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PMID: 3008153 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Transforming activity of human papillomavirus type 16 DNA sequence in a cervical cancer.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 83 ·No. 7 ·1986-04-00 ·Pages 2200-3

Tsunokawa Y, Takebe N, Kasamatsu T, Terada M, Sugimura T

Abstract

A genomic DNA sample from cervical cancer tissue, containing human papillomavirus (HPV) type 16, was found to induce malignant transformation of NIH 3T3 cells when it was tested by transfection assays using the calcium phosphate coprecipitation technique. The primary and secondary transformants contained the HPV type 16 DNA sequences and human specific Alu family sequences. To the best of our knowledge, it has not been reported previously that HPV type 16 DNA sequences in total genomic DNA from a cervical cancer have transforming activity.

MeSH Terms
Adenocarcinoma/genetics,microbiology Animals Cell Line Cell Transformation, Viral DNA, Neoplasm/genetics DNA, Viral/genetics Female Humans Mice Papillomaviridae/genetics Repetitive Sequences, Nucleic Acid Uterine Cervical Neoplasms/genetics,microbiology
Chemicals
DNA, Neoplasm DNA, Viral
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Tsunokawa Y
Takebe N
Kasamatsu T
Terada M
Sugimura T
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27 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.83.7.2200
Published
1986-04-00
Pages
2200-3
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC323259
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.83.7.2200 PMC Full Text View journal details
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