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PMID: 3048355 Published · ppublish English Journal Article Review

Recessive mechanisms of malignancy.

British journal of cancer ·Vol. 58 ·No. 2 ·1988-08-00 ·Pages 115-21

Green AR

Abstract

It is increasingly recognised that recessive mutations play an important role in the pathogenesis of many forms of malignancy. Some of the affected loci may prove to be recessively-activated proto-oncogenes, but others are now known to be tumorigenic solely by virtue of their loss or inactivation and therefore form a distinct and novel family of tumour genes. Preliminary evidence suggests that such genes are likely to be functionally heterogeneous and to encode molecules involved in the inhibition of cellular proliferation and/or the induction of differentiation. Their further study is likely to illuminate fundamental mechanisms of normal cellular growth and differentiation as well as having important implications for the pathogenesis and management of cancer.

MeSH Terms
Animals Genes, Recessive Humans Mice Neoplasms/genetics Rats
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Green A R
Imperial Cancer Research Fund Laboratories, St Bartholomew's Hospital, London, UK.
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Article Info
Journal
British journal of cancer
Abbr.
Br J Cancer
ISSN
0007-0920
DOI
10.1038/bjc.1988.176
Published
1988-08-00
Pages
115-21
Language
English
Region
England
NLM ID
0370635
PMCID
PMC2246761
Subset
IM
External Links
PubMed source DOI: 10.1038/bjc.1988.176 PMC Full Text View journal details
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