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PMID: 6571217 Published · ppublish English Journal Article

A prevalent persistent global nonrandomness that distinguishes coding and non-coding eucaryotic nuclear DNA sequences.

Journal of molecular evolution ·Vol. 19 ·No. 2 ·1983-00-00 ·Pages 122-33

Blaisdell BE

Abstract

Coding sequences of eucaryotic nuclear DNA were characterized by an excess of short runs and a deficit of long runs of weak and of strong hydrogen bounding bases; non-coding sequences by a deficit of short runs and an excess of long runs, in the same of purines and of pyrimidines. The conservation of these attributes across DNA sequences coding for proteins of widely different function, across widely different eucaryotic species for the same protein and across related genes that diverged a long time ago and that now show large differences in base and, if coding, amino acid sequence suggested that these attributes have survival value. It was concluded that these attributes constitute probalistic constraints on the primary structure (base sequence) of both coding and non-coding DNA.

MeSH Terms
Animals Base Sequence DNA Electronic Data Processing Eukaryotic Cells/ultrastructure Genetic Code Humans Introns Probability Proteins/genetics
Chemicals
Proteins DNA
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Blaisdell B E
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Article Info
Journal
Journal of molecular evolution
Abbr.
J Mol Evol
ISSN
0022-2844
DOI
10.1007/BF02300750
Published
1983-00-00
Pages
122-33
Language
English
Region
Germany
NLM ID
0360051
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02300750 View journal details
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