Home LiteratureArticle Details
PMID: 8246966 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Yin-yang 1 activates the c-myc promoter.

Molecular and cellular biology ·Vol. 13 ·No. 12 ·1993-12-00 ·Pages 7487-95

Riggs KJ, Saleque S, Wong KK, Merrell KT, Lee JS, Shi Y, Calame K

Abstract

Previous studies on the murine c-myc promoter demonstrated that a ubiquitously present protein, common factor 1 (CF1), bound at two sites located -260 and -390 bp from the P1 transcription start site. CF1 has been purified to near homogeneity and shown to be identical to the zinc finger protein Yin-yang 1 (YY1) as judged by similarity of molecular weight and other biochemical properties, immunological cross-reactivity, and the ability of recombinant YY1 to bind to CF1 sites. In cotransfection experiments, YY1 is a strong activator of transcription from c-myc promoter-based reporters. Furthermore, in murine erythroleukemia cells, overexpressed YY1 causes increased levels of c-myc mRNA initiated from both major transcription initiation sites of the endogenous c-myc gene.

Related Genes
c-myc
MeSH Terms
3T3 Cells Animals Base Sequence Binding Sites/genetics DNA/genetics DNA-Binding Proteins/biosynthesis,genetics,isolation & purification Erythroid-Specific DNA-Binding Factors Gene Expression Regulation Genes, myc Humans Mice Molecular Sequence Data Molecular Weight Oligonucleotide Probes Promoter Regions, Genetic RNA, Messenger/genetics,metabolism Trans-Activators/genetics Transcription Factors/biosynthesis,genetics,isolation & purification Transcription, Genetic Transcriptional Activation Transfection YY1 Transcription Factor Zinc Fingers/genetics
Chemicals
DNA-Binding Proteins Erythroid-Specific DNA-Binding Factors Oligonucleotide Probes RNA, Messenger Trans-Activators Transcription Factors YY1 Transcription Factor YY1 protein, human Yy1 protein, mouse DNA
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Riggs K J
Department of Biological Chemistry, University of California, Los Angeles 90024.
Saleque S
Wong K K
Merrell K T
Lee J S
Shi Y
Calame K
References (41)
41 references, click to expand
  1. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.
    Anal Biochem. 1976 May 7;72:248-54 PMID: 942051
  2. Activation of skeletal alpha-actin gene transcription: the cooperative formation of serum response factor-binding complexes over positive cis-acting promoter serum response elements displaces a negative-acting nuclear factor enriched in replicating myoblasts and nonmyogenic cells.
    Mol Cell Biol. 1991 Oct;11(10):5090-100 PMID: 1922033
  3. c-myc oncogene expression inhibits the initiation of myogenic differentiation.
    Exp Cell Res. 1987 Sep;172(1):212-7 PMID: 2443373
  4. A plasmacytoma-specific factor binds the c-myc promoter region.
    Proc Natl Acad Sci U S A. 1987 Oct;84(20):7031-5 PMID: 3313385
  5. In vivo functional analysis of in vitro protein binding sites in the immunoglobulin heavy chain enhancer.
    Nucleic Acids Res. 1988 Apr 25;16(8):3239-53 PMID: 3131736
  6. Mutational analysis of the contribution of sequence motifs within the IgH enhancer to tissue specific transcriptional activation.
    Nucleic Acids Res. 1988 Jul 11;16(13):6085-96 PMID: 3135535
  7. Type 1 plasminogen activator inhibitor gene: functional analysis and glucocorticoid regulation of its promoter.
    Proc Natl Acad Sci U S A. 1988 Aug;85(15):5525-9 PMID: 2840665
  8. Autocrine growth and tumorigenicity of interleukin 2-dependent helper T cells transfected with IL-2 gene.
    J Exp Med. 1989 Jan 1;169(1):13-25 PMID: 2521241
  9. Nuclear factor E2F mediates basic transcription and trans-activation by E1a of the human MYC promoter.
    Genes Dev. 1989 Apr;3(4):527-36 PMID: 2721961
  10. Trans-activation of human MYC: the second promoter is target for the stimulation by adenovirus E1a proteins.
    Oncogene. 1989 May;4(5):535-41 PMID: 2471129
  11. Concentration-dependent transcriptional activation or repression by Krüppel from a single binding site.
    Nature. 1991 Oct 10;353(6344):563-6 PMID: 1922363
  12. Delta, a transcription factor that binds to downstream elements in several polymerase II promoters, is a functionally versatile zinc finger protein.
    Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9799-803 PMID: 1946404
  13. Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site.
    Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9804-8 PMID: 1946405
