Home LiteratureArticle Details
PMID: 6300779 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Association of two different repetitive DNA elements near immunoglobulin light chain genes.

Nucleic acids research ·Vol. 11 ·No. 6 ·1983-03-25 ·Pages 1803-17

Wilson R, Storb U

Abstract

Sequence studies of repetitive DNA elements approximately 6 kb 3' of the mouse immunoglobulin CK region gene show that the R element located there (Gebhard et al. (1982) J. Mol. Biol. 157, 453-471) is adjacent to a 500 base pair long element which shows 80% homology to the BAM5 element sequenced by Fanning (Nuc. Acids Res. (1982), 10, 5003-5013). Neither the BAM5 element nor the R element itself is surrounded by a direct repeat, but the composite element (BAM5 + R) is surrounded by a 15 base pair direct repeat (with one mismatch). Direct repeats, consisting of target site sequences that surround a repetitive DNA element, are thought to arise during the insertion of the element at that site. It therefore appears that the BAM5 and R elements interacted and inserted as a linked entity. The existence of other BAM5/R composites throughout the mouse lambda chain locus indicates that BAM5-R cooperation is not a rare event.

MeSH Terms
Animals Cloning, Molecular Cricetinae DNA/genetics DNA Restriction Enzymes Genes Immunoglobulin Constant Regions/genetics Immunoglobulin Light Chains/genetics Immunoglobulin kappa-Chains/genetics Immunoglobulin lambda-Chains/genetics Immunoglobulins/genetics Liver/immunology Mice Nucleic Acid Hybridization Repetitive Sequences, Nucleic Acid Species Specificity
Chemicals
Immunoglobulin Constant Regions Immunoglobulin Light Chains Immunoglobulin kappa-Chains Immunoglobulin lambda-Chains Immunoglobulins DNA DNA Restriction Enzymes
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Wilson R
Storb U
References (35)
35 references, click to expand
  1. Analysis of the regions flanking the human insulin gene and sequence of an Alu family member.
    Nucleic Acids Res. 1980 Sep 25;8(18):4091-109 PMID: 6253909
  2. The nucleotide sequence of the ubiquitous repetitive DNA sequence B1 complementary to the most abundant class of mouse fold-back RNA.
    Nucleic Acids Res. 1980 Mar 25;8(6):1201-15 PMID: 7433120
  3. Novel classes of mouse repeated DNAs.
    Nucleic Acids Res. 1980 Aug 11;8(15):3247-58 PMID: 6160469
  4. Comparison of different rearranged immunoglobulin kappa genes of a myeloma by electronmicroscopy and restriction mapping of cloned DNA: implications for "allelic exclusion".
    Nucleic Acids Res. 1980 Oct 24;8(20):4689-707 PMID: 6255429
  5. Structure and organization of the highly repeated and interspersed 1.3 kb EcoRI-Bg1II sequence family in mice.
    Nucleic Acids Res. 1980 Nov 11;8(21):5031-42 PMID: 6255440
  6. A family of long reiterated DNA sequences, one copy of which is next to the human beta globin gene.
    Nucleic Acids Res. 1980 Dec 20;8(24):6113-28 PMID: 6258162
  7. A system for shotgun DNA sequencing.
    Nucleic Acids Res. 1981 Jan 24;9(2):309-21 PMID: 6259625
  8. Transcription of single-copy vitellogenin gene of Xenopus involves expression of middle repetitive DNA.
    Nature. 1981 Jun 4;291(5814):429-31 PMID: 6264307
  9. Repetitive sequences of the sea urchin genome. Distribution of members of specific repetitive families.
    J Mol Biol. 1981 Jan 5;145(1):5-28 PMID: 7265203
  10. Physical linkage of the constant region genes for immunoglobulins lambda I and lambda III.
    Proc Natl Acad Sci U S A. 1981 Jun;78(6):3829-33 PMID: 6267606
  11. Somatic mutation of immunoglobulin light-chain variable-region genes.
    Cell. 1981 Jul;25(1):47-58 PMID: 6791832
  12. Repetitive DNA sequences cotranscribed with developmentally regulated Dictyostelium discoideum mRNAs.
    Proc Natl Acad Sci U S A. 1981 Sep;78(9):5386-90 PMID: 6946479
