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PMID: 3145816 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The MAL63 gene of Saccharomyces encodes a cysteine-zinc finger protein.

Current genetics ·Vol. 14 ·No. 4 ·1988-10-00 ·Pages 319-23

Kim J, Michels CA

Abstract

Inducible maltose fermentation by Saccharomyces carlesbergensis requires the product of the MAL63 gene of the MAL6 locus. It has been suggested that this gene product is an activator protein controlling the expression of the structural genes encoding the maltose fermentative enzymes perhaps by binding to DNA sequences upstream of these genes. We report the sequence of the MAL63 gene. A single open reading frame is seen capable of encoding a protein of 470 amino acid residues. The deduced sequence of this protein indicates that it is a cysteine-zinc finger protein supporting the hypothesis that the MAL63 gene product is a DNA binding protein.

MeSH Terms
Amino Acid Sequence Base Sequence Binding Sites Chelating Agents Cysteine/genetics,physiology DNA-Binding Proteins/genetics,metabolism Fungal Proteins/genetics,metabolism Gene Expression Regulation Genes, Fungal Maltose/genetics Metalloproteins/genetics,metabolism Molecular Sequence Data Saccharomyces/genetics Zinc/metabolism
Chemicals
Chelating Agents DNA-Binding Proteins Fungal Proteins Metalloproteins Maltose Zinc Cysteine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kim J
Department of Biology, Queens College, Flushing, NY.
Michels C A
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36 references, click to expand
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Article Info
Journal
Current genetics
Abbr.
Curr Genet
ISSN
0172-8083
DOI
10.1007/BF00419988
Published
1988-10-00
Pages
319-23
Language
English
Region
United States
NLM ID
8004904
Subset
IM
Grants
NIGMS NIH HHS · GM28216 · United States
External Links
PubMed source DOI: 10.1007/BF00419988 View journal details
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