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PMID: 8099544 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The oncogenic potential of Pax genes.

The EMBO journal ·Vol. 12 ·No. 6 ·1993-06-00 ·Pages 2361-7

Maulbecker CC, Gruss P

Abstract

Our results demonstrate that murine paired domain-containing genes (Pax) can promote oncogenesis in tissue culture cells and in mice, and should thus be classified as a novel group of proto-oncogenes. The induction of tumor formation in mice was dependent on a functional paired domain, but did not require the presence of a homeodomain. Consequently, not only the Pax-3 and Pax-6 proteins, which in addition to paired domains contain intact homeodomains, but also Pax-2 and Pax-8, containing only residual homeodomains, and Pax-1, completely lacking a homeodomain, were able to induce transformation of cell cultures and tumor formation in mice. The oncogenic potential of the Pax proteins is dependent on the DNA binding function of the paired motif, as the Un-Pax-1 protein, which carries a point mutation in this domain that impairs DNA binding, is also defective in tumor formation. Therefore, the Pax gene products are not only involved in controlling embryogenesis, but they can, if deregulated, also induce tumorigenesis.

Related Genes
Pax
MeSH Terms
3T3 Cells Animals Base Sequence Carcinogenicity Tests Cell Transformation, Neoplastic/genetics DNA-Binding Proteins/genetics Genes, Homeobox Male Mice Mice, Nude Molecular Sequence Data Oligodeoxyribonucleotides Oncogenes
Chemicals
DNA-Binding Proteins Oligodeoxyribonucleotides
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Maulbecker C C
Department of Molecular Cell Biology, Max-Planck Institute of Biophysical Chemistry, Göttingen, Germany.
Gruss P
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36 references, click to expand
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1993-06-00
Pages
2361-7
Language
English
Region
England
NLM ID
8208664
PMCID
PMC413466
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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