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PMID: 7507301 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Vascular origin of Kaposi's sarcoma. Expression of leukocyte adhesion molecule-1, thrombomodulin, and tissue factor.

The American journal of pathology ·Vol. 144 ·No. 1 ·1994-01-00 ·Pages 51-9

Zhang YM, Bachmann S, Hemmer C, van Lunzen J, von Stemm A, Kern P, Dietrich M, Ziegler R, Waldherr R, Nawroth PP

Abstract

We studied seven cases of Kaposi's sarcomas (KS) obtained from patients with AIDS and one KS from a patient without HIV infection. Antigen expression was studied by immunocytochemistry and mRNA expression by in situ hybridisation. The markers tested were endothelial leukocyte adhesion molecule-1, thrombomodulin, and tissue factor. In all tumors (AIDS and non-AIDS associated) these markers reacted positive, indicating transcription and translation of these genes in KS. The synthesis and expression of tissue factor and thrombomodulin suggests that KS is a tumor that has tissue factor-mediated thrombin formation under the control of thrombomodulin. The expression of thrombomodulin and endothelial leukocyte adhesion molecule-1 provides evidence for the vascular origin of KS.

MeSH Terms
Acquired Immunodeficiency Syndrome/complications Adult Aged Aged, 80 and over Blood Vessels/physiology Cell Adhesion Cell Adhesion Molecules/metabolism E-Selectin Humans Immunohistochemistry In Situ Hybridization Sarcoma, Kaposi/etiology,metabolism,pathology Thrombomodulin/metabolism Thromboplastin/metabolism
Chemicals
Cell Adhesion Molecules E-Selectin Thrombomodulin Thromboplastin
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Zhang Y M
Department of Medicine, Pathology and Anatomy, University of Heidelberg, Germany.
Bachmann S
Hemmer C
van Lunzen J
von Stemm A
Kern P
Dietrich M
Ziegler R
Waldherr R
Nawroth P P
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1994-01-00
Pages
51-9
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1887124
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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