The most common fragile site in man is 3p14.

Human genetics ·Vol. 72 ·No. 3 ·1986-03-00 ·Pages 215-20

Smeets DF, Scheres JM, Hustinx TW

Abstract

In man a common fragile site is known to occur at 3p14. We studied the expression of this fragility in a group of 70 normal healthy subjects. Chromosome breaks, chromatid breaks and gaps at 3p14 could be observed in every examined individual, and in a total of 7000 metaphases they were seen in a mean of 4% of cells. Fluorescence studies in ten persons with chromosome No. 3 polymorphism showed that in all cases both Nos. 3 were about equally liable to breakage. A considerable variation in the fra 3p14 expression was found between individuals as well as in repeated cultures from the same person. Neither sex nor age influences could be detected. Cultures with a high percentage of lesions at 3p14 tended to have also a high number of lesions at other sites. Methotrexate and fluorodeoxyuridine markedly enhanced the expression of fra 3p14 and other fragilities. It is concluded that the chromosomal region at 3p14 represents man's most common fragile site, the expression of which seems to be influenced by environmental and heritable factors.

MeSH Terms

Adolescent Adult Aged Child Child, Preschool Chromosome Aberrations/drug effects Chromosome Banding Chromosome Fragile Sites Chromosome Fragility Chromosomes, Human, 1-3 Female Floxuridine/pharmacology Humans Infant Karyotyping Male Methotrexate/pharmacology Middle Aged Pedigree

Chemicals

Floxuridine Methotrexate

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Smeets D F

Scheres J M

Hustinx T W

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31 references, click to expand

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Article Info

Journal

Human genetics

Abbr.

Hum Genet

ISSN

0340-6717

DOI

10.1007/BF00291880

Published

1986-03-00

Pages

215-20

Language

English

Region

Germany

NLM ID

7613873

Subset

External Links

PubMed source DOI: 10.1007/BF00291880 View journal details

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The most common fragile site in man is 3p14.

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