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PMID: 49442 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Quantitative nucleotide sequence relationships of mammalian RNA tumor viruses.

Journal of virology ·Vol. 15 ·No. 6 ·1975-06-00 ·Pages 1396-408

East JL, Knesek JE, Chan JC, Dmochowski L

Abstract

A molecular hybridization technique has been used to quantitatively measure the nucleotide sequence relationships of selected mammalian RNA tumor viruses. Reciprocal cross-hybridization tests were done in which a given radioactively labeled, viral genomic RNA species was annealed with an excess of unlabeled, complementary DNA product synthesized in endogenously instructed reverse transcriptase reactions. Hybrid formation was measured with pancreatic RNase A. Three representative mammalian RNA tumor virus groups were examined: murine viruses, simian viruses, and feline viruses. The results of reciprocal cross-hybridization testing have revealed that the murine viruses consist of four distinctly related subgroups: (i) the Friend leukemia virus/Rauscher leukemia virus subgroup, (ii) the Gross leukemia virus subgroup, (iii) the Moloney sarcoma virus subgroup, and (iv) the Kirsten sarcoma virus subgroup. Simian sarcoma virus, the only simian virus examined, appeared to share limited interspecies sequence relationships with members of the other virus groups and in particular with Kirsten sarcoma virus. Of the two members of the feline virus group tested, Rickard feline sarcoma virus and RD-114, each was placed in a separate, unrelated subgroup. Rickard feline sarcoma virus exhibited limited sequence relatedness with members of the other virus groups, whereas RD-114 exhibited none.

