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PMID: 3043188 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

B-raf, a new member of the raf family, is activated by DNA rearrangement.

Molecular and cellular biology ·Vol. 8 ·No. 6 ·1988-06-00 ·Pages 2651-4

Ikawa S, Fukui M, Ueyama Y, Tamaoki N, Yamamoto T, Toyoshima K

Abstract

Complementary DNA clones of a putative transforming gene were isolated from NIH 3T3 cells transformed with human Ewing sarcoma DNA. The gene was termed B-raf because it is related to but distinct from c-raf and A-raf. It appears that substitution in the amino-terminal portion of the normal B-raf protein confers transforming activity to the gene.

MeSH Terms

Base Sequence Cell Line, Transformed Cloning, Molecular DNA/analysis,metabolism Gene Expression Regulation Humans Molecular Sequence Data Protein Kinases/genetics Proto-Oncogene Proteins/analysis,genetics Proto-Oncogene Proteins c-raf Sarcoma, Ewing/analysis

Chemicals

Proto-Oncogene Proteins DNA Protein Kinases Proto-Oncogene Proteins c-raf

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Ikawa S

Department of Oncology, University of Tokyo, Japan.

Fukui M

Ueyama Y

Tamaoki N

Yamamoto T

Toyoshima K

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Article Info

Journal

Molecular and cellular biology

Abbr.

Mol Cell Biol

ISSN

0270-7306

DOI

10.1128/mcb.8.6.2651-2654.1988

Published

1988-06-00

Pages

2651-4

Language

English

Region

United States

NLM ID

8109087

PMCID

PMC363468

Subset

Databases

GENBANK

M21001

External Links

PubMed source DOI: 10.1128/mcb.8.6.2651-2654.1988 PMC Full Text View journal details

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B-raf, a new member of the raf family, is activated by DNA rearrangement.

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