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PMID: 2983097 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Nucleotide sequence of avian sarcoma virus UR2 and comparison of its transforming gene with other members of the tyrosine protein kinase oncogene family.

Journal of virology ·Vol. 53 ·No. 3 ·1985-03-00 ·Pages 879-84

Neckameyer WS, Wang LH

Abstract

The genome of avian sarcoma virus UR2 was completely sequenced and found to have a size of 3,165 nucleotides. The UR2-specific transforming sequence, ros, with a length of 1,273 nucleotides, is inserted between the truncated gag gene coding for p19 and the env gene coding for gp37 of the UR2AV helper virus. The deduced amino acid sequence for the UR2 transforming protein P68 gives a molecular weight of 61,113 and shows that it is closely related to the oncogene family coding for tyrosine protein kinases. P68 contains two distinctive hydrophobic regions that are absent in other tyrosine kinases, and it has unique amino acid changes and insertions within the conserved domain of the kinases. These characteristics may modulate the activity and target specificity of P68.

MeSH Terms
Amino Acid Sequence Amino Acids/analysis Avian Sarcoma Viruses/genetics Base Sequence DNA, Viral/analysis Genes, Viral Molecular Weight Oncogenes Protein Kinases/analysis Protein-Tyrosine Kinases
Chemicals
Amino Acids DNA, Viral Protein Kinases Protein-Tyrosine Kinases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Neckameyer W S
Wang L H
References (31)
31 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.53.3.879-884.1985
Published
1985-03-00
Pages
879-84
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC254722
Subset
IM
Grants
NCI NIH HHS · CA00574 · United States
NCI NIH HHS · CA29339 · United States
PHS HHS · T32A107233 · United States
Databases
GENBANK
M10455
External Links
PubMed source DOI: 10.1128/JVI.53.3.879-884.1985 PMC Full Text View journal details
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