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PMID: 394876 Published · ppublish English Clinical Trial Journal Article Review

Retinoids and cancer.

Cancer chemotherapy and pharmacology ·Vol. 3 ·No. 4 ·1979-00-00 ·Pages 207-15

Bollag W

Abstract

The early and recent investigations in the field of retinoids and cancer are reviewed. The retinoids, including natural vitamin A compounds and their synthetic analogs, present a new class of substances exerting a prophylactic and a therapeutic effect both in certain experimental tumor models and in certain clinical conditions of preneoplastic and neoplastic lesions. Because of a particular physiological mechanism of action, the retinoids offer a new approach to the cancer problem, which is different from those of surgery, X-ray therapy, conventional chemotherapy, and immunotherapy.

MeSH Terms
Animals Cell Division/drug effects Cell Transformation, Neoplastic/drug effects Clinical Trials as Topic Humans Neoplasms/drug therapy,prevention & control Neoplasms, Experimental/drug therapy Tretinoin/therapeutic use Vitamin A/analogs & derivatives,pharmacology,physiology,therapeutic use
Chemicals
Vitamin A Tretinoin
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Bollag W
References (83)
83 references, click to expand
  1. [Vitamin A acid in the treatment of tumors. Studies on the effect of vitamin A acid on tumors in animal experiments].
    Schweiz Med Wochenschr. 1971 Jan 9;101(1):11-7 PMID: 5545412
  2. TISSUE CHANGES FOLLOWING DEPRIVATION OF FAT-SOLUBLE A VITAMIN.
    J Exp Med. 1925 Nov 30;42(6):753-77 PMID: 19869087
  3. The induction of differentiation in teratocarcinoma stem cells by retinoic acid.
    Cell. 1978 Oct;15(2):393-403 PMID: 214238
  4. A fine structural study on the therapeutic effect on an aromatic retinoid on chemically-induced skin papillomas of the mouse.
    Eur J Cancer. 1977 Aug;13(8):831-8 PMID: 908344
  5. The effect of vitamin A deficiency upon experimental oral carcinogenesis.
    J Dent Res. 1959 Jan-Feb;38(1):72-83 PMID: 13631138
  6. Vitamin A acid (retinoic acid), a potent inhibitor of 12-O-tetradecanoyl-phorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis.
    Cancer Res. 1977 Jul;37(7 Pt 1):2196-201 PMID: 861945
  7. A vitamin A analogue inhibits radiation-induced oncogenic transformation.
    Nature. 1978 Aug 3;274(5670):486-7 PMID: 672975
  8. Determination of binding affinities of retinoids to retinoic acid-binding protein and serum albumin.
    Biochem J. 1978 Jun 1;171(3):711-7 PMID: 666734
  9. Preventive role of vitamin A in colon carcinogenesis in rats.
    Cancer. 1977 Nov;40(5 Suppl):2553-6 PMID: 922696
  10. Relationships between structure and activity of retinoids.
    Nature. 1976 Sep 9;263(5573):110-3 PMID: 987541
  11. Inhibitory effects of retinoic acid or retinyl acetate on the growth of untransformed, transformed, and tumor cells in vitro.
    J Natl Cancer Inst. 1977 Dec;59(6):1717-22 PMID: 562945
  12. Effect of vitamin A on 7,12-Dimethylbenz(alpha)anthracene-induced papillomas in rhino mouse skin.
    Cancer Res. 1967 Feb;27(2):237-41 PMID: 6018557
  13. GROWTH PATTERN OF THE MOUSE PROSTATE GLAND IN ORGAN CULTURE AND ITS RESPONSE TO SEX HORMONES, VITAMIN A, AND 3-METHYLCHOLANTHRENE.
    Natl Cancer Inst Monogr. 1963 Oct;12:381-403 PMID: 14073011
  14. [Conservative treatment of recurrent papillomatosis of the urinary bladder with vitamin A acid. Preliminary report].
    Schweiz Med Wochenschr. 1972 Dec 23;102(51):1880-3 PMID: 4567350
  15. Retinoic acid inhibition of Epstein-Barr virus induction.
    Nature. 1979 Apr 5;278(5704):553-4 PMID: 219367
  16. Retinoic acid-binding protein in normal tissues and experimental tumors.
    Cancer Res. 1977 Jan;37(1):209-13 PMID: 830406
  17. [Clinical experiences with vitamin A acid derivatives in therapy of leukoplakia of the mouth mucosa].
