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PMID: 32119 Published · ppublish English Journal Article Review

The incretin concept today.

Diabetologia ·Vol. 16 ·No. 2 ·1979-02-00 ·Pages 75-85

Creutzfeldt W

Abstract

1. The insulinogenic factor of the gastrointestinal mucosa named "incretin" is only one part of the complex enteroinsular axis. --2. Of the chemically defined gastrointestinal hormones GIP is the strongest incretin candidate. --3. Because of the dual function of GIP as gastrone and insulinotropic substance several safeguards against GIP-mediated insulin hypoglycaemia exist. --4. No pathological condition has yet been found which is causally related to hyper- or hyposecretion of GIP. However, an exaggerated GIP response (usually secondary to the disease) may participate in the pathogenesis of hyperinsulinaemia of patients with obesity and duodenal ulcer. --5. The injection of GIP antibodies only partially abolishes the incretin effect. Therefore, GIP, although important, is not the only incretin.

MeSH Terms
Absorption Diabetes Mellitus/metabolism Feedback Gastrins/physiology Gastrointestinal Hormones/physiology Humans Insulin/metabolism Insulin Secretion Neurotransmitter Agents Obesity/metabolism Peptides Vagus Nerve/physiology
Chemicals
Gastrins Gastrointestinal Hormones Insulin Neurotransmitter Agents Peptides
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Creutzfeldt W
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55 references, click to expand
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Article Info
Journal
Diabetologia
Abbr.
Diabetologia
ISSN
0012-186X
DOI
10.1007/BF01225454
Published
1979-02-00
Pages
75-85
Language
English
Region
Germany
NLM ID
0006777
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01225454 View journal details
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