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PMID: 773296 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Synergy in the antimicrobial action of penicillin and beta-chloro-D-alanine in vitro.

Antimicrobial agents and chemotherapy ·Vol. 9 ·No. 2 ·1976-02-00 ·Pages 347-9

Soper TS, Manning JM

Abstract

beta-Chloro-d-alanine and penicillin G acted on early and late steps, respectively, in the biosynthesis of the bacterial cell wall. In combination these compounds showed a synergistic effect on the growth of Salmonella typhimurium and of Escherichia coli in vitro.

MeSH Terms
Alanine/analogs & derivatives,pharmacology Drug Synergism Escherichia coli/drug effects Microbial Sensitivity Tests Penicillin G/pharmacology Penicillin Resistance Penicillins/pharmacology Time Factors
Chemicals
Penicillins Alanine Penicillin G
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Soper T S
Manning J M
References (12)
12 references, click to expand
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    Nature. 1964 Feb 29;201:868-9 PMID: 14132774
  4. POTENTIATION OF PENICILLIN ACTION BY INHIBITION OF PENICILLINASE.
    Nature. 1964 Feb 29;201:867-8 PMID: 14132773
  5. Inhibition of bacterial growth by beta-chloro-D-alanine.
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    J Bacteriol. 1970 Oct;104(1):34-44 PMID: 4919751
  9. Lysis enhancement: a novel form of interaction between beta-lactam antibiotics.
    J Med Microbiol. 1975 Feb;8(1):205-8 PMID: 1092867
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    Antimicrob Agents Chemother. 1975 Apr;7(4):431-4 PMID: 1147579
  11. Mechanis of chlorampenicol-cephalordine synergism on Enerobacteiaeae.
    Antimicrob Agents Chemother. 1975 Jun;7(6):845-9 PMID: 1155928
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.9.2.347
Published
1976-02-00
Pages
347-9
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC429525
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.9.2.347 PMC Full Text View journal details
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