    Dtsch Zahnarztl Z. 1973 May;28(5):623-7 PMID: 4513569
  18. Prophylaxis of chemically induced benign and malignant epithelial tumors by vitamin A acid (retinoic acid).
    Eur J Cancer. 1972 Dec;8(6):689-93 PMID: 4652000
  19. Therapeutic effects of an aromatic retinoic acid analog on chemically induced skin papillomas and carcinomas of mice.
    Eur J Cancer. 1974 Nov;10(11):731-7 PMID: 4469497
  20. Vitamin A AND VITAMIN A acid in the prophylaxis and therapy of epithelial tumours.
    Int Z Vitaminforsch. 1970;40(3):299-314 PMID: 4915969
  21. Biological activity and metabolism of the retinoid axerophthene (vitamin A hydrocarbon).
    Cancer Res. 1978 Jun;38(6):1734-8 PMID: 647683
  22. Antitumor action of vitamin A in mice inoculated with adenocarcinoma cells.
    J Natl Cancer Inst. 1975 Jun;54(6):1489-91 PMID: 1133855
  23. 13-cis-retinoic acid: inhibition of bladder carcinogenesis in the rat.
    Science. 1977 Feb 4;195(4277):487-9 PMID: 835006
  24. Mediation of retinoic acid-induced growth and anti-tumour activity.
    Nature. 1976 Mar 4;260(5546):49-51 PMID: 944375
  25. Therapy of epithelial tumors with an aromatic retinoic acid analog.
    Chemotherapy. 1975;21(3-4):236-47 PMID: 808401
  26. Activity of vitamin A analogues in cell cultures of mouse epidermis and organ cultures of hamster trachea.
    Nature. 1975 Jan 3;253(5486):47-50 PMID: 1110749
  27. Stimulatory effects of vitamin A analogs on induction of cell-mediated cytotoxicity in vivo.
    Cancer Res. 1979 Jan;39(1):55-8 PMID: 761198
  28. VITAMIN A, CAROTENOIDS AND CELL FUNCTION.
    Biol Rev Camb Philos Soc. 1965 Aug;40:422-61 PMID: 14343801
  29. Stimulation of immune response in lung cancer patients by vitamin A therapy.
    Oncology. 1977;34(5):234-8 PMID: 917457
  30. Adjuvanticity of vitamin A.
    Nature. 1968 Feb 10;217(5128):527-9 PMID: 4170941
  31. Influence of vitamin A on immunological response.
    Immunology. 1972 Sep;23(3):283-7 PMID: 4609898
  32. Biochemical treatment of precancerous oral lesions: the effectiveness of various analogues of retinoic acid.
    J Maxillofac Surg. 1978 Feb;6(1):59-63 PMID: 274508
  33. Retinoids, a new class of compounds with prophylactic and therapeutic activities in oncology and dermatology.
    Experientia. 1978 Sep 15;34(9):1105-19 PMID: 363444
  34. Inhibition of the effects of methylcholanthrene on mouse prostate in organ culture by vitamin A and its analogs.
    Cancer Res. 1974 Jul;34(7):1564-71 PMID: 4833910
  35. Histopathological evaluation of the inhibition of rat bladder carcinogenesis by 13-cis-retinoic acid.
    Cancer Res. 1977 Aug;37(8 Pt 2):2930-6 PMID: 872122
  36. Autoradiographic and histopathologic studies on the mode of action of an aromatic retinoid (Ro 10-9359) on chemically induced epithelial tumors in Swiss mice.
    J Natl Cancer Inst. 1977 May;58(5):1365-71 PMID: 404432
  37. Cellular binding proteins for vitamin A in colorectal adenocarcinoma of rat.
    Cancer Res. 1978 Dec;38(12):4422-6 PMID: 569012
  38. Inhibition of mammary cancer by retinyl methyl ether.
    Cancer Res. 1977 Feb;37(2):599-602 PMID: 401683
  39. Effects of vitamin A on 3-methylcholanthrene-induced squamous metaplasias and early tumors in the respiratory tract of rats.
    J Natl Cancer Inst. 1973 Jun;50(6):1599-606 PMID: 4717569
  40. [Vitamin A acid in the therapy of tumors. Local treatment of precancerous conditions and basal carcinoma of the skin with vitamin A acid].
