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PMID: 3920660 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Possible involvement of human D minigenes in the first complementarity-determining region of kappa light chains.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 82 ·No. 7 ·1985-04-00 ·Pages 2125-7

Chen PP, Kabat EA, Wu TT, Fong S, Carson DA

Abstract

The nucleotide sequences of the complementary strands of two human diversity region (D) minigenes, D2 and D4, show stretches of homology with two human variable region kappa chain (V kappa) genes, NG9 and HK101, respectively, in the first complementarity-determining region. In one V kappa sequence, the homology includes the 5' flanking region of D minigenes, which may comprise a recombinase recognition signal. It is thus conceivable that gene conversions involving D minigenes may contribute to V kappa diversity.

MeSH Terms
Antibody Diversity Base Sequence Genes Genetic Complementation Test Humans Immunoglobulin Light Chains/genetics Immunoglobulin Variable Region/genetics Immunoglobulin kappa-Chains/genetics
Chemicals
Immunoglobulin Light Chains Immunoglobulin Variable Region Immunoglobulin kappa-Chains
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Chen P P
Kabat E A
Wu T T
Fong S
Carson D A
References (45)
45 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.82.7.2125
Published
1985-04-00
Pages
2125-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC397505
Subset
IM
Grants
NIA NIH HHS · AG 04100 · United States
NIADDK NIH HHS · AM 25443 · United States
NCI NIH HHS · CA 13696 · United States
External Links
PubMed source DOI: 10.1073/pnas.82.7.2125 PMC Full Text View journal details
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