Targeting of viral glycoproteins to the Golgi complex.

Trends in microbiology ·Vol. 1 ·No. 4 ·1993-07-00 ·Pages 124-30

Hobman TC

Abstract

Certain enveloped viruses are known to assemble on membranes of the Golgi complex. Intracellular budding is facilitated by targeting of the viral glycoproteins to this organelle. It is likely that these viral glycoproteins are retained in the Golgi by the same means as are endogenous Golgi proteins. Consequently, the study of Golgi-specific viral proteins has provided important clues to the nature of Golgi retention signals.

MeSH Terms

Animals Biological Transport Bunyaviridae CHO Cells Coronaviridae Cricetinae Glycoproteins/metabolism Golgi Apparatus/metabolism RNA Viruses/metabolism Rubella virus Viral Proteins/metabolism

Chemicals

Glycoproteins Viral Proteins

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Hobman T C

Division of Cellular and Molecular Medicine, University of California, San Diego, La Jolla 92093-0651.

References (56)

56 references, click to expand

Overlapping distribution of two glycosyltransferases in the Golgi apparatus of HeLa cells.
J Cell Biol. 1993 Jan;120(1):5-13 PMID: 8416995
Coronavirus E1 glycoprotein expressed from cloned cDNA localizes in the Golgi region.
J Virol. 1987 Jun;61(6):2042-5 PMID: 3033331
Efficient transport of Semliki Forest virus glycoproteins through a Golgi complex morphologically altered by Uukuniemi virus glycoproteins.
EMBO J. 1986 Dec 1;5(12):3111-8 PMID: 3545812
Posttranslational processing of Uukuniemi virus glycoproteins G1 and G2.
J Virol. 1984 Sep;51(3):806-12 PMID: 6471168
Perturbation of the morphology of the trans-Golgi network following Brefeldin A treatment: redistribution of a TGN-specific integral membrane protein, TGN38.
J Cell Biol. 1992 Jan;116(1):85-94 PMID: 1730751
Protein localization and virus assembly at intracellular membranes.
Curr Top Microbiol Immunol. 1991;170:67-106 PMID: 1760931
Oligomerization, transport, and Golgi retention of Punta Toro virus glycoproteins.
J Virol. 1991 Nov;65(11):5902-9 PMID: 1920619
A Golgi retention signal in a membrane-spanning domain of coronavirus E1 protein.
J Cell Biol. 1991 Oct;115(1):19-30 PMID: 1655802
Site of addition of N-acetyl-galactosamine to the E1 glycoprotein of mouse hepatitis virus-A59.
J Cell Biol. 1988 May;106(5):1475-87 PMID: 2836431
Localization of TGN38 to the trans-Golgi network: involvement of a cytoplasmic tyrosine-containing sequence.
J Cell Biol. 1993 Mar;120(5):1123-35 PMID: 8436587
Uukuniemi virus maturation: accumulation of virus particles and viral antigens in the Golgi complex.
Mol Cell Biol. 1982 Nov;2(11):1444-58 PMID: 6891745
Morphological analysis of protein transport from the ER to Golgi membranes in digitonin-permeabilized cells: role of the P58 containing compartment.
J Cell Biol. 1992 Dec;119(5):1097-116 PMID: 1447290
Membrane assembly of the triple-spanning coronavirus M protein. Individual transmembrane domains show preferred orientation.
J Biol Chem. 1992 Oct 25;267(30):21911-8 PMID: 1400501
Intracellular transport of recombinant coronavirus spike proteins: implications for virus assembly.
J Virol. 1990 Jan;64(1):339-46 PMID: 2403441
The Hantaan virus M-segment glycoproteins G1 and G2 can be expressed independently.
J Virol. 1992 Apr;66(4):1907-14 PMID: 1548747
Processing and intracellular transport of rubella virus structural proteins in COS cells.
Virology. 1990 Sep;178(1):122-33 PMID: 2117827
Coexpression of the membrane glycoproteins G1 and G2 of Hantaan virus is required for targeting to the Golgi complex.
Virology. 1992 Jan;186(1):53-64 PMID: 1727611
Pathways of protein sorting and membrane traffic between the rough endoplasmic reticulum and the Golgi complex.
Semin Cell Biol. 1992 Oct;3(5):343-55 PMID: 1457777
Uukuniemi virus glycoproteins accumulate in and cause morphological changes of the Golgi complex in the absence of virus maturation.
J Virol. 1986 Mar;57(3):899-906 PMID: 3512854
Effect of monensin on the assembly of Uukuniemi virus in the Golgi complex.
J Virol. 1985 Sep;55(3):813-22 PMID: 4020969
Molecular biology of the Bunyaviridae.
J Gen Virol. 1990 Mar;71 ( Pt 3):501-22 PMID: 2179464
The Golgi complex: in vitro veritas?
Cell. 1992 Mar 6;68(5):829-40 PMID: 1547485
Monosaccharide sequence of protein-bound glycans of Uukuniemi virus.
J Virol. 1982 Feb;41(2):390-400 PMID: 7077748
Rubella virus maturation and production in two host cell systems.
Intervirology. 1979;11(2):97-103 PMID: 107143
Conversion of a Golgi apparatus sialyltransferase to a secretory protein by replacement of the NH2-terminal signal anchor with a signal peptide.
J Biol Chem. 1989 Oct 25;264(30):17619-22 PMID: 2808334
In vitro and in vivo expression of rubella virus glycoprotein E2: the signal peptide is contained in the C-terminal region of capsid protein.
Virology. 1989 Nov;173(1):241-50 PMID: 2683361