    Schweiz Med Wochenschr. 1971 Jan 9;101(1):17-8 PMID: 5547625
  41. Retinoids block phenotypic cell transformation produced by sarcoma growth factor.
    Nature. 1978 Nov 16;276(5685):272-4 PMID: 213728
  42. Accelerated rejection of skin homografts by vitamin A acid.
    Transplantation. 1972 Nov;14(5):564-7 PMID: 4563196
  43. Possible role of retinoic acid binding protein in retinoid stimulation of embryonal carcinoma cell differentiation.
    Nature. 1979 Mar 8;278(5700):180-2 PMID: 763363
  44. Reversible inhibition by retinoids of 3-methylcholanthrene-induced neoplastic transformation in C3H/10T1/2 clone 8 cells.
    Cancer Res. 1979 May;39(5):1661-6 PMID: 427803
  45. Retinol induces density-dependent growth inhibition and changes in glycolipids and LETS.
    Nature. 1978 Jun 1;273(5661):379-81 PMID: 661949
  46. Inhibition of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis by retinyl acetate.
    Cancer Res. 1976 Jul;36(7 PT 2):2626-30 PMID: 819130
  47. N-(4-Hydroxyphenyl)retinamide, a new retinoid for prevention of breast cancer in the rat.
    Cancer Res. 1979 Apr;39(4):1339-46 PMID: 421218
  48. Inhibition of growth of Shope rabbit papilloma by hypervitaminosis A.
    Cancer Res. 1965 Aug;25(7):947-55 PMID: 5843270
  49. Reversal of methylcholanthrene-induced changes in mouse prostates in vitro by retinoic acid and its analogues.
    Br J Cancer. 1976 Sep;34(3):239-48 PMID: 987794
  50. Therapy of chemically induced skin tumors of mice with vitamin A palmitate and vitamin A acid.
    Experientia. 1971 Jan 15;27(1):90-2 PMID: 5549257
  51. Retinyl acetate inhibits mammary carcinogenesis induced by N-methyl-N-nitrosourea.
    Nature. 1977 Jun 16;267(5612):620-1 PMID: 876383
  52. Inhibition and reversal by beta-retinoic acid of hyperplasia induced in cultured mouse prostate tissue by 3-methylcholanthrene or N-methyl-N'-nitro-N-nitrosoguanidine.
    J Natl Cancer Inst. 1976 Mar;56(3):583-9 PMID: 943559
  53. Inhibition of vitamin A action in rat bone cultures by inhibitors of RNA and protein synthesis.
    Experientia. 1978 Sep 15;34(9):1159-61 PMID: 309826
  54. Correlation of the inhibition by retinoids of tumor promoter-induced mouse epidermal ornithine decarboxylase activity and of skin tumor promotion.
    Cancer Res. 1979 Feb;39(2 Pt 1):419-25 PMID: 761215
  55. Therapy of actinic keratoses and basal cell carcinomas with local application of vitamin A acid (NSC-122758).
    Cancer Chemother Rep. 1971 Feb;55(1):59-60 PMID: 5121652
  56. [The oral administration of vitamin-A-acid in leukoplakias, hyperkeratoses and squamous cell carcinomas: results and tolerance].
    Schweiz Med Wochenschr. 1971 Jul 17;101(28):1027-30 PMID: 5141778
  57. The effect of vitamin A acid on tumorigenesis and protein production.
    Cancer Res. 1968 Jun;28(6):1021-30 PMID: 5658437
  58. Experimental cancer of the lung. Inhibition by vitamin A of the induction of tracheobronchial squamous metaplasia and squamous cell tumors.
    Cancer. 1967 May;20(5):857-64 PMID: 6024294
  59. The direct involvement of vitamin A in glycosyl transfer reactions of mammalian membranes.
    Vitam Horm. 1977;35:1-57 PMID: 607563
  60. Inhibitory effect of 13-cis-retinoic acid on urinary bladder carcinogenesis induced in C57BL/6 mice by N-butyl-N-(4-hydroxybutyl)-nitrosamine.
