Abstract
PYRAN COPOLYMER, A KNOWN IMMUNOSTIMULATOR, WAS FOUND TO BE A POTENT INHIBITOR OF PURIFIED DNA POLYMERASE (DEOXYNUCLEOSIDETRIPHOSPHATE: DNA deoxynucleotidyltransferase; EC 2.7.7.7) isolated from avian myeloblastosis virus. Unlike other inhibitors, pyran showed unique features of inhibition. It interacts with the polymerase at a region other than the template site. The inhibitory effect was overcome only by excess enzyme and not affected by excess template. The degree of inhibition was not template specific for the templates tested: 70S RNA from avian myeloblastosis virus, synthetic hybrid poly(rA).oligo(dT)(10), synthetic copolymer poly(dA-dT), and activated calf-thymus DNA. The observed rate of inhibition by pyran was shown to vary with the different polymerases tested. Inhibition was shown with all oncornaviral polymerases and, to a lesser extent, with mammalian polymerases. However, two of the three bacterial polymerases, by contrast, showed a marked activation.
MeSH Terms
Adenine Nucleotides
Avian Leukosis Virus/enzymology
DNA/biosynthesis
Escherichia coli/enzymology
Kinetics
Micrococcus/enzymology
Molecular Weight
Nucleotides/metabolism
Polymers
Polynucleotides
Pyrans/pharmacology
RNA, Viral
RNA-Directed DNA Polymerase/metabolism
Rauscher Virus/enzymology
Retroviridae/enzymology
Reverse Transcriptase Inhibitors
Templates, Genetic
Thymine Nucleotides
Tritium
Chemicals
Adenine Nucleotides
Nucleotides
Polymers
Polynucleotides
Pyrans
RNA, Viral
Reverse Transcriptase Inhibitors
Thymine Nucleotides
Tritium
DNA
RNA-Directed DNA Polymerase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Papas T S
Pry T W
Chirigos M A
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20 references, click to expand
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