolism Cytokinesis Models, Biological Saccharomycetales/cytology,metabolism,ultrastructure
Chemicals
Actomyosin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Meitinger Franz
Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California San Diego, 9500 Gilman Drive, CMM East, La Jolla, CA 92093, United States. Electronic address: [email protected].
Palani Saravanan
Division of Biomedical Cell Biology, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom. Electronic address: [email protected].
References (127)
127 references, click to expand
  1. Septins: molecular partitioning and the generation of cellular asymmetry.
    Cell Div. 2009 Aug 26;4:18 PMID: 19709431
  2. The function of chitin synthases 2 and 3 in the Saccharomyces cerevisiae cell cycle.
    J Cell Biol. 1991 Jul;114(1):111-23 PMID: 2050738
  3. Mechanisms for concentrating Rho1 during cytokinesis.
    Genes Dev. 2009 Apr 1;23(7):810-23 PMID: 19339687
  4. Inn1 and Cyk3 regulate chitin synthase during cytokinesis in budding yeasts.
    J Cell Sci. 2012 Nov 15;125(Pt 22):5453-66 PMID: 22956544
  5. Saccharomyces cerevisiae septins: supramolecular organization of heterooligomers and the mechanism of filament assembly.
    Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8274-9 PMID: 18550837
  6. Differential trafficking and timed localization of two chitin synthase proteins, Chs2p and Chs3p.
    J Cell Biol. 1996 Nov;135(3):597-610 PMID: 8909536
  7. Stt4 PI 4-kinase localizes to the plasma membrane and functions in the Pkc1-mediated MAP kinase cascade.
    Dev Cell. 2002 May;2(5):593-605 PMID: 12015967
  8. The Carboxy-Terminal Tails of Septins Cdc11 and Shs1 Recruit Myosin-II Binding Factor Bni5 to the Bud Neck in Saccharomyces cerevisiae.
    Genetics. 2015 Jul;200(3):843-62 PMID: 25971666
  9. The Tem1 small GTPase controls actomyosin and septin dynamics during cytokinesis.
    J Cell Sci. 2001 Apr;114(Pt 7):1379-86 PMID: 11257003
  10. Roles of Hof1p, Bni1p, Bnr1p, and myo1p in cytokinesis in Saccharomyces cerevisiae.
    Mol Biol Cell. 2000 Feb;11(2):593-611 PMID: 10679017
  11. Degradation of Hof1 by SCF(Grr1) is important for actomyosin contraction during cytokinesis in yeast.
    EMBO J. 2005 Apr 6;24(7):1440-52 PMID: 15775961
  12. The multiple roles of Cyk1p in the assembly and function of the actomyosin ring in budding yeast.
    Mol Biol Cell. 1999 Feb;10(2):283-96 PMID: 9950677
  13. Mechanisms of cytokinesis in budding yeast.
    Cytoskeleton (Hoboken). 2012 Oct;69(10):710-26 PMID: 22736599
  14. Actin depolymerization drives actomyosin ring contraction during budding yeast cytokinesis.
    Dev Cell. 2012 Jun 12;22(6):1247-60 PMID: 22698284
  15. Genetic control of the cell division cycle in yeast. IV. Genes controlling bud emergence and cytokinesis.
    Exp Cell Res. 1971 Dec;69(2):265-76 PMID: 4950437
  16. Cell cycle-regulated trafficking of Chs2 controls actomyosin ring stability during cytokinesis.
    Mol Biol Cell. 2005 May;16(5):2529-43 PMID: 15772160
  17. The power of MEN in cytokinesis.
    Cell Cycle. 2012 Jan 15;11(2):219-28 PMID: 22189712
  18. The Saccharomyces cerevisiae FKS1 (ETG1) gene encodes an integral membrane protein which is a subunit of 1,3-beta-D-glucan synthase.
    Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12907-11 PMID: 7528927
  19. Rho1 directs formin-mediated actin ring assembly during budding yeast cytokinesis.
    Curr Biol. 2002 Oct 29;12(21):1864-70 PMID: 12419188
  20. Yeast Lrg1p acts as a specialized RhoGAP regulating 1,3-beta-glucan synthesis.
    Yeast. 2001 Jul;18(10):943-51 PMID: 11447600
  21. Distinct roles of Rho1, Cdc42, and Cyk3 in septum formation and abscission during yeast cytokinesis.
    J Cell Biol. 2013 Jul 22;202(2):311-29 PMID: 23878277
  22. Dynamics of the contractile ring.
    Soc Gen Physiol Ser. 1975;30:305-34 PMID: 127386
  23. Architecture and dynamic remodelling of the septin cytoskeleton during the cell cycle.
    Nat Commun. 2014 Dec 05;5:5698 PMID: 25474997
  24. Cyk3 acts in actomyosin ring independent cytokinesis by recruiting Inn1 to the yeast bud neck.
    Mol Genet Genomics. 2009 Oct;282(4):437-51 PMID: 19707790
  25. Stepwise and cooperative assembly of a cytokinetic core complex in Saccharomyces cerevisiae.
    J Cell Sci. 2014 Aug 15;127(Pt 16):3614-24 PMID: 24895401
  26. Biphasic targeting and cleavage furrow ingression directed by the tail of a myosin II.
    J Cell Biol. 2010 Dec 27;191(7):1333-50 PMID: 21173112
  27. A myosin light chain mediates the localization of the budding yeast IQGAP-like protein during contractile ring formation.
    Curr Biol. 2000 Jun 15;10(12):727-30 PMID: 10873803
  28. A memory system of negative polarity cues prevents replicative aging.
    Cell. 2014 Nov 20;159(5):1056-69 PMID: 25416945
  29. Identification of Cdk targets that control cytokinesis.
    EMBO J. 2015 Jan 2;34(1):81-96 PMID: 25371407
  30. Identification of yeast IQGAP (Iqg1p) as an anaphase-promoting-complex substrate and its role in actomyosin-ring-independent cytokinesis.
    Mol Biol Cell. 2007 Dec;18(12 ):5139-53 PMID: 17942599
  31. The anaphase-promoting complex promotes actomyosin-ring disassembly during cytokinesis in yeast.
    Mol Biol Cell. 2009 Feb;20(4):1201-12 PMID: 19109423
  32. Cytokinesis: placing and making the final cut.
    Cell. 2007 Nov 30;131(5):847-60 PMID: 18045532
  33. The role of Bni5 in the regulation of septin higher-order structure formation.
    Biol Chem. 2015 Dec;396(12):1325-37 PMID: 26351911
  34. Immobile myosin-II plays a scaffolding role during cytokinesis in budding yeast.
    J Cell Biol. 2013 Feb 4;200(3):271-86 PMID: 23358243
  35. Movement of yeast 1,3-beta-glucan synthase is essential for uniform cell wall synthesis.
    Genes Cells. 2002 Jan;7(1):1-9 PMID: 11856368
  36. Mitotic exit kinase Dbf2 directly phosphorylates chitin synthase Chs2 to regulate cytokinesis in budding yeast.
    Mol Biol Cell. 2012 Jul;23(13):2445-56 PMID: 22573892
  37. Cytokinesis in animal cells.
    Cold Spring Harb Perspect Biol. 2015 Feb 13;7(4):a015834 PMID: 25680833
  38. EGT2 gene transcription is induced predominantly by Swi5 in early G1.
    Mol Cell Biol. 1996 Jul;16(7):3264-74 PMID: 8668141
  39. A Förster Resonance Energy Transfer (FRET)-based System Provides Insight into the Ordered Assembly of Yeast Septin Hetero-octamers.
    J Biol Chem. 2015 Nov 20;290(47):28388-401 PMID: 26416886
  40. Sho1p connects the plasma membrane with proteins of the cytokinesis network through multiple isomeric interaction states.
    J Cell Sci. 2012 Sep 1;125(Pt 17):4103-13 PMID: 22623719
  41. Dephosphorylation of Iqg1 by Cdc14 regulates cytokinesis in budding yeast.
    Mol Biol Cell. 2015 Aug 15;26(16):2913-26 PMID: 26085509
  42. Three-dimensional ultrastructure of the septin filament network in Saccharomyces cerevisiae.
    Mol Biol Cell. 2012 Feb;23(3):423-32 PMID: 22160597
  43. Arrangement of actin filaments and myosin-like filaments in the contractile ring and of actin-like filaments in the mitotic spindle of dividing HeLa cells.
