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PMID: 3111975 Published · ppublish English Journal Article

The gene coding for the human T-lymphocyte CD2 antigen is located on chromosome 1p.

Human genetics ·Vol. 76 ·No. 2 ·1987-06-00 ·Pages 191-5

Brown MH, Gorman PA, Sewell WA, Spurr NK, Sheer D, Crumpton MJ

Abstract

A cDNA clone encoding the human T lymphocyte sheep erythrocyte receptor [the CD2 (T11) antigen] was used as a probe to define the chromosomal location of the gene. The signal, revealed by hybridisation to Southern blots of genomic DNA from somatic cell hybrids, showed a high degree of concordance for human chromosome 1. In particular, the hybrid F4Sc13C19 which contained the short arm only of human chromosome 1 was positive. The location of the CD2 gene to 1p13 was confirmed by in situ hybridisation.

MeSH Terms
Animals Antigens, Differentiation, T-Lymphocyte Antigens, Surface/genetics Chromosome Banding Chromosome Mapping Chromosomes, Human, Pair 1 DNA/genetics Humans Hybrid Cells Karyotyping Mice Nucleic Acid Hybridization Rats T-Lymphocytes/immunology
Chemicals
Antigens, Differentiation, T-Lymphocyte Antigens, Surface DNA
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Brown M H
Gorman P A
Sewell W A
Spurr N K
Sheer D
Crumpton M J
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00284920
Published
1987-06-00
Pages
191-5
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
Grants
Cancer Research UK · A3585 · United Kingdom
External Links
PubMed source DOI: 10.1007/BF00284920 View journal details
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