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PMID: 4128386 Published · ppublish English Comparative Study Journal Article

Characterization of C-type particles produced by a tissue culture-adapted murine myeloma.

Journal of virology ·Vol. 12 ·No. 6 ·1973-12-00 ·Pages 1589-97

Volkman LE, Krueger RG

Abstract

C-type particles produced by a tissue culture-adapted BALB/c myeloma were characterized. It was determined that although the particles were morphologically and antigenically similar to murine leukemia and sarcoma virus, the size of their RNA was different, they lacked RNA-dependent DNA polymerase, they were unstable in NET buffer, sucrose and citrate but were stable in glycerol and Earle balanced salt solution, and they behaved differently from oncornaviruses when treated with ether and detergent.

MeSH Terms
Adenine Animals Cells, Cultured/microbiology Centrifugation, Density Gradient Ethyl Ethers/pharmacology Gammaretrovirus/analysis Mice Mice, Inbred BALB C Microscopy, Electron Multiple Myeloma Neoplasms, Experimental Phosphotungstic Acid RNA, Viral/analysis RNA-Directed DNA Polymerase/biosynthesis Retroviridae/analysis,drug effects,enzymology,isolation & purification Ribonucleases/pharmacology Staining and Labeling Surface-Active Agents/pharmacology Tritium Uridine
Chemicals
Ethyl Ethers RNA, Viral Surface-Active Agents Tritium Phosphotungstic Acid RNA-Directed DNA Polymerase Ribonucleases Adenine Uridine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Volkman L E
Krueger R G
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43 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.12.6.1589-1597.1973
Published
1973-12-00
Pages
1589-97
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC356802
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.12.6.1589-1597.1973 PMC Full Text View journal details
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