    J Ultrastruct Mol Struct Res. 1986 Jan;94(1):92-103 PMID: 3772181
  44. Stress generation and filament turnover during actin ring constriction.
    PLoS One. 2007 Aug 08;2(8):e696 PMID: 17684545
  45. Fungal cell wall chitinases and glucanases.
    Microbiology. 2004 Jul;150(Pt 7):2029-35 PMID: 15256547
  46. Yeast formins Bni1 and Bnr1 utilize different modes of cortical interaction during the assembly of actin cables.
    Mol Biol Cell. 2007 May;18(5):1826-38 PMID: 17344480
  47. The evolution, complex structures and function of septin proteins.
    Cell Mol Life Sci. 2009 Oct;66(20):3309-23 PMID: 19597764
  48. Eng1p, an endo-1,3-beta-glucanase localized at the daughter side of the septum, is involved in cell separation in Saccharomyces cerevisiae.
    Eukaryot Cell. 2002 Oct;1(5):774-86 PMID: 12455695
  49. Cytokinesis and cancer.
    FEBS Lett. 2010 Jun 18;584(12):2652-61 PMID: 20371245
  50. Cdc14-dependent dephosphorylation of Inn1 contributes to Inn1-Cyk3 complex formation.
    J Cell Sci. 2012 Jul 1;125(Pt 13):3091-6 PMID: 22454527
  51. Comparison of Saccharomyces cerevisiae F-BAR domain structures reveals a conserved inositol phosphate binding site.
    Structure. 2015 Feb 3;23(2):352-63 PMID: 25620000
  52. Cyk3, a novel SH3-domain protein, affects cytokinesis in yeast.
    Curr Biol. 2000 Jul 27-Aug 10;10(15):947-50 PMID: 10959846
  53. Biosynthesis of cell wall and septum during yeast growth.
    Arch Med Res. 1993 Autumn;24(3):301-3 PMID: 8298281
  54. Exit from mitosis triggers Chs2p transport from the endoplasmic reticulum to mother-daughter neck via the secretory pathway in budding yeast.
    J Cell Biol. 2006 Jul 17;174(2):207-20 PMID: 16847101
  55. Identification and functional analysis of the essential and regulatory light chains of the only type II myosin Myo1p in Saccharomyces cerevisiae.
