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PMID: 9162005 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C.

Science (New York, N.Y.) ·Vol. 276 ·No. 5317 ·1997-05-30 ·Pages 1404-7

Lin Q, Schwarz J, Bucana C, Olson EN

Abstract

Members of the myocyte enhancer factor-2 (MEF2) family of MADS (MCM1, agamous, deficiens, serum response factor)-box transcription factors bind an A-T-rich DNA sequence associated with muscle-specific genes. The murine MEF2C gene is expressed in heart precursor cells before formation of the linear heart tube. In mice homozygous for a null mutation of MEF2C, the heart tube did not undergo looping morphogenesis, the future right ventricle did not form, and a subset of cardiac muscle genes was not expressed. The absence of the right ventricular region of the mutant heart correlated with down-regulation of the dHAND gene, which encodes a basic helix-loop-helix transcription factor required for cardiac morphogenesis. Thus, MEF2C is an essential regulator of cardiac myogenesis and right ventricular development.

MeSH Terms
Acyltransferases/metabolism Animals Gene Expression Regulation, Developmental Gene Targeting Heart/embryology Heart Ventricles/cytology,embryology In Situ Hybridization MEF2 Transcription Factors Mice Mice, Inbred C57BL Morphogenesis/genetics,physiology Mutagenesis Myocardium/cytology Myogenic Regulatory Factors/genetics,physiology Stem Cells
Chemicals
MEF2 Transcription Factors Mef2c protein, mouse Myogenic Regulatory Factors Acyltransferases trehalose mycolyltransferase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Lin Q
Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235-9148, USA.
Schwarz J
Bucana C
Olson E N
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Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.276.5317.1404
Published
1997-05-30
Pages
1404-7
Language
English
Region
United States
NLM ID
0404511
PMCID
PMC4437729
Subset
IM
Grants
NHLBI NIH HHS · R01 HL053351 · United States
External Links
PubMed source DOI: 10.1126/science.276.5317.1404 PMC Full Text View journal details
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