  13. Repetitive sequences of the sea urchin genome. III. Nucleotide sequences of cloned repeat elements.
    J Mol Biol. 1981 Jun 15;149(1):41-67 PMID: 7310878
  14. Low molecular weight RNAs transcribed in vitro by RNA polymerase III from Alu-type dispersed repeats in Chinese hamster DNA are also found in vivo.
    Proc Natl Acad Sci U S A. 1981 Oct;78(10):6130-4 PMID: 6796957
  15. Direct repeats flank three small nuclear RNA pseudogenes in the human genome.
    Cell. 1981 Oct;26(1 Pt 1):11-7 PMID: 6173130
  16. Organization and evolutionary progress of a dispersed repetitive family of sequences in widely separated rodent genomes.
    J Mol Biol. 1981 Aug 25;150(4):441-66 PMID: 6276556
  17. Base sequence studies of 300 nucleotide renatured repeated human DNA clones.
    J Mol Biol. 1981 Sep 5;151(1):17-33 PMID: 6276559
  18. Short interspersed repetitive DNA elements in eucaryotes: transposable DNA elements generated by reverse transcription of RNA pol III transcripts?
    Cell. 1981 Oct;26(2 Pt 2):141-2 PMID: 6277493
  19. A monkey Alu sequence is flanked by 13-base pair direct repeats by an interrupted alpha-satellite DNA sequence.
    Proc Natl Acad Sci U S A. 1982 Mar;79(5):1497-500 PMID: 6280186
  20. Sequence organization and genomic distribution of the major family of interspersed repeats of mouse DNA.
    Proc Natl Acad Sci U S A. 1982 Jan;79(2):355-9 PMID: 6281768
  21. The Alu family of dispersed repetitive sequences.
    Science. 1982 Jun 4;216(4550):1065-70 PMID: 6281889
  22. Human 7SL RNA consists of a 140 nucleotide middle-repetitive sequence inserted in an alu sequence.
    Cell. 1982 May;29(1):195-202 PMID: 6179628
  23. A new family of interspersed repetitive DNA sequences in the mouse genome.
    J Mol Biol. 1982 May 25;157(3):453-71 PMID: 6927852
  24. Evolution of mouse immunoglobulin lambda genes.
    Proc Natl Acad Sci U S A. 1982 Aug;79(15):4681-5 PMID: 6812053
  25. Characterization of a highly repetitive family of DNA sequences in the mouse.
    Nucleic Acids Res. 1982 Aug 25;10(16):5003-13 PMID: 6290999
  26. Detection of specific sequences among DNA fragments separated by gel electrophoresis.
    J Mol Biol. 1975 Nov 5;98(3):503-17 PMID: 1195397
  27. Regulation of gene expression: possible role of repetitive sequences.
    Science. 1979 Jun 8;204(4397):1052-9 PMID: 451548
  28. A ubiquitous family of repeated DNA sequences in the human genome.
    J Mol Biol. 1979 Aug 15;132(3):289-306 PMID: 533893
  29. The organization of repetitive sequences in a cluster of rabbit beta-like globin genes.
    Cell. 1980 Feb;19(2):379-91 PMID: 6244107
  30. Selfish DNA: the ultimate parasite.
    Nature. 1980 Apr 17;284(5757):604-7 PMID: 7366731
  31. Ubiquitous, interspersed repeated sequences in mammalian genomes.
    Proc Natl Acad Sci U S A. 1980 Mar;77(3):1398-402 PMID: 6246492
  32. DNA sequence of baboon highly repeated DNA: evidence for evolution by nonrandom unequal crossovers.
    Proc Natl Acad Sci U S A. 1980 Apr;77(4):2129-33 PMID: 6246524
  33. Organization and sequence studies of the 17-piece chicken conalbumin gene.
    Nature. 1979 Dec 6;282(5739):567-74 PMID: 551292
  34. Transposable elements.
    Cell. 1980 Jul;20(3):579-95 PMID: 6251969
  35. A family of moderately repetitive sequences in mouse DNA.
    Nucleic Acids Res. 1980 Sep 25;8(18):4075-90 PMID: 6253908
Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/11.6.1803
Published
1983-03-25
Pages
1803-17
Language
English
Region
England
NLM ID
0411011
PMCID
PMC325837
Subset
IM
Grants
NCI NIH HHS · CA/AI 25754 · United States
NIDCR NIH HHS · DE 02600 · United States
Databases
GENBANK
J00588, J00589, K00879, K00882, L00028
External Links
PubMed source DOI: 10.1093/nar/11.6.1803 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2