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PMID: 2870017 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The human tyrosine aminotransferase gene mapped to the long arm of chromosome 16 (region 16q22----q24) by somatic cell hybrid analysis and in situ hybridization.

Human genetics ·Vol. 72 ·No. 3 ·1986-03-00 ·Pages 221-4

Barton DE, Yang-Feng TL, Francke U

Abstract

Tyrosine aminotransferase (TAT; EC 2.6.1.5) is a liver enzyme involved in amino acid metabolism and gluconeogenesis. Low levels of TAT have been implicated in several inherited disorders, particularly tyrosinemia II (Richner-Hanhart syndrome). We have determined the chromosomal location of the human TAT gene by Southern blot hybridization analysis of DNAs from 18 human X rodent hybrid cell lines, using a rat cDNA probe. The results indicate that the TAT gene maps to chromosome 16. Analysis of two hybrids containing a rearranged chromosome 16 allowed assignment of the TAT locus to 16q22----24. In situ hybridization to human metaphase chromosomes confirmed this regional assignment.

MeSH Terms

Animals Chromosome Banding Chromosome Mapping Chromosomes, Human, 16-18 Cricetinae Cricetulus DNA/genetics DNA Restriction Enzymes Genetic Markers Humans Hybrid Cells Karyotyping Nucleic Acid Hybridization Rats Tyrosine Transaminase/genetics

Chemicals

Genetic Markers DNA Tyrosine Transaminase DNA Restriction Enzymes

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Barton D E

Yang-Feng T L

Francke U

References (21)

21 references, click to expand

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Article Info

Journal

Human genetics

Abbr.

Hum Genet

ISSN

0340-6717

DOI

10.1007/BF00291881

Published

1986-03-00

Pages

221-4

Language

English

Region

Germany

NLM ID

7613873

Subset

Grants

NIGMS NIH HHS · GM26105 · United States

NIGMS NIH HHS · T32GM07439 · United States

External Links

PubMed source DOI: 10.1007/BF00291881 View journal details

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The human tyrosine aminotransferase gene mapped to the long arm of chromosome 16 (region 16q22----q24) by somatic cell hybrid analysis and in situ hybridization.

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