Home LiteratureArticle Details
PMID: 368577 Published · ppublish English Journal Article

The regulation of urea amidolyase of Saccharomyces cerevisiae: mating type influence on a constitutivity mutation acting in cis.

Molecular & general genetics : MGG ·Vol. 166 ·No. 3 ·1978-11-09 ·Pages 251-8

Lemoine Y, Dubois E, Wiame JM

Abstract

Constitutivity for the synthesis of the urea amidolyase bienzymatic complex is obtained by durOh mutations located in the regulatory genetic region adjacent to the dur1, dur2 gene cluster. The durOh mutations act only in cis and are a new case of cis effect strongly cancelled in alpha/a diploid, similar to cargA+Oh mutation shown previously to lead to arginase constitutivity. Illegitimate diploids do not show such a cancellation of constitutivity. The constitutivity produced by durOh mutation comprises the process of induction and the release of the glutamine effect. It does not impair the NH+4 effect.

MeSH Terms
Allophanate Hydrolase/genetics Amidohydrolases/genetics Carbon-Nitrogen Ligases Chromosome Mapping Diploidy Genes, Dominant Genes, Recessive Genes, Regulator Ligases/genetics Multienzyme Complexes/genetics Mutation Phenotype Saccharomyces cerevisiae/genetics Urea/metabolism
Chemicals
Multienzyme Complexes Urea Amidohydrolases Allophanate Hydrolase Ligases Carbon-Nitrogen Ligases urea carboxylase (hydrolyzing)
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Lemoine Y
Dubois E
Wiame J M
References (24)
24 references, click to expand
  1. Purification and properties of the urea amidolyase from Candida utilis.
    J Biol Chem. 1977 Mar 10;252(5):1628-32 PMID: 14157
  2. The induction of urea carboxylase and allophanate hydrolase in Saccharomyces cerevisiae.
    J Biol Chem. 1973 Sep 10;248(17):6203-9 PMID: 4580053
  3. Release of the "ammonia effect" on three catabolic enzymes by NADP-specific glutamate dehydrogenaseless mutations in Saccharomyces cerevisiae.
    Biochem Biophys Res Commun. 1973 Feb 20;50(4):967-72 PMID: 4144122
  4. Cis-dominant regulatory mutations affecting the formation of glucose-repressible alcohol dehydrogenase (ADHII) in Saccharomyces cerevisiae.
    Mol Gen Genet. 1976 Jun 15;145(3):327-33 PMID: 781520
  5. An adenosine triphosphate-dependent, avidin-sensitive enzymatic cleavage of urea in yeast and green algae.
    J Biol Chem. 1968 Oct 10;243(19):5213-5 PMID: 5679987
  6. Characterization of a dominant, constitutive mutation, PHOO, for the repressible acid phosphatase synthesis in Saccharomyces cerevisiae.
    J Bacteriol. 1974 Nov;120(2):608-17 PMID: 4616940
  7. Clustering of the genes for allantoin degradation in Saccharomyces cerevisiae.
    J Bacteriol. 1974 Aug;119(2):461-8 PMID: 4604238
  8. Urea amidolyase of Candida utilis. Characterization of the urea cleavage reactions.
    Biochim Biophys Acta. 1976 Jul 8;438(2):574-83 PMID: 8111
  9. Regulation of genes controlling synthesis of the galactose pathway enzymes in yeast.
    Genetics. 1966 Sep;54(3):911-6 PMID: 5970626
  10. Urea carboxylase and allophanate hydrolase. Two components of adenosine triphosphate:urea amido-lyase in Saccharomyces cerevisiae.
    J Biol Chem. 1972 Mar 10;247(5):1349-53 PMID: 4551940
  11. Urea transport in Saccharomyces cerevisiae.
    J Bacteriol. 1975 Feb;121(2):571-6 PMID: 1089637
  12. Oxaluric acid: a non-metabolizable inducer of the allantoin degradative enzymes in Saccharomyces cerevisiae.
    J Bacteriol. 1974 Mar;117(3):1240-7 PMID: 4591950
  13. Tetraploid Saccharomyces.
    J Gen Microbiol. 1951 Nov;5(5 Suppl.):885-93 PMID: 14908026
  14. Glutamine and ammonia in nitrogen catabolite repression of Saccharomyces cerevisiae.
    Biochem Biophys Res Commun. 1977 Mar 21;75(2):233-9 PMID: 322661
  15. Absence of involvement of glutamine synthetase and of NAD-linked glutamate dehydrogenase in the nitrogen catabolite repression of arginase and other enzymes in Saccharomyces cerevisiae.
    Biochem Biophys Res Commun. 1974 Sep 9;60(1):150-7 PMID: 4153896
  16. Induction of the allantoin degradative enzymes in Saccharomyces cerevisiae by the last intermediate of the pathway.
    Proc Natl Acad Sci U S A. 1973 Aug;70(8):2340-4 PMID: 4599622
  17. Specific induction of catabolism and its relation to repression of biosynthesis in arginine metabolism of Saccharomyces cerevisiae.
    J Mol Biol. 1978 Jul 15;122(4):383-406 PMID: 357733
  18. Regulation of the carbamoylphosphate synthetase belonging to the arginine biosynthetic pathway of Saccharomyces cerevisiae.
    J Mol Biol. 1972 Jun 20;67(2):277-87 PMID: 4557204
  19. A gene cluster in Aspergillus nidulans with an internally located cis-acting regulatory region.
    Nature. 1975 Mar 6;254(5495):26-31 PMID: 1089903
  20. Chromosome mapping of the CYC7 gene determining yeast iso-2-cytochrome c: structural and regulatory regions.
    Proc Natl Acad Sci U S A. 1978 Mar;75(3):1437-41 PMID: 206899
  21. Protein measurement with the Folin phenol reagent.
    J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
  22. Regulation of arginine biosynthesis in Saccharomyces cerevisiae: isolation of a cis-dominant, constitutive mutant for ornithine carbamoyltransferase synthesis.
    J Bacteriol. 1976 Oct;128(1):49-55 PMID: 789352
  23. Urea carboxylase and allophanate hydrolase: two components of a multienzyme complex in Saccharomyces cerevisiae.
    Biochem Biophys Res Commun. 1972 Oct 6;49(1):45-51 PMID: 4562164
  24. Mating-type effect on cis mutations leading to constitutivity of ornithine transaminase in diploid cells of Saccharomyces cerevisiae.
    Genetics. 1979 Jul;92(3):749-58 PMID: 395019
Article Info
Journal
Molecular & general genetics : MGG
Abbr.
Mol Gen Genet
ISSN
0026-8925
Published
1978-11-09
Pages
251-8
Language
English
Region
Germany
NLM ID
0125036
Subset
IM
External Links
PubMed source
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2