Lysosomal sorting mutants of coronavirus E1 protein, a Golgi membrane protein.
J Cell Sci. 1990 Feb;95 ( Pt 2):191-7 PMID: 2164517
Formation and intracellular transport of a heterodimeric viral spike protein complex.
J Cell Biol. 1991 Jan;112(2):257-66 PMID: 1988460
Post-translational glycosylation of coronavirus glycoprotein E1: inhibition by monensin.
EMBO J. 1982;1(12):1499-504 PMID: 6327272
The E2 signal sequence of rubella virus remains part of the capsid protein and confers membrane association in vitro.
J Virol. 1990 Nov;64(11):5500-9 PMID: 2214022
Translocation of rubella virus glycoprotein E1 into the endoplasmic reticulum.
J Virol. 1988 Nov;62(11):4259-64 PMID: 2845137
The E1 glycoprotein of an avian coronavirus is targeted to the cis Golgi complex.
Proc Natl Acad Sci U S A. 1990 Sep;87(18):6944-8 PMID: 2169615
Golgi complex localization of the Punta Toro virus G2 protein requires its association with the G1 protein.
Virology. 1991 Jul;183(1):351-65 PMID: 1905078
Golgi retention signals: do membranes hold the key?
Trends Cell Biol. 1991 Dec;1(6):141-4 PMID: 14731855
A specific transmembrane domain of a coronavirus E1 glycoprotein is required for its retention in the Golgi region.
J Cell Biol. 1987 Sep;105(3):1205-14 PMID: 2821010
Transient translocation of the cytoplasmic (endo) domain of a type I membrane glycoprotein into cellular membranes.
J Cell Biol. 1993 Feb;120(4):877-83 PMID: 8432728
Exit of newly synthesized membrane proteins from the trans cisterna of the Golgi complex to the plasma membrane.
J Cell Biol. 1985 Sep;101(3):949-64 PMID: 2863275
Density of newly synthesized plasma membrane proteins in intracellular membranes II. Biochemical studies.
J Cell Biol. 1984 Jun;98(6):2142-7 PMID: 6563038
Assembly of coronavirus spike protein into trimers and its role in epitope expression.
J Virol. 1990 Nov;64(11):5367-75 PMID: 2170676
Localization to the Golgi complex of Uukuniemi virus glycoproteins G1 and G2 expressed from cloned cDNAs.
J Virol. 1992 Jul;66(7):4525-31 PMID: 1602557
Cell biology of viruses that assemble along the biosynthetic pathway.
Semin Cell Biol. 1992 Oct;3(5):367-81 PMID: 1333835
O-glycosylation of the coronavirus M protein. Differential localization of sialyltransferases in N- and O-linked glycosylation.
J Biol Chem. 1992 Jul 15;267(20):14094-101 PMID: 1629209
Dissection of the Golgi complex. I. Monensin inhibits the transport of viral membrane proteins from medial to trans Golgi cisternae in baby hamster kidney cells infected with Semliki Forest virus.
J Cell Biol. 1983 Mar;96(3):835-50 PMID: 6682112
The Golgi sorting domain of coronavirus E1 protein.
J Cell Sci. 1991 Apr;98 ( Pt 4):567-75 PMID: 1860903
Assembly and polarized release of Punta Toro virus and effects of brefeldin A.
J Virol. 1991 Mar;65(3):1427-39 PMID: 1847462
Replication of coronavirus MHV-A59 in sac- cells: determination of the first site of budding of progeny virions.
Eur J Cell Biol. 1984 Mar;33(2):281-93 PMID: 6325194
The rubella virus E2 and E1 spike glycoproteins are targeted to the Golgi complex.
J Cell Biol. 1993 Apr;121(2):269-81 PMID: 8468347
The rubella virus E1 glycoprotein is arrested in a novel post-ER, pre-Golgi compartment.
J Cell Biol. 1992 Aug;118(4):795-811 PMID: 1500424
Oligomerization of the structural proteins of rubella virus.
Virology. 1991 Dec;185(2):811-9 PMID: 1962452
Rubella virus 40S genome RNA specifies a 24S subgenomic mRNA that codes for a precursor to structural proteins.
J Virol. 1984 Feb;49(2):403-8 PMID: 6694262
Rubella virus contains one capsid protein and three envelope glycoproteins, E1, E2a, and E2b.
J Virol. 1983 Jun;46(3):964-73 PMID: 6854740
Characterization of carbohydrates linked to rubella virus glycoprotein E2.
J Gen Virol. 1991 Apr;72 ( Pt 4):843-50 PMID: 2016596
Involvement of beta-COP in membrane traffic through the Golgi complex.
Trends Cell Biol. 1991 Jul;1(1):14-9 PMID: 14731804
Identification, sequencing and expression of an integral membrane protein of the trans-Golgi network (TGN38).
Biochem J. 1990 Aug 15;270(1):97-102 PMID: 2204342
Compartmentation of the Golgi complex: brefeldin-A distinguishes trans-Golgi cisternae from the trans-Golgi network.
J Cell Biol. 1990 Sep;111(3):893-9 PMID: 2167898
The trans-Golgi network can be dissected structurally and functionally from the cisternae of the Golgi complex by brefeldin A.
Eur J Cell Biol. 1992 Oct;59(1):92-105 PMID: 1468449

Article Info

Journal

Trends in microbiology

Abbr.

Trends Microbiol

ISSN

0966-842X

DOI

10.1016/0966-842x(93)90126-c

Published

1993-07-00

Pages

124-30

Language

English

Region

England

NLM ID

9310916

PMCID

PMC7133355

Subset

External Links

PubMed source DOI: 10.1016/0966-842x(93)90126-c PMC Full Text View journal details

Analysis Services

Targeting of viral glycoproteins to the Golgi complex.

Contact

WeChat Official Account