    J Cell Biol. 2004 Jun 21;165(6):843-55 PMID: 15210731
  56. Chitin synthetase 2, a presumptive participant in septum formation in Saccharomyces cerevisiae.
    J Biol Chem. 1986 Nov 15;261(32):15147-52 PMID: 2945823
  57. Comparative analysis of cytokinesis in budding yeast, fission yeast and animal cells.
    Curr Biol. 2004 Sep 21;14(18):R806-18 PMID: 15380095
  58. Targeted localization of Inn1, Cyk3 and Chs2 by the mitotic-exit network regulates cytokinesis in budding yeast.
    J Cell Sci. 2010 Jun 1;123(Pt 11):1851-61 PMID: 20442249
  59. Lre1 directly inhibits the NDR/Lats kinase Cbk1 at the cell division site in a phosphorylation-dependent manner.
    Curr Biol. 2013 Sep 23;23(18):1736-45 PMID: 23954433
  60. Cell cycle control of septin ring dynamics in the budding yeast.
    Microbiology. 2001 Jun;147(Pt 6):1437-50 PMID: 11390675
  61. Cell-sized spherical confinement induces the spontaneous formation of contractile actomyosin rings in vitro.
    Nat Cell Biol. 2015 Apr;17(4):480-9 PMID: 25799060
  62. Shs1p: a novel member of septin that interacts with spa2p, involved in polarized growth in saccharomyces cerevisiae.
    Biochem Biophys Res Commun. 1998 Oct 29;251(3):732-6 PMID: 9790978
  63. Architecture and biosynthesis of the Saccharomyces cerevisiae cell wall.
    Genetics. 2012 Nov;192(3):775-818 PMID: 23135325
  64. An actin nucleation mechanism mediated by Bni1 and profilin.
    Nat Cell Biol. 2002 Aug;4(8):626-31 PMID: 12134165
  65. Yeast myosin light chain, Mlc1p, interacts with both IQGAP and class II myosin to effect cytokinesis.
    J Cell Sci. 2000 Dec;113 Pt 24:4533-43 PMID: 11082046
  66. Inn1 couples contraction of the actomyosin ring to membrane ingression during cytokinesis in budding yeast.
    Nat Cell Biol. 2008 Apr;10(4):395-406 PMID: 18344988
  67. Overlapping and distinct roles of the duplicated yeast transcription factors Ace2p and Swi5p.
    Mol Microbiol. 2001 Apr;40(2):422-32 PMID: 11309124
  68. Formins direct Arp2/3-independent actin filament assembly to polarize cell growth in yeast.
    Nat Cell Biol. 2002 Jan;4(1):32-41 PMID: 11740490
  69. Involvement of an actomyosin contractile ring in Saccharomyces cerevisiae cytokinesis.
    J Cell Biol. 1998 Sep 7;142(5):1301-12 PMID: 9732290
  70. Identification of yeast Rho1p GTPase as a regulatory subunit of 1,3-beta-glucan synthase.
    Science. 1996 Apr 12;272(5259):279-81 PMID: 8602515
  71. Myosin‑II heavy chain and formin mediate the targeting of myosin essential light chain to the division site before and during cytokinesis.
    Mol Biol Cell. 2015 Apr 1;26(7):1211-24 PMID: 25631819
  72. Bni5p, a septin-interacting protein, is required for normal septin function and cytokinesis in Saccharomyces cerevisiae.
    Mol Cell Biol. 2002 Oct;22(19):6906-20 PMID: 12215547
  73. Comprehensive Genetic Analysis of Paralogous Terminal Septin Subunits Shs1 and Cdc11 in Saccharomyces cerevisiae.
    Genetics. 2015 Jul;200(3):821-41 PMID: 25971665
  74. Cofilin recruitment and function during actin-mediated endocytosis dictated by actin nucleotide state.
    J Cell Biol. 2007 Sep 24;178(7):1251-64 PMID: 17875745
  75. Cytokinesis depends on the motor domains of myosin-II in fission yeast but not in budding yeast.
    Mol Biol Cell. 2005 Nov;16(11):5346-55 PMID: 16148042
  76. Chitinase is required for cell separation during growth of Saccharomyces cerevisiae.
    J Biol Chem. 1991 Oct 15;266(29):19758-67 PMID: 1918080
  77. Structural memory in the contractile ring makes the duration of cytokinesis independent of cell size.
    Cell. 2009 May 29;137(5):926-37 PMID: 19490897
  78. Targeting and functional mechanisms of the cytokinesis-related F-BAR protein Hof1 during the cell cycle.
    Mol Biol Cell. 2013 May;24(9):1305-20 PMID: 23468521
  79. Global analysis of Cdc14 phosphatase reveals diverse roles in mitotic processes.
    J Biol Chem. 2011 Feb 18;286(7):5434-45 PMID: 21127052
  80. Septin structure and function in yeast and beyond.
    Trends Cell Biol. 2011 Mar;21(3):141-8 PMID: 21177106
  81. Inhibition of Cdc42 during mitotic exit is required for cytokinesis.
    J Cell Biol. 2013 Jul 22;202(2):231-40 PMID: 23878274
  82. Cdk1-dependent phosphorylation of Iqg1 governs actomyosin ring assembly prior to cytokinesis.
    J Cell Sci. 2014 Mar 1;127(Pt 5):1128-37 PMID: 24413167
  83. Role of Inn1 and its interactions with Hof1 and Cyk3 in promoting cleavage furrow and septum formation in S. cerevisiae.
    J Cell Biol. 2009 Jun 15;185(6):995-1012 PMID: 19528296
  84. Phosphorylation of Chs2p regulates interaction with COPII.
    J Cell Sci. 2013 May 15;126(Pt 10):2151-6 PMID: 23525003
  85. An IQGAP-related protein controls actin-ring formation and cytokinesis in yeast.
    Curr Biol. 1997 Dec 1;7(12):921-9 PMID: 9382845
  86. The yeast formin Bnr1p has two localization regions that show spatially and temporally distinct association with septin structures.
