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PMID: 7951851 Published · ppublish English Journal Article

Serum levels of cytokines in patients with colorectal cancer: possible involvement of interleukin-6 and interleukin-8 in hematogenous metastasis.

Journal of gastroenterology ·Vol. 29 ·No. 4 ·1994-08-00 ·Pages 423-9

Ueda T, Shimada E, Urakawa T

Abstract

Serum levels of interleukin-1 (IL-1 beta), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor (TNF-alpha), and granulocyte-macrophage colony-stimulating factor (GM-CSF) were measured preoperatively in 24 patients with colorectal cancer. IL-1 beta was not elevated, IL-6 and IL-8 were markedly elevated, and GM-CSF was slightly elevated. TNF-alpha was not detected in most patients. Serum IL-6 levels correlated closely with serum IL-8 levels and with serum carbohydrate antigen (CA) 19-9 levels. Serum IL-6 levels were significantly higher in patients whose tumors exceeding 5.0 cm in diameter or spreading circumferentially. Serum IL-8 levels showed significant differences according to histological type, being lower in well differentiated adenocarcinoma compared to other types. Serum levels of IL-6 and IL-8 were significantly higher in patients with liver metastasis than in those without liver metastasis and serum levels of both these cytokines were also significantly higher in patients with lung metastasis than in those without lung metastasis. These results suggest that IL-6 and IL-8 may play an important role in the hematogenous metastasis of colorectal cancer.

MeSH Terms
Adenocarcinoma/blood,immunology,pathology Aged CA-19-9 Antigen/blood Colorectal Neoplasms/blood,immunology,pathology Cytokines/blood Female Granulocyte-Macrophage Colony-Stimulating Factor/blood Humans Interleukin-1/blood Interleukin-6/blood Interleukin-8/blood Liver Neoplasms/blood,immunology,secondary Lung Neoplasms/blood,immunology,secondary Male Neoplastic Cells, Circulating/metabolism Regression Analysis Tumor Necrosis Factor-alpha/analysis
Chemicals
CA-19-9 Antigen Cytokines Interleukin-1 Interleukin-6 Interleukin-8 Tumor Necrosis Factor-alpha Granulocyte-Macrophage Colony-Stimulating Factor
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ueda T
Department of Surgery, Kobe Rosai Hospital, Japan.
Shimada E
Urakawa T
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Article Info
Journal
Journal of gastroenterology
Abbr.
J Gastroenterol
ISSN
0944-1174
DOI
10.1007/BF02361238
Published
1994-08-00
Pages
423-9
Language
English
Region
Japan
NLM ID
9430794
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02361238 View journal details
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