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PMID: 6174424 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Interferon-induced changes in the monocyte membrane: inhibition by retinol and retinoic acid.

Immunology ·Vol. 45 ·No. 3 ·1982-03-00 ·Pages 531-6

Rhodes J, Stokes P

Abstract

The effects of human interferon-beta on human peripheral blood monocyte function were examined in vitro. Interferon-beta was shown to increase substantially the expression of both Fc gamma receptors and HLA-DR antigens defined by monoclonal antibody. Retinol and retinoic acid were found to be antagonistic to these effects of interferon and physiological concentrations were sufficient to inhibit changes in the monocyte membrane induced by relatively high concentrations of interferon.

MeSH Terms

Cell Membrane/drug effects,immunology Cells, Cultured HLA-DR Antigens Histocompatibility Antigens Class II/immunology Humans Interferons/antagonists & inhibitors,pharmacology Monocytes/drug effects,immunology Receptors, Fc/immunology Rosette Formation Tretinoin/pharmacology Vitamin A/pharmacology

Chemicals

HLA-DR Antigens Histocompatibility Antigens Class II Receptors, Fc Vitamin A Tretinoin Interferons

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Rhodes J

Stokes P

References (29)

29 references, click to expand

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Article Info

Journal

Immunology

Abbr.

Immunology

ISSN

0019-2805

Published

1982-03-00

Pages

531-6

Language

English

Region

England

NLM ID

0374672

PMCID

PMC1555242

Subset

External Links

PubMed source PMC Full Text View journal details

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Interferon-induced changes in the monocyte membrane: inhibition by retinol and retinoic acid.

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