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PMID: 2993660 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Virion component of herpes simplex virus type 1 KOS interferes with early shutoff of host protein synthesis induced by herpes simplex virus type 2 186.

Journal of virology ·Vol. 56 ·No. 1 ·1985-10-00 ·Pages 312-6

Hill TM, Sadler JR, Betz JL

Abstract

Herpes simplex virus (HSV) strains HSV type 1 (HSV-1) KOS and HSV-2 186 are representative of delayed and early shutoff strains, respectively, with regard to their ability to inhibit protein synthesis in Friend erythroleukemia cells. When these cells were simultaneously infected with HSV-1 KOS and HSV-2 186, HSV-1 KOS interfered with the rapid suppression of globin synthesis induced by HSV-2 186. The observed interference was competitive and not due to exclusion of HSV-2 by HSV-1 at the level of adsorption. Furthermore, UV-irradiated HSV-1 KOS was also effective at interfering with the early shutoff function of HSV-2 186, indicating that a virion component is responsible for the observed interference.

MeSH Terms
Animals Cell Line Gene Expression Regulation Globins/biosynthesis Leukemia, Erythroblastic, Acute Mice Protein Biosynthesis Simplexvirus/genetics Species Specificity Virion/genetics
Chemicals
Globins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hill T M
Sadler J R
Betz J L
References (31)
31 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.56.1.312-316.1985
Published
1985-10-00
Pages
312-6
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC252537
Subset
IM
Grants
NIAID NIH HHS · AI 07209 · United States
NIAID NIH HHS · AI 14592 · United States
NIGMS NIH HHS · GM 30709 · United States
External Links
PubMed source DOI: 10.1128/JVI.56.1.312-316.1985 PMC Full Text View journal details
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