  14. Transcriptional and transforming activities of the adenovirus E1A proteins.
    Adv Cancer Res. 1991;57:47-85 PMID: 1835254
  15. YY1 is an initiator sequence-binding protein that directs and activates transcription in vitro.
    Nature. 1991 Nov 21;354(6350):241-5 PMID: 1720509
  16. Coactivators for a proline-rich activator purified from the multisubunit human TFIID complex.
    Genes Dev. 1991 Dec;5(12A):2212-24 PMID: 1748279
  17. Cloning of a negative transcription factor that binds to the upstream conserved region of Moloney murine leukemia virus.
    Mol Cell Biol. 1992 Jan;12(1):38-44 PMID: 1309593
  18. Characterization of the yeast SWI1, SWI2, and SWI3 genes, which encode a global activator of transcription.
    Cell. 1992 Feb 7;68(3):573-83 PMID: 1339306
  19. myc function and regulation.
    Annu Rev Biochem. 1992;61:809-60 PMID: 1497324
  20. Functional antagonism between YY1 and the serum response factor.
    Mol Cell Biol. 1992 Sep;12(9):4209-14 PMID: 1508214
  21. Displacement of BrdUrd-induced YY1 by serum response factor activates skeletal alpha-actin transcription in embryonic myoblasts.
    Proc Natl Acad Sci U S A. 1992 Oct 15;89(20):9814-8 PMID: 1409704
  22. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.
    Mol Cell Biol. 1982 Sep;2(9):1044-51 PMID: 6960240
  23. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.
    Nucleic Acids Res. 1983 Mar 11;11(5):1475-89 PMID: 6828386
  24. Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor.
    Cell. 1983 Dec;35(3 Pt 2):603-10 PMID: 6606489
  25. Distinctive effects of the viral oncogenes myc, erb, fps, and src on the differentiation program of quail myogenic cells.
    Proc Natl Acad Sci U S A. 1985 Jan;82(2):426-30 PMID: 2982156
  26. Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family.
    Nucleic Acids Res. 1985 Mar 11;13(5):1431-42 PMID: 2987824
  27. Chromosome translocations clustered 5' of the murine c-myc gene qualitatively affect promoter usage: implications for the site of normal c-myc regulation.
    EMBO J. 1985 Jun;4(6):1441-7 PMID: 2992931
  28. E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor.
    Proc Natl Acad Sci U S A. 1989 May;86(10):3594-8 PMID: 2524830
  29. A transcriptional repressor of c-myc.
    Nature. 1989 Jun 29;339(6227):718-21 PMID: 2662014
  30. Localization of transcriptional regulatory elements and nuclear factor binding sites in mouse ribosomal protein gene rpL32.
    Mol Cell Biol. 1989 May;9(5):2067-74 PMID: 2546059
  31. Equipotent mouse ribosomal protein promoters have a similar architecture that includes internal sequence elements.
    Genes Dev. 1989 Nov;3(11):1789-800 PMID: 2606348
  32. The c-myc proto-oncogene regulates cardiac development in transgenic mice.
    Mol Cell Biol. 1990 Jul;10(7):3709-16 PMID: 1694017
  33. Selective inhibition of activated but not basal transcription by the acidic activation domain of VP16: evidence for transcriptional adaptors.
    Cell. 1990 Jun 29;61(7):1199-208 PMID: 2163758
  34. A novel mediator between activator proteins and the RNA polymerase II transcription apparatus.
    Cell. 1990 Jun 29;61(7):1209-15 PMID: 2163759
  35. Common factor 1 is a transcriptional activator which binds in the c-myc promoter, the skeletal alpha-actin promoter, and the immunoglobulin heavy-chain enhancer.
    Mol Cell Biol. 1991 Mar;11(3):1765-9 PMID: 1899910
  36. c-myc inhibition of MyoD and myogenin-initiated myogenic differentiation.
    Mol Cell Biol. 1991 May;11(5):2842-51 PMID: 1850105
  37. Adenovirus E1B 19-kilodalton protein overcomes the cytotoxicity of E1A proteins.
    J Virol. 1991 Jun;65(6):2968-78 PMID: 1851867
  38. Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activation.
    Cell. 1991 Aug 9;66(3):563-76 PMID: 1907890
  39. Subunit promiscuity among hemopoietic growth factor receptors.
    Cell. 1991 Oct 4;67(1):1-4 PMID: 1913811
  40. Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein.
    Cell. 1991 Oct 18;67(2):377-88 PMID: 1655281
  41. Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility.
    Science. 1987 Jun 19;236(4808):1573-7 PMID: 3109035
Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.13.12.7487-7495.1993
Published
1993-12-00
Pages
7487-95
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC364820
Subset
IM
Grants
NCI NIH HHS · CA 38571 · United States
NIGMS NIH HHS · GM 07367 · United States
External Links
PubMed source DOI: 10.1128/mcb.13.12.7487-7495.1993 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2