    Mol Biol Cell. 2010 Apr 1;21(7):1253-62 PMID: 20147448
  87. Role of formins in actin assembly: nucleation and barbed-end association.
    Science. 2002 Jul 26;297(5581):612-5 PMID: 12052901
  88. The contractile ring. II. Determining its brief existence, volumetric changes, and vital role in cleaving Arbacia eggs.
    J Cell Biol. 1972 May;53(2):419-34 PMID: 5063470
  89. A safeguard mechanism regulates Rho GTPases to coordinate cytokinesis with the establishment of cell polarity.
    PLoS Biol. 2013;11(2):e1001495 PMID: 23468594
  90. Isolation of Cytokinetic Actomyosin Rings from Saccharomyces cerevisiae and Schizosaccharomyces pombe.
    Methods Mol Biol. 2016;1369:125-36 PMID: 26519310
  91. Regulation of septin organization and function in yeast.
    Trends Cell Biol. 2003 Aug;13(8):403-9 PMID: 12888292
  92. Disruption of LRG1 inhibits mother-daughter separation in Saccharomyces cerevisiae.
    Yeast. 2005 Oct 30;22(14):1117-32 PMID: 16240460
  93. Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis.
    Science. 2006 Jul 7;313(5783):108-11 PMID: 16763112
  94. Cell wall assembly in Saccharomyces cerevisiae.
    Microbiol Mol Biol Rev. 2006 Jun;70(2):317-43 PMID: 16760306
  95. Tropomyosin is essential in yeast, yet the TPM1 and TPM2 products perform distinct functions.
    J Cell Biol. 1995 Feb;128(3):383-92 PMID: 7844152
  96. Mlc1p is a light chain for the unconventional myosin Myo2p in Saccharomyces cerevisiae.
    J Cell Biol. 1998 Aug 10;142(3):711-22 PMID: 9700160
  97. The Cbk1p pathway is important for polarized cell growth and cell separation in Saccharomyces cerevisiae.
    Mol Cell Biol. 2001 Apr;21(7):2449-62 PMID: 11259593
  98. Phosphorylation-dependent regulation of the F-BAR protein Hof1 during cytokinesis.
    Genes Dev. 2011 Apr 15;25(8):875-88 PMID: 21498574
  99. The yeasts Rho1p and Pkc1p regulate the transport of chitin synthase III (Chs3p) from internal stores to the plasma membrane.
    Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10287-92 PMID: 12928491
  100. Sequential assembly of myosin II, an IQGAP-like protein, and filamentous actin to a ring structure involved in budding yeast cytokinesis.
    J Cell Biol. 1998 Jan 26;140(2):355-66 PMID: 9442111
  101. Regulated nuclear localisation of the yeast transcription factor Ace2p controls expression of chitinase (CTS1) in Saccharomyces cerevisiae.
    Mol Gen Genet. 1999 Sep;262(2):275-82 PMID: 10517323
  102. Phosphatidylinositol-4,5-bisphosphate promotes budding yeast septin filament assembly and organization.
    J Mol Biol. 2010 Dec 10;404(4):711-31 PMID: 20951708
  103. IQGAP Family Members in Yeast, Dictyostelium, and Mammalian Cells.
    Int J Cell Biol. 2012;2012:894817 PMID: 22505937
  104. Role of a Cdc42p effector pathway in recruitment of the yeast septins to the presumptive bud site.
    Mol Biol Cell. 2006 Mar;17(3):1110-25 PMID: 16371506
  105. The yeast actin cytoskeleton: from cellular function to biochemical mechanism.
    Microbiol Mol Biol Rev. 2006 Sep;70(3):605-45 PMID: 16959963
  106. In vitro activity of 1,3-beta-D-glucan synthase requires the GTP-binding protein Rho1.
    J Biol Chem. 1996 Jun 14;271(24):14604-9 PMID: 8662910
  107. Dual function of the NDR-kinase Dbf2 in the regulation of the F-BAR protein Hof1 during cytokinesis.
    Mol Biol Cell. 2013 May;24(9):1290-304 PMID: 23447700
  108. Bni1p implicated in cytoskeletal control is a putative target of Rho1p small GTP binding protein in Saccharomyces cerevisiae.
