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PMID: 30786245 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Abnormal Sleep Spindles, Memory Consolidation, and Schizophrenia.

Annual review of clinical psychology ·Vol. 15 ·2019-00-07 ·Pages 451-479

Manoach DS, Stickgold R

Abstract

There is overwhelming evidence that sleep is crucial for memory consolidation. Patients with schizophrenia and their unaffected relatives have a specific deficit in sleep spindles, a defining oscillation of non-rapid eye movement (NREM) Stage 2 sleep that, in coordination with other NREM oscillations, mediate memory consolidation. In schizophrenia, the spindle deficit correlates with impaired sleep-dependent memory consolidation, positive symptoms, and abnormal thalamocortical connectivity. These relations point to dysfunction of the thalamic reticular nucleus (TRN), which generates spindles, gates the relay of sensory information to the cortex, and modulates thalamocortical communication. Genetic studies are beginning to provide clues to possible neurodevelopmental origins of TRN-mediated thalamocortical circuit dysfunction and to identify novel targets for treating the related memory deficits and symptoms. By forging empirical links in causal chains from risk genes to thalamocortical circuit dysfunction, spindle deficits, memory impairment, symptoms, and diagnosis, future research can advance our mechanistic understanding, treatment, and prevention of schizophrenia.

Keywords
cognition endophenotype genetics memory schizophrenia sleep spindles
MeSH Terms
Brain Waves/physiology Cerebral Cortex/physiopathology Humans Memory Consolidation/physiology Nerve Net/physiopathology Schizophrenia/physiopathology Sleep Stages/physiology Thalamic Nuclei/physiopathology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Manoach Dara S
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA; email: [email protected]. | Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA.
Stickgold Robert
Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215; email: [email protected].
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Article Info
Journal
Annual review of clinical psychology
Abbr.
Annu Rev Clin Psychol
ISSN
1548-5951
DOI
10.1146/annurev-clinpsy-050718-095754
Email
[email protected]
[email protected]
Published
2019-00-07
Epub
2019-00-20
Pages
451-479
Language
English
Region
United States
NLM ID
101235325
PMCID
PMC7307009
Subset
IM
Grants
NIMH NIH HHS · K24 MH099421 · United States
NIMH NIH HHS · R01 MH048832 · United States
NIMH NIH HHS · R01 MH092638 · United States
NIMH NIH HHS · R01 MH107579 · United States
External Links
PubMed source DOI: 10.1146/annurev-clinpsy-050718-095754 PMC Full Text View journal details
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