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PMID: 3086846 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Palindromic sequences are associated with sites of DNA breakage during gene conversion.

Nucleic acids research ·Vol. 14 ·No. 9 ·1986-05-12 ·Pages 3871-82

Krawinkel U, Zoebelein G, Bothwell AL

Abstract

Gene conversion is a recombinatorial mechanism which transfers genetic information from a donor into a recipient gene. A case of gene conversion between immunoglobulin VH region genes was analysed and palindromic sequences were found to be located near to the left recombinatorial breakpoint, which also is flanked by a direct repeat sequence. We performed a computer search for palindromes and direct repeats in the published sequences of eucaryotic genes which had been involved in gene conversion. In these sequences, the palindrome with the best or second best quality is located near to a breakpoint of recombination. A correlation of recombination breakpoints with direct repeats was not observed. This suggests that gene conversion is promoted by palindromic sequences.

MeSH Terms
Animals Base Sequence Gene Conversion Immunoglobulin Heavy Chains/genetics Immunoglobulin Variable Region/genetics Mice Nucleic Acid Conformation Recombination, Genetic Repetitive Sequences, Nucleic Acid
Chemicals
Immunoglobulin Heavy Chains Immunoglobulin Variable Region
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Krawinkel U
Zoebelein G
Bothwell A L
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29 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/14.9.3871
Published
1986-05-12
Pages
3871-82
Language
English
Region
England
NLM ID
0411011
PMCID
PMC339821
Subset
IM
Databases
GENBANK
X03850, X04369
External Links
PubMed source DOI: 10.1093/nar/14.9.3871 PMC Full Text View journal details
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