    Cancer Res. 1978 Dec;38(12):4463-6 PMID: 719631
  61. Prophylaxis of chemically induced epithelial tumors with an aromatic retinoic acid analog (Ro 10-9359).
    Eur J Cancer. 1975 Oct;11(10):721-4 PMID: 812707
  62. Retinoic acid stimulation of the induction of mouse killer T-cells in allogeneic and syngeneic systems.
    J Natl Cancer Inst. 1979 Jan;62(1):89-94 PMID: 309967
  63. An inhibitory effect of vitamin A on the induction of tumors of forestomach and cervix in the Syrian hamster by carcinogenic polycyclic hydrocarbons.
    Cancer Res. 1965 Jul;25(6):884-95 PMID: 5891010
  64. [Effect of 2 retinoids (vitamin A analogs) on human bronchogenic carcinoma in vivo (nu/nu mouse) and in vitro].
    Schweiz Med Wochenschr. 1979 Jun 2;109(22):847-50 PMID: 462157
  65. Retinoic acid-binding protein in experimental tumors and in tissues with metastatic tumor foci.
    Cancer Res. 1977 Nov;37(11):4031-4 PMID: 561658
  66. Prophylaxis of chemically induced papillomas and carcinomas of mouse skin by vitamin A-acid.
    Experientia. 1972 Oct 15;28(10):1219-20 PMID: 4628815
  67. Inhibition of the growth and development of a transplantable murine melanoma by vitamin A.
    Science. 1975 Sep 12;189(4206):886-8 PMID: 1154026
  68. Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis by vitamin A analogs (retinoids).
    Cancer Res. 1978 Mar;38(3):793-801 PMID: 626983
  69. Toxicity of anti-carcinogenic retinoids in organ culture.
    Br J Cancer. 1977 Jan;35(1):115-9 PMID: 831757
  70. Characterization of the inhibitory effects of retinoids on the in vitro growth of two malignant murine melanomas.
    J Natl Cancer Inst. 1978 May;60(5):1035-41 PMID: 205660
  71. Different susceptibilities of human melanoma and breast carcinoma cell lines to retinoic acid-induced growth inhibition.
    Cancer Res. 1979 Mar;39(3):1014-9 PMID: 427741
  72. Inhibitory action of vitamin A on a murine sarcoma.
    Life Sci. 1973 Oct 1;13(7):945-52 PMID: 4766269
  73. The effect of vitamin A acid on glycoprotein synthesis in skin tumors (keratoacanthomas).
    Cancer Res. 1972 Oct;32(10):2248-52 PMID: 5080767
  74. Potentiating effect of vitamin A on 9-10 dimethyl 1-2 benzanthracene--carcinogenesis in the hamster cheek pouch.
    Cancer. 1968 Aug;22(2):300-6 PMID: 5660197
  75. Effects of vitamin A acid (NSC-122758) on transplantable and chemically induced tumors.
    Cancer Chemother Rep. 1971 Feb;55(1):53-8 PMID: 5121651
  76. Presence of cellular rentinol and retinoic acid binding proteins in experimental rumors.
    Cancer Lett. 1976 Sep;2(1):25-30 PMID: 1035129
  77. Retinoic acid and the restoration of anchorage dependent growth to transformed mammalian cells.
    Exp Cell Res. 1978 Nov;117(1):15-22 PMID: 720400
  78. Retinoic acid binding protein: occurrence in human tumors.
    Science. 1975 Oct 3;190(4209):60-1 PMID: 1166300
  79. Antitumor effect of a new retinoic acid analog.
    Experientia. 1974 Oct 15;30(10):1198-200 PMID: 4435135
  80. Retinoic acid-binding protein in human breast cancer and dysplasia.
    J Natl Cancer Inst. 1978 Dec;61(6):1375-8 PMID: 281544
  81. Effects of retinoic acid on the immune system: stimulation of T killer cell induction.
    Eur J Immunol. 1978 Jan;8(1):23-9 PMID: 346357
  82. Inhibition of growth and regression of a transplantable rat chondrosarcoma by three retinoids.
    Cancer Treat Rep. 1976 Nov;60(11):1647-53 PMID: 1021235
  83. Vitamin A-induced density-dependent inhibition of L-cell proliferation.
    J Natl Cancer Inst. 1977 Mar;58(3):795-801 PMID: 839572
Article Info
Journal
Cancer chemotherapy and pharmacology
Abbr.
Cancer Chemother Pharmacol
ISSN
0344-5704
DOI
10.1007/BF00254733
Published
1979-00-00
Pages
207-15
Language
English
Region
Germany
NLM ID
7806519
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00254733 View journal details
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