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PMID: 8668199 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

MEF2B is a potent transactivator expressed in early myogenic lineages.

Molecular and cellular biology ·Vol. 16 ·No. 7 ·1996-07-00 ·Pages 3814-24

Molkentin JD, Firulli AB, Black BL, Martin JF, Hustad CM, Copeland N, Jenkins N, Lyons G, Olson EN

Abstract

There are four members of the myocyte enhancer binding factor 2 (MEF2) family of transcription factors, MEF2A, -B, -C, and -D, that have homology within an amino-terminal MADS box and an adjacent MEF2 domain that together mediate dimerization and DNA binding. MEF2A, -C, and -D have previously been shown to bind an A/T-rich DNA sequence in the control regions of numerous muscle-specific genes, whereas MEF2B was reported to be unable to bind this sequence unless the carboxyl terminus was deleted. To further define the functions of MEF2B, we analyzed its DNA binding and transcriptional activities. In contrast to previous studies, our results show that MEF2B binds the same DNA sequence as other members of the MEF2 family and acts as a strong transactivator through that sequence. Transcriptional activation by MEF2B is dependent on the carboxyl terminus, which contains two conserved sequence motifs found in all vertebrate MEF2 factors. During mouse embryogenesis, MEF2B transcripts are expressed in the developing cardiac and skeletal muscle lineages in a temporospatial pattern distinct from but overlapping with those of the other Mef2 genes. The mouse Mef2b gene maps to chromosome 8 and is unlinked to other Mef2 genes; its intron-exon organization is similar to that of the other vertebrate Mef2 genes and the single Drosophila Mef2 gene, consistent with the notion that these different Mef2 genes evolved from a common ancestral gene.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Cell Line Consensus Sequence Crosses, Genetic DNA-Binding Proteins/biosynthesis,chemistry,metabolism Embryo, Mammalian Enhancer Elements, Genetic Female Gene Expression Regulation, Developmental Genomic Library Heart/embryology MEF2 Transcription Factors Male Mice Mice, Inbred C57BL Molecular Sequence Data Muridae Muscle, Skeletal/embryology,metabolism Mutagenesis, Site-Directed Myocardium/metabolism Myogenic Regulatory Factors Open Reading Frames Promoter Regions, Genetic Recombinant Proteins/biosynthesis,metabolism Sequence Homology, Amino Acid Trans-Activators/biosynthesis Transcription Factors/biosynthesis,chemistry,metabolism Transcription, Genetic Transfection
Chemicals
DNA-Binding Proteins MEF2 Transcription Factors Mef2a protein, mouse Mef2b protein, mouse Myogenic Regulatory Factors Recombinant Proteins Trans-Activators Transcription Factors
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Molkentin J D
Hamon Center for Basic Cancer Research, The University of Texas Southwestern Medical Center at Dallas, 75235-9148, YSA.
Firulli A B
Black B L
Martin J F
Hustad C M
Copeland N
Jenkins N
Lyons G
Olson E N
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43 references, click to expand
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
Published
1996-07-00
Pages
3814-24
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC231378
Subset
IM
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