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PMID: 8506143 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Ancestry and diversity of the HMG box superfamily.

Nucleic acids research ·Vol. 21 ·No. 10 ·1993-05-25 ·Pages 2493-501

Laudet V, Stehelin D, Clevers H

Abstract

The HMG box is a novel type of DNA-binding domain found in a diverse group of proteins. The HMG box superfamily comprises a.o. the High Mobility Group proteins HMG1 and HMG2, the nucleolar transcription factor UBF, the lymphoid transcription factors TCF-1 and LEF-1, the fungal mating-type genes mat-Mc and MATA1, and the mammalian sex-determining gene SRY. The superfamily dates back to at least 1,000 million years ago, as its members appear in animals, plants and yeast. Alignment of all known HMG boxes defined an unusually loose consensus sequence. We constructed phylogenetic trees connecting the members of the HMG box superfamily in order to understand their evolution. This analysis led us to distinguish two subfamilies: one comprising proteins with a single sequence-specific HMG box, the other encompassing relatively non sequence-specific DNA-binding proteins with multiple HMG boxes. By studying the extent of diversification of the superfamily, we found that the speed of evolution was very different within the various groups of HMG-box containing factors. Comparison of the evolution of the two boxes of ABF2 and of mtTF1 implied different diversification models for these two proteins. Finally, we provide a tree for the highly complex group of SRY-like ('Sox' genes), clustering at least 40 different loci that rapidly diverged in various animal lineages.

MeSH Terms
Amino Acid Sequence Animals Binding Sites Biological Evolution Consensus Sequence DNA/metabolism DNA-Binding Proteins/chemistry,genetics,metabolism High Mobility Group Proteins/chemistry,metabolism Humans Molecular Sequence Data Phylogeny Sequence Homology, Amino Acid
Chemicals
DNA-Binding Proteins High Mobility Group Proteins DNA
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Laudet V
CNRS URA 1160, Institut Pasteur, Lille, France.
Stehelin D
Clevers H
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56 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/21.10.2493
Published
1993-05-25
Pages
2493-501
Language
English
Region
England
NLM ID
0411011
PMCID
PMC309552
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/21.10.2493 PMC Full Text View journal details
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