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PMID: 4359021 Published · ppublish English Journal Article

Phosphorylation of myelin basic protein by an adenosine 3':5'-cyclic monophosphate-dependent protein kinase.

The Biochemical journal ·Vol. 135 ·No. 3 ·1973-11-00 ·Pages 569-72

Carnegie PR, Kemp BE, Dunkley PR, Murray AW

Abstract

Myelin basic protein was shown to be a substrate for protein kinase from rabbit muscle. One of the major sites of phosphorylation was the serine residue in the sequence Gly-Arg-Gly-Leu-Ser-Leu. The arginine residue in this sequence is known to be a substrate for a protein methylase.

MeSH Terms
Animals Arginine Cyclic AMP/metabolism Glycine Leucine Muscles/enzymology Myelin Sheath Nerve Tissue Proteins/metabolism Protein Kinases/metabolism Rabbits Serine
Chemicals
Nerve Tissue Proteins Serine Arginine Cyclic AMP Protein Kinases Leucine Glycine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Carnegie P R
Kemp B E
Dunkley P R
Murray A W
References (11)
11 references, click to expand
  1. A simple method for the preparation of 32-P-labelled adenosine triphosphate of high specific activity.
    Biochem J. 1964 Jan;90(1):147-9 PMID: 5832284
  2. Esters of serine and threonine in hydrolysates of histones and protamines, and attendant errors in amino acid analyses of proteins.
    Biochem J. 1967 Nov;105(2):491-5 PMID: 5583992
  3. An adenosine 3',5'-monophosphate-dependant protein kinase from rabbit skeletal muscle.
    J Biol Chem. 1968 Jul 10;243(13):3763-5 PMID: 4298072
  4. Specific enzymic methylation of an arginine in the experimental allergic encephalomyelitis protein from human myelin.
    Science. 1971 Feb 12;171(3971):579-81 PMID: 4924231
  5. Amino acid sequence of the encephalitogenic basic protein from human myelin.
    Biochem J. 1971 Jun;123(1):57-67 PMID: 4108501
  6. Phosphorylation of endogenous protein of rat brain by cyclic adenosine 3',5'-monophosphate-dependent protein kinase.
    J Biol Chem. 1971 Dec 25;246(24):7731-9 PMID: 4332564
  7. Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species.
    Prep Biochem. 1972;2(2):139-65 PMID: 4623901
  8. Phosphorylation of ribosomal proteins by substrate-specific protein kinases from rabbit reticulocytes.
    Proc Natl Acad Sci U S A. 1973 Feb;70(2):373-6 PMID: 4346887
  9. Protein kinase activity in commercially available crystalline yeast alcohol dehydrogenase.
    Biochem J. 1973 Feb;131(2):271-4 PMID: 4352909
  10. Protein kinase activity in membrane preparations from ox brain. Stimulation of intrinsic activity by adenosine 3':5'-cyclic monophosphate.
    Biochem J. 1973 Mar;132(3):483-92 PMID: 4353379
  11. Protein kinases.
    Curr Top Cell Regul. 1972;5:99-133 PMID: 4358204
Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1350569
Published
1973-11-00
Pages
569-72
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1165865
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1350569 PMC Full Text View journal details
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