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PMID: 7034532 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

The modes of inheritance of insulin-dependent diabetes mellitus or the genetics of IDDM, no longer a nightmare but still a headache.

American journal of human genetics ·Vol. 33 ·No. 6 ·1981-11-00 ·Pages 835-51

Rotter JI

Abstract

The discovery of HLA antigen associations with juvenile-type insulin-dependent diabetes mellitus (IDDM) provided strong evidence separating this disorder, or group of disorders, from maturity-type noninsulin-dependent diabetes, as well as adding to the evidence for an immunologic pathogenesis. In addition, it was hoped that the use of these disease-marker associations in appropriate studies might clarify the genetics of IDDM. While these associations have provided a useful tool to further investigate the genetics and pathogenesis of IDDM, the mode or modes of inheritance of this group of disorders remain an area of great controversy. Susceptibility to IDDM is currently being proposed as being inherited as a single autosomal dominant, as a single autosomal recessive, as recessive and some dominant forms, in an intermediate gene dosage model, in a heterogeneous three-allele or two HLA loci model, and as a two-locus disorder. The arguments for each of these proposals is presented, as well as the problems of each. We surmise that the weight of evidence supports the heterogeneity hypothesis but that the modes of inheritance of IDDM will be fully resolved only when we can more reliably identify the diabetogenic genotype, rather than being limited in our investigations to the study of only full-blown clinical disease.

MeSH Terms
Chromosome Mapping Diabetes Mellitus, Type 1/genetics Gene Frequency Genes, Dominant Genes, Recessive Genetic Linkage Genetic Markers Genetic Predisposition to Disease Genotype HLA Antigens/genetics Humans Insulin/physiology Insulin Antibodies/genetics Models, Genetic
Chemicals
Genetic Markers HLA Antigens Insulin Insulin Antibodies
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Rotter J I
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1981-11-00
Pages
835-51
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1685168
Subset
IM
Grants
NIADDK NIH HHS · AM-00523 · United States
NIADDK NIH HHS · AM-25834 · United States
External Links
PubMed source PMC Full Text View journal details
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