    EMBO J. 1996 Nov 15;15(22):6060-8 PMID: 8947028
  109. Three-dimensional arrangement of F-actin in the contractile ring of fission yeast.
    J Cell Biol. 2007 Aug 27;178(5):765-71 PMID: 17724118
  110. Actin network architecture can determine myosin motor activity.
    Science. 2012 Jun 8;336(6086):1310-4 PMID: 22679097
  111. In vitro contraction of cytokinetic ring depends on myosin II but not on actin dynamics.
    Nat Cell Biol. 2013 Jul;15(7):853-9 PMID: 23770677
  112. The septin cortex at the yeast mother-bud neck.
    Curr Opin Microbiol. 2001 Dec;4(6):681-9 PMID: 11731320
  113. The contractile ring. I. Fine structure of dividing mammalian (HeLa) cells and the effects of cytochalasin B.
    Z Zellforsch Mikrosk Anat. 1970;109(4):431-49 PMID: 5498229
  114. Dependence of Chs2 ER export on dephosphorylation by cytoplasmic Cdc14 ensures that septum formation follows mitosis.
    Mol Biol Cell. 2012 Jan;23(1):45-58 PMID: 22072794
  115. The Saccharomyces cerevisiae Mob2p-Cbk1p kinase complex promotes polarized growth and acts with the mitotic exit network to facilitate daughter cell-specific localization of Ace2p transcription factor.
    J Cell Biol. 2002 Sep 2;158(5):885-900 PMID: 12196508
  116. Counting cytokinesis proteins globally and locally in fission yeast.
    Science. 2005 Oct 14;310(5746):310-4 PMID: 16224022
  117. Isolation and partial purification of the Saccharomyces cerevisiae cytokinetic apparatus.
    Cytoskeleton (Hoboken). 2010 Jan;67(1):13-22 PMID: 19790107
  118. Stable and dynamic axes of polarity use distinct formin isoforms in budding yeast.
    Mol Biol Cell. 2004 Nov;15(11):4971-89 PMID: 15371545
  119. Spatial regulation of the exocyst complex by Rho1 GTPase.
    Nat Cell Biol. 2001 Apr;3(4):353-60 PMID: 11283608
  120. Septin filament formation is essential in budding yeast.
    Dev Cell. 2011 Apr 19;20(4):540-9 PMID: 21497764
  121. Phosphorylation-dependent regulation of septin dynamics during the cell cycle.
    Dev Cell. 2003 Mar;4(3):345-57 PMID: 12636916
  122. Yeast Cbk1 and Mob2 activate daughter-specific genetic programs to induce asymmetric cell fates.
    Cell. 2001 Dec 14;107(6):739-50 PMID: 11747810
  123. Mlc1p promotes septum closure during cytokinesis via the IQ motifs of the vesicle motor Myo2p.
    EMBO J. 2002 Dec 2;21(23 ):6397-408 PMID: 12456647
  124. Retention of Chs2p in the ER requires N-terminal CDK1-phosphorylation sites.
    Cell Cycle. 2009 Sep 15;8(18):2964-74 PMID: 19713768
  125. The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation.
    Mol Cell. 1998 Dec;2(6):709-18 PMID: 9885559
  126. Subunit-dependent modulation of septin assembly: budding yeast septin Shs1 promotes ring and gauze formation.
    J Cell Biol. 2011 Dec 12;195(6):993-1004 PMID: 22144691
  127. Cytokinesis in animal cells.
    Annu Rev Cell Dev Biol. 2012;28:29-58 PMID: 22804577
Article Info
Journal
Seminars in cell & developmental biology
Abbr.
Semin Cell Dev Biol
ISSN
1096-3634
DOI
10.1016/j.semcdb.2016.01.043
Email
[email protected]
[email protected]
Published
2016-00-00
Epub
2016-00-01
Pages
19-27
Language
English
Region
England
NLM ID
9607332
PMCID
PMC4884668
Subset
IM
Grants
Wellcome Trust · WT101885MA · United Kingdom
External Links
PubMed source DOI: 10.1016/j.semcdb.2016.01.043 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2