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PMID: 8302848 Published · ppublish English Comparative Study Journal Article

A human amphotropic retrovirus receptor is a second member of the gibbon ape leukemia virus receptor family.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 91 ·No. 3 ·1994-02-01 ·Pages 1168-72

van Zeijl M, Johann SV, Closs E, Cunningham J, Eddy R, Shows TB, O'Hara B

Abstract

Retrovirus infection is initiated by binding of the viral envelope glycoprotein to a cell-surface receptor. The envelope proteins of type C retroviruses of mammals demonstrate similarities in structural organization and protein sequence. These similarities suggest the possibility that retroviruses from different interference groups might use related proteins as receptors, despite the absence of any relationship between retrovirus receptors isolated to date. To investigate this possibility, we have identified a human cDNA clone encoding a protein closely related to the receptor for gibbon ape leukemia virus and have found that it functions as the receptor for the amphotropic group of murine retroviruses. Expression of this protein (GLVR-2) is likely to be a requirement for infection of human cells by amphotropic retroviral vectors for purposes of gene therapy.

Related Genes
Ram-1
MeSH Terms
3T3 Cells Amino Acid Sequence Animals CHO Cells Carrier Proteins/genetics Cell Line Chromosome Mapping Cloning, Molecular Cricetinae DNA, Complementary/genetics Gene Expression Genetic Vectors Humans Leukemia Virus, Gibbon Ape/metabolism Leukemia Virus, Murine/metabolism Membrane Glycoproteins Membrane Proteins/genetics Mice Molecular Sequence Data Receptors, Virus/genetics Retroviridae/metabolism Sequence Homology, Amino Acid Sodium-Phosphate Cotransporter Proteins, Type III
Chemicals
Carrier Proteins DNA, Complementary Membrane Glycoproteins Membrane Proteins Receptors, Virus SLC20A2 protein, human Sodium-Phosphate Cotransporter Proteins, Type III ecotropic murine leukemia virus receptor leukemia virus receptor, gibbon ape
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
van Zeijl M
Molecular Biology Research Section, American Cyanamid Company, Pearl River, NY 10965.
Johann S V
Closs E
Cunningham J
Eddy R
Shows T B
O'Hara B
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.91.3.1168
Published
1994-02-01
Pages
1168-72
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC521475
Subset
IM
Databases
GENBANK
L20852
External Links
PubMed source DOI: 10.1073/pnas.91.3.1168 PMC Full Text View journal details
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