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PMID: 3935311 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Carbohydrate structure in tumor immunity.

Cancer metastasis reviews ·Vol. 4 ·No. 3 ·1985-00-00 ·Pages 221-60

Reading CL, Hutchins JT

Abstract

Researchers have endeavored to define surface alterations associated with neoplasia for at least 25 years. In comparisons of normal tissues with animal and human tumors, cultured cells before and after transformation with oncogenic agents, tumorigenic and nontumorigenic transformed cells, metastatic and nonmetastatic tumor cells, high- and low-metastatic variants, and tumor cells before and after induction of differentiation to a less malignant phenotype, a consistent finding has been some form of alteration in surface carbohydrate structures. These changes in glycolipids, glycoproteins and glycosaminoglycans are reviewed, and their structures are illustrated. Both nucleotide sugar biosynthesis and glycosyltransferase changes have been associated with these alterations. In some cases, alterations in transformed cells were related to growth, rather than transformation. In others, the altered glycoconjugates are truly tumor-associated. There is evidence that cell surface glycoconjugates may function in growth control. Altered carbohydrate structures could also serve as receptors for growth promoting factors and be directly responsible for altered growth control. Recent studies with monoclonal antibodies indicate that the vast majority of antibodies recognizing tumor-associated antigens are detecting altered carbohydrate structures. Mechanisms by which the immune system can recognize these carbohydrate structures are considered, and immune recognition of tumor-associated carbohydrate structural alterations is explored. A number of these hypotheses relating to alterations in glycosylation, growth control, and tumor immunity deserve further investigation.

MeSH Terms
Animals Antibodies/immunology Antigens, Neoplasm/analysis Carbohydrate Metabolism Carbohydrates/analysis,immunology Carrier Proteins/analysis Cell Differentiation Cell Line Complement System Proteins/immunology Cricetinae Galactosyltransferases/analysis Glycolipids/analysis Glycoproteins/analysis Glycosaminoglycans/analysis Humans Killer Cells, Natural/immunology Mice Neoplasms/analysis,immunology Nucleotides/biosynthesis Rats
Chemicals
Antibodies Antigens, Neoplasm Carbohydrates Carrier Proteins Glycolipids Glycoproteins Glycosaminoglycans Nucleotides Complement System Proteins Galactosyltransferases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Reading C L
Hutchins J T
References (313)
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Article Info
Journal
Cancer metastasis reviews
Abbr.
Cancer Metastasis Rev
ISSN
0167-7659
DOI
10.1007/BF00048097
Published
1985-00-00
Pages
221-60
Language
English
Region
Netherlands
NLM ID
8605731
Subset
IM
Grants
NCI NIH HHS · CA-23077 · United States
External Links
PubMed source DOI: 10.1007/BF00048097 View journal details
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