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PMID: 3905095 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Cationised IgM rheumatoid factor: in-vivo glomerular localization and immunoabsorptive capacity in the mouse.

Clinical and experimental immunology ·Vol. 62 ·No. 1 ·1985-10-00 ·Pages 150-8

Ford PM, Kosatka I

Abstract

This paper reports the results of in-vivo studies on the binding of intravenously injected cationised human IgM rheumatoid factor to glomeruli in mice. Evidence is presented to show that glomerular bound cationised IgM rheumatoid factor can act as an immunoabsorbent binding both endogenous immunoglobulin containing material from the circulation as well as intravenously injected immunoglobulins either in the form of aggregates or immune complexes.

MeSH Terms
Animals Antigen-Antibody Complex/metabolism Cations/metabolism Fluorescent Antibody Technique Immunoglobulin G/metabolism Immunoglobulin M/metabolism Kidney Glomerulus/immunology,metabolism Mice Mice, Inbred CBA Rheumatoid Factor/metabolism Serum Albumin, Bovine/immunology
Chemicals
Antigen-Antibody Complex Cations Immunoglobulin G Immunoglobulin M Serum Albumin, Bovine Rheumatoid Factor
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ford P M
Kosatka I
References (28)
28 references, click to expand
  1. Passive serum sickness in the mouse: effect of interstrain differences on glomerular deposition of immune complexes.
    Br J Exp Pathol. 1975 Jun;56(3):199-204 PMID: 1191515
  2. Immunological detection of proteins after isoelectric focusing in thin layer agarose gel: a specific application for the characterization of immunoglobulin diversity.
    J Clin Lab Immunol. 1983 Apr;10(4):225-8 PMID: 6191034
  3. Acute poststreptococcal glomerulonephritis in Maracaibo. II: Studies on the incidence, nature, and significance of circulating anti-immunoglobulins.
    Ann Rheum Dis. 1979 Jun;38(3):257-61 PMID: 314784
  4. In situ immune complex formation in the mouse glomerulus: reactivity with human IgM rheumatoid factor and the effect on subsequent immune complex deposition.
    Clin Exp Immunol. 1983 Feb;51(2):285-91 PMID: 6340871
  5. Glomerular localization of circulating antiglobulin activity in essential mixed cryoglobulinemia with glomerulonephritis.
    Kidney Int. 1982 Feb;21(2):387-94 PMID: 6978427
  6. Renal pathology of Waldenström's macroglobulinaemia with monoclonal antiglomerular antibodies and nephrotic syndrome.
    Clin Exp Immunol. 1980 Aug;41(2):196-204 PMID: 6777101
  7. Renal localization of antiglobulins in glomerulonephritis and after renal transplantation.
    Arthritis Rheum. 1977 May;20(4):947-61 PMID: 324484
  8. The effect of human IgM rheumatoid factor on renal glomerular immune complex deposition in passive serum sickness in the mouse.
    Immunology. 1982 Aug;46(4):761-8 PMID: 6213554
  9. Experimental glomerulonephritis. The pathogenesis of a laboratory model resembling the spectrum of human glomerulonephritis.
    J Exp Med. 1961 May 1;113:899-920 PMID: 13723140
  10. Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens. V. Fixed glomerular antigens in the pathogenesis of heterologous immune complex glomerulonephritis.
    Lab Invest. 1978 Apr;38(4):502-10 PMID: 147961
  11. Effect of cationized antibodies in performed immune complexes on deposition and persistence in renal glomeruli.
    J Exp Med. 1982 Sep 1;156(3):766-77 PMID: 7108443
  12. In situ immune complex formation and glomerular injury.
    Kidney Int. 1980 Jan;17(1):1-13 PMID: 6990087
  13. Size and charge selective permeability defects induced in glomerular basement membrane by a polycation.
    Kidney Int. 1984 Jan;25(1):11-9 PMID: 6727123
  14. Experimental glomerulonephritis in the isolated perfused rat kidney.
    J Clin Invest. 1978 Dec;62(6):1275-87 PMID: 372233
  15. Quantitative studies of in situ immune complex glomerulonephritis in the rat induced by planted, cationized antigen.
    J Exp Med. 1982 Feb 1;155(2):460-74 PMID: 6460074
  16. In situ formation of subepithelial immune complexes in the rabbit glomerulus: requirement of a cationic antigen.
    Nephron. 1984;36(4):257-64 PMID: 6369163
  17. Dependence of the chemical nature of antibodies on the net electrical charge of antigens.
    Proc Natl Acad Sci U S A. 1966 Feb;55(2):445-52 PMID: 4161286
  18. Restricted subpopulations of DNA antibodies in kidneys of mice with systemic lupus. Comparison of antibodies in serum and renal eluates.
    Arthritis Rheum. 1980 Apr;23(4):392-403 PMID: 7370058
  19. Pathology of the kidney in Waldenström's macroglobulinemia. Study of sixteen cases.
    N Engl J Med. 1970 Jul 16;283(3):123-9 PMID: 4987279
  20. Covalent attachment of soluble proteins by nonenzymatically glycosylated collagen. Role in the in situ formation of immune complexes.
    J Exp Med. 1983 Nov 1;158(5):1739-44 PMID: 6415211
  21. Immunopathology of renal extracellular membranes in diabetes mellitus. Specificity of tubular basement-membrane immunofluorescence.
    Diabetes. 1976 Aug;25(8):701-8 PMID: 782982
  22. Interaction of rheumatoid factor with immune complexes in experimental glomerulonephritis--possible role of antiglobulins in chronicity.
    J Rheumatol Suppl. 1983 Dec;11:81-4 PMID: 6230448
  23. Agarose isoelectric focusing of native human immunoglobulin M and alpha 2-macroglobulin.
    J Immunol Methods. 1979;28(1-2):1-11 PMID: 89171
  24. In situ formation of antigen-antibody complexes in the mouse glomerulus.
    Immunology. 1979 Nov;38(3):473-9 PMID: 391695
  25. Studies of the reticuloendothelial system (RES). I. Measurement of the phagocytic capacity of the RES in man and dog.
    J Clin Invest. 1963 Mar;42:417-26 PMID: 13956267
  26. Comparison of the inactivation of IgM and IgG complement fixation sites by acid and base.
    J Immunol. 1976 Oct;117(4):1387-91 PMID: 10334
  27. Charge of circulating immune complexes as a factor in glomerular basement membrane localization in mice.
    J Clin Invest. 1981 May;67(5):1305-13 PMID: 6453132
  28. Complement fixation by rheumatoid factor.
    J Clin Invest. 1975 Mar;55(3):437-45 PMID: 1078825
Article Info
Journal
Clinical and experimental immunology
Abbr.
Clin Exp Immunol
ISSN
0009-9104
Published
1985-10-00
Pages
150-8
Language
English
Region
England
NLM ID
0057202
PMCID
PMC1577397
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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