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PMID: 3973977 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Sequence analysis of the termini of virion and replicative forms of minute virus of mice DNA suggests a modified rolling hairpin model for autonomous parvovirus DNA replication.

Journal of virology ·Vol. 54 ·No. 1 ·1985-04-00 ·Pages 171-7

Astell CR, Chow MB, Ward DC

Abstract

The nucleotide sequences of the terminal regions of monomer replicative form DNA, a pivotal intermediate species in the replication of minute virus of mice, were determined. The left (3') terminus had a unique sequence on both strands and in both 3'-hairpin configurations. In contrast, the right (5') terminus was sequence heterogeneous and extended an additional 18 base pairs beyond that expected from the known sequence of the virion DNA. These data unambiguously establish the sequence complexity at the termini of both the single-stranded viral genome and the pool of replicative DNA. A comparison of the combined sequence information leads us to propose a modified rolling hairpin model for the replication of autonomous parvoviruses which is compatible with all available data.

MeSH Terms
Animals Base Sequence DNA Replication DNA, Viral/genetics Mice Parvoviridae/genetics Virus Replication
Chemicals
DNA, Viral
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Astell C R
Chow M B
Ward D C
References (22)
22 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.54.1.171-177.1985
Published
1985-04-00
Pages
171-7
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC254774
Subset
IM
Grants
NCI NIH HHS · CA-16038 · United States
NIGMS NIH HHS · GM-20124 · United States
Databases
GENBANK
M10895, M10896
External Links
PubMed source DOI: 10.1128/JVI.54.1.171-177.1985 PMC Full Text View journal details
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