Home LiteratureArticle Details
PMID: 8691154 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Tyrosine phosphorylation of a human killer inhibitory receptor recruits protein tyrosine phosphatase 1C.

The Journal of experimental medicine ·Vol. 184 ·No. 1 ·1996-07-01 ·Pages 93-100

Campbell KS, Dessing M, Lopez-Botet M, Cella M, Colonna M

Abstract

Natural killer (NK) cells express killer inhibitory receptors that mediate negative regulation of NK cell cytotoxicity upon binding to MHC class I molecules on target cells. Unrelated inhibitory receptors on B cells have recently been shown to function through recruitment of phosphotyrosine phosphatase 1C (PTP-1C). Here, we show that a human killer inhibitory receptor specific for HLA-C also recruits PTP-1C after phosphorylation induced either by the pharmacological agent phenylarsine oxide or by conjugation with target cells. This recruitment is mediated by the binding of specific cytoplasmic phosphotyrosine-containing sequences to PTP-1C. These results implicate PTP-1C as a cytosolic component of the negative signaling pathway through NK cell inhibitory receptors.

MeSH Terms
Amino Acid Sequence Calcium/physiology Clone Cells Cytotoxicity, Immunologic Enzyme Activation HLA-C Antigens/metabolism Humans Intracellular Signaling Peptides and Proteins Killer Cells, Natural/physiology Molecular Sequence Data Peptides/chemistry Phosphorylation Phosphotyrosine/metabolism Protein Tyrosine Phosphatase, Non-Receptor Type 11 Protein Tyrosine Phosphatase, Non-Receptor Type 6 Protein Tyrosine Phosphatases/metabolism Receptors, Immunologic/metabolism Signal Transduction
Chemicals
HLA-C Antigens Intracellular Signaling Peptides and Proteins Peptides Receptors, Immunologic Phosphotyrosine PTPN11 protein, human PTPN6 protein, human Protein Tyrosine Phosphatase, Non-Receptor Type 11 Protein Tyrosine Phosphatase, Non-Receptor Type 6 Protein Tyrosine Phosphatases Calcium
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Campbell K S
Basel Institute for Immunology, Switzerland.
Dessing M
Lopez-Botet M
Cella M
Colonna M
References (33)
33 references, click to expand
  1. Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton.
    J Exp Med. 1995 Feb 1;181(2):577-84 PMID: 7836913
  2. Induction of hyperphosphorylation and activation of the p56lck protein tyrosine kinase by phenylarsine oxide, a phosphotyrosine phosphatase inhibitor.
    Mol Immunol. 1994 Dec;31(17):1295-302 PMID: 7997241
  3. Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells.
    Science. 1995 Apr 21;268(5209):405-8 PMID: 7716543
  4. Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains.
    Immunity. 1995 May;2(5):439-49 PMID: 7749980
  5. Of ITAMs and ITIMs: turning on and off the B cell antigen receptor.
    J Exp Med. 1995 Jun 1;181(6):1953-6 PMID: 7539033
  6. Inhibition of selective signaling events in natural killer cells recognizing major histocompatibility complex class I.
    Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6484-8 PMID: 7604018
  7. A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP.
    Science. 1995 Jul 14;269(5221):242-4 PMID: 7618087
  8. Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes.
    J Immunol. 1995 Sep 1;155(5):2306-10 PMID: 7650366
  9. Existence of both inhibitory (p58) and activatory (p50) receptors for HLA-C molecules in human natural killer cells.
    J Exp Med. 1995 Sep 1;182(3):875-84 PMID: 7650491
  10. Natural killer cells. Right-side-up and up-side-down NK-cell receptors.
    Curr Biol. 1995 Sep 1;5(9):982-5 PMID: 8542289
  11. Manipulation of B cell antigen receptor tyrosine phosphorylation using aluminum fluoride and sodium orthovanadate.
    Mol Immunol. 1995 Nov;32(16):1283-94 PMID: 8559152
  12. Recruitment of tyrosine phosphatase HCP by the killer cell inhibitor receptor.
    Immunity. 1996 Jan;4(1):77-85 PMID: 8574854
  13. A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases.
    Nature. 1991 Aug 22;352(6337):736-9 PMID: 1652101
  14. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
    Nature. 1970 Aug 15;227(5259):680-5 PMID: 5432063
  15. Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class.
    Proc Natl Acad Sci U S A. 1988 May;85(10):3435-9 PMID: 2835772
  16. Production of human cells expressing individual transferred HLA-A,-B,-C genes using an HLA-A,-B,-C null human cell line.
    J Immunol. 1989 May 1;142(9):3320-8 PMID: 2785140
  17. Isolation and expression of a cDNA clone encoding HLA-Cw6: unique characteristics of HLA-C encoded gene products.
    Immunogenetics. 1989;29(5):323-30 PMID: 2714853
  18. A family of receptor-linked protein tyrosine phosphatases in humans and Drosophila.
    Proc Natl Acad Sci U S A. 1989 Nov;86(22):8698-702 PMID: 2554325
  19. A simple method for the radioactive iodination of CD4 molecules.
    J Immunol Methods. 1990 May 8;129(1):105-9 PMID: 2338494
  20. Tyrosine phosphorylation in T cells is regulated by phosphatase activity: studies with phenylarsine oxide.
    Proc Natl Acad Sci U S A. 1990 Dec;87(23):9255-9 PMID: 1701256
  21. Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.
    Mol Cell Biol. 1992 Feb;12(2):836-46 PMID: 1732748
  22. Isolation of a src homology 2-containing tyrosine phosphatase.
    Proc Natl Acad Sci U S A. 1992 Feb 1;89(3):1123-7 PMID: 1736296
  23. Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences.
    Mol Cell Biol. 1992 May;12(5):2396-405 PMID: 1373816
  24. Cytoplasmic domain heterogeneity and functions of IgG Fc receptors in B lymphocytes.
    Science. 1992 Jun 26;256(5065):1808-12 PMID: 1535455
  25. Recognition structures on natural killer cells.
    Curr Opin Immunol. 1993 Feb;5(1):67-73 PMID: 8452676
  26. CD22 associates with the human surface IgM-B-cell antigen receptor complex.
    Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3236-40 PMID: 8475064
  27. P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities.
    J Exp Med. 1993 Aug 1;178(2):597-604 PMID: 8340759
  28. HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells.
    Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):12000-4 PMID: 8265660
  29. A 13-amino-acid motif in the cytoplasmic domain of Fc gamma RIIB modulates B-cell receptor signalling.
    Nature. 1994 Mar 3;368(6466):70-3 PMID: 8107887
  30. Tyrosine kinase-dependent activation of human NK cell functions upon stimulation through a 58-kDa surface antigen selectively expressed on discrete subsets of NK cells and T lymphocytes.
    J Immunol. 1994 Feb 15;152(4):1662-73 PMID: 8120376
  31. NKB1: a natural killer cell receptor involved in the recognition of polymorphic HLA-B molecules.
    J Exp Med. 1994 Aug 1;180(2):537-43 PMID: 8046332
  32. NK3-specific natural killer cells are selectively inhibited by Bw4-positive HLA alleles with isoleucine 80.
    J Exp Med. 1994 Oct 1;180(4):1235-42 PMID: 7931060
  33. Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1.
    Science. 1995 Apr 14;268(5208):293-7 PMID: 7716523
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.184.1.93
Published
1996-07-01
Pages
93-100
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2192677
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.184.1.93 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2