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PMID: 6157644 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Intra-H-2 recombination in the mouse. III. I-Region characterization of haplotypes H-2at2, H-2at3 and H-2a2.

Immunogenetics ·Vol. 11 ·No. 2 ·1980-00-00 ·Pages 123-30

Beisel KW, Passmore HC, David CS

Abstract

Serological characterization of three K-S interval recombinant strains, TBR2 (H-2at2), TBR3 (H-2at3) and AIR 1 (H-2a2) was performed using anti-H-2, Ia, Ss and Slp antisera. The data presented here reveal that the crossover events in both TBR2 and TBR3 occurred between the I-A and I-E subregions. In both cases, the H-2K and I-A subregions were derived fron the H-2t1 of chromosome, while the I-E, S and H-2D regions were derived from the H-2b chromosome (KsAkEbSbDb). The H-2a2 chromosome resulted from a crossover event between the H-2a1 and H-2i9 chromosomes. Ia and Ss typing of AIR 1 suggested that the K to I-E regions originated from H-2a1 and the S and D regions originated from H-2i9 (KkAkEkSbDd).

MeSH Terms
Animals Chromosome Mapping Crossing Over, Genetic Epitopes Genes, MHC Class II H-2 Antigens/genetics,immunology Mice Mice, Inbred Strains/genetics Recombination, Genetic
Chemicals
Epitopes H-2 Antigens
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Beisel K W
Passmore H C
David C S
References (27)
27 references, click to expand
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Article Info
Journal
Immunogenetics
Abbr.
Immunogenetics
ISSN
0093-7711
DOI
10.1007/BF01567778
Published
1980-00-00
Pages
123-30
Language
English
Region
United States
NLM ID
0420404
Subset
IM
Grants
NIAID NIH HHS · AI-0525 · United States
NIAID NIH HHS · AI-14424 · United States
NIAID NIH HHS · AI-14764 · United States
External Links
PubMed source DOI: 10.1007/BF01567778 View journal details
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