MeSH Terms
Animals Base Sequence Cats Cell-Free System DNA, Single-Stranded/biosynthesis DNA, Viral/biosynthesis Dactinomycin/pharmacology Gammaretrovirus/analysis,classification Haplorhini Hot Temperature Nucleic Acid Denaturation Nucleic Acid Hybridization Nucleotides/analysis RNA, Viral/analysis RNA-Directed DNA Polymerase/metabolism Retroviridae/analysis,classification
Chemicals
DNA, Single-Stranded DNA, Viral Nucleotides RNA, Viral Dactinomycin RNA-Directed DNA Polymerase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
East J L
Knesek J E
Chan J C
Dmochowski L
References (41)
41 references, click to expand
  1. C-type virus released from cultured human rhabdomyosarcoma cells.
    Nat New Biol. 1972 Jan 5;235(53):3-6 PMID: 4111969
  2. Purification of large amounts of murine ribonucleic acid tumor viruses produced in roller bottle cultures.
    Appl Microbiol. 1972 Sep;24(3):488-94 PMID: 4116893
  3. Particles containing RNA-instructed DNA polymerase and virus-related RNA in human breast cancers.
    Proc Natl Acad Sci U S A. 1972 Nov;69(11):3133-7 PMID: 4117770
  4. Detection of avian tumor virus RNA in uninfected chicken embryo cells.
    J Virol. 1973 Feb;11(2):157-67 PMID: 4120205
  5. RNA in mammalian sarcoma virus transformed nonproducer cells homologous to murine leukemia virus RNA.
    Virology. 1973 Feb;51(2):370-82 PMID: 4120907
  6. Molecular relatedness of mammalian RNA tumor viruses as determined by DNA hybridization.
    Science. 1973 Jun 1;180(4089):972-4 PMID: 4122422
  7. Lack of sequence homology among RNAs of avian leukosis-sarcoma viruses, reticuloendotheliosis viruses, and chicken endogenous RNA-directed DNA polymerase activity.
    J Virol. 1973 Dec;12(6):1314-24 PMID: 4128378
  8. Cell-free transmission in adult Swiss mice of a disease having the character of a leukemia.
    J Exp Med. 1957 Apr 1;105(4):307-18 PMID: 13416470
  9. Protein measurement with the Folin phenol reagent.
    J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
  10. Properties of incomplete Sendai virions and subgenomic viral RNAs.
    Virology. 1970 Dec;42(4):857-71 PMID: 4099084
  11. Primate RNA tumor virus-like DNA synthesized endogenously by RNA-dependent DNA polymerase in virus-like particles from fresh human acute leukemic blood cells.
    Proc Natl Acad Sci U S A. 1973 Nov;70(11):3219-24 PMID: 4131745
  12. Systematics of RNA tumor viruses and virus-like particles of human origin.
    Proc Natl Acad Sci U S A. 1974 Aug;71(8):3177-81 PMID: 4137960
  13. RNA-directed DNA synthesis by virions of Rous sarcoma virus: further characterization of the templates and the extent of their transcription.
    Virology. 1973 Mar;52(1):264-74 PMID: 4139806
  14. Isolation of naturally occurring viruses of the murine leukemia virus group in tissue culture.
    J Virol. 1969 Feb;3(2):126-32 PMID: 4304442
  15. RNA-dependent DNA polymerase in virions of RNA tumour viruses.
    Nature. 1970 Jun 27;226(5252):1209-11 PMID: 4316300
  16. Complementarity between Rous sarcoma virus (RSV) RNA and the in vitro-synthesized DNA of the virus-associated DNA polymerase.
    Virology. 1970 Nov;42(3):783-8 PMID: 4320669
  17. Heterogeneity of murine leukemia virus in vitro DNA; detection of viral DNA in mammalian cells.
    Science. 1971 Jun 25;172(3990):1353-5 PMID: 4325521
  18. Detection of antigens of the mouse mammary tumor (MTV) and murine leukemia virus (MuLV) in cells of cultures derived from mammary tumors of mice of several strains.
    Virology. 1971 Aug;45(2):470-83 PMID: 4328811
  19. Extent of transcription by the RNA-dependent DNA polymerase of Rous sarcoma virus.
    Nat New Biol. 1971 Sep 1;233(35):19-21 PMID: 4329249
  20. Murine sarcoma and leukemia viruses: genetic differences determined by RNA-DNA hybridization.
    Virology. 1971 Nov;46(2):480-4 PMID: 4331733
  21. Human sarcomas contain RNA related to the RNA of a mouse leukemia virus.
    Science. 1972 Jan 14;175(4018):182-5 PMID: 4332759
  22. RNA related to that of a murine leukemia virus in Burkitt's tumors and nasopharyngeal carcinomas.
    Proc Natl Acad Sci U S A. 1973 Jan;70(1):5-9 PMID: 4346039
  23. Structural rearrangement and subunit composition of RNA from released Soehner-Dmochowski murine sarcoma virions.
    J Virol. 1973 May;11(5):709-20 PMID: 4350715
  24. Early synthesis of virus-specific RNA and DNA in cells rapidly transformed with Rous sarcoma virus.
    Virology. 1973 Dec;56(2):532-48 PMID: 4357055
  25. Transcription of mouse mammary tumor virus genes in tissues from high and low tumor incidence mouse strains.
    J Mol Biol. 1973 Oct 5;79(4):663-79 PMID: 4357097
  26. Homology between type-C viruses of various species as determined by molecular hybridization.
    Proc Natl Acad Sci U S A. 1973 Dec;70(12):3316-20 PMID: 4357865
  27. Strandedness and complementarity of DNA from long-term RNA-dependent DNA polymerase reactions of Soehner-Dmochowski murine sarcoma virus.
    J Virol. 1973 Nov;12(5):1049-64 PMID: 4358160
  28. Structural characteristics and nucleotide sequence analysis of genomic RNA from RD-114 virus and feline RNA tumor viruses.
    J Virol. 1973 Nov;12(5):1085-91 PMID: 4358162
  29. Evidence that the AKR murine-leukemia-virus genome is complete in DNA of the high-virus AKR mouse and incomplete in the DNA of the "virus-negative" NIH mouse.
    Proc Natl Acad Sci U S A. 1974 Jan;71(1):167-71 PMID: 4359326
  30. Homologies among the nucleotide sequences of the genomes of C-type viruses.
    Virology. 1974 Apr;58(2):568-75 PMID: 4362434
  31. Nucleotide sequence relationships of avian RNA tumor viruses: measurement of the deletion in a transformation-defective mutant of Rous sarcoma virus.
    J Virol. 1974 Apr;13(4):837-46 PMID: 4362512
  32. Harvey sarcoma virus: a second murine type C sarcoma virus with rat genetic information.
    J Virol. 1974 Jun;13(6):1211-9 PMID: 4364897
  33. Requirement for cell division for initiation of transcription of Rous sarcoma virus RNA.
    J Virol. 1974 Sep;14(3):531-46 PMID: 4369144
  34. The relationship between mismatched base pairs and the thermal stability of DNA duplexes. II. Effects of deamination of cytosine.
    Biochim Biophys Acta. 1973 Feb 4;294(1):416-24 PMID: 4574654
  35. The use of RNA labeled in vitro with iodine-125 in molecular hybridization experiments.
    Biochim Biophys Acta. 1972 Dec 22;287(3):485-94 PMID: 4629777
  36. A comparative study of the biologic and molecular basis of murine mammary carcinoma: a model for human breast cancer.
    J Natl Cancer Inst. 1973 Aug;51(2):541-51 PMID: 4797259
  37. Intracellular viral RNA species in mouse cells nonproductively transformed by the murine sarcoma virus.
    J Virol. 1974 Sep;14(3):587-91 PMID: 4852536
  38. The rate of change of DNA in evolution.
    Brookhaven Symp Biol. 1972;23:1-43 PMID: 5047198
  39. Induction of bone tumours in rats and hamsters with murine sarcoma virus and their cell-free transmission.
    Nature. 1969 Oct 11;224(5215):191-2 PMID: 5259233
  40. Forms of deoxyribonucleic acid produced by virions of the ribonucleic acid tumor viruses.
    J Virol. 1971 Jan;7(1):106-11 PMID: 5543423
  41. Newcastle disease virus RNA. II. Preferential synthesis of RNA complementary to parental viral RNA by chick embryo cells.
    J Mol Biol. 1966 Jun;18(1):204-14 PMID: 5965050
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.15.6.1396-1408.1975
Published
1975-06-00
Pages
1396-408
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC354607
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.15.6.1396-1408.1975 PMC Full Text View journal details
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