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PMID: 3462067 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Radioimmunoassay typing gives a more precise definition of the HLA association of type 1 (insulin-dependent) diabetes.

Diabetologia ·Vol. 29 ·No. 7 ·1986-07-00 ·Pages 430-3

Tosi R, Vela M, Adorno D, Longo A, Papola F, Maccarone D, Centis D, Tanigaki N, Raponi MP, Candela A

Abstract

The problem of the HLA association of Type 1 (insulin-dependent) diabetes was re-examined by testing Class II antigenic specificities detectable by radioimmunoassay. Established (DRw53, DQw1, DQw2, DQw3) as well as newly described (DC5, DCalpha3) specificities were typed. The data obtained suggest that the association with DR3 and DR4 is secondary to that with DQ specificities in linkage disequilibrium with DR3 and DR4.

MeSH Terms
Diabetes Mellitus, Type 1/genetics,immunology Female Genotype HLA-DR Antigens Histocompatibility Antigens Class II/analysis,genetics Humans Male Polymorphism, Genetic Radioimmunoassay
Chemicals
HLA-DR Antigens Histocompatibility Antigens Class II
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Tosi R
Vela M
Adorno D
Longo A
Papola F
Maccarone D
Centis D
Tanigaki N
Raponi M P
Candela A
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22 references, click to expand
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Article Info
Journal
Diabetologia
Abbr.
Diabetologia
ISSN
0012-186X
DOI
10.1007/BF00506534
Published
1986-07-00
Pages
430-3
Language
English
Region
Germany
NLM ID
0006777
Subset
IM
Grants
NIAID NIH HHS · AI-20251 · United States
External Links
PubMed source DOI: 10.1007/BF